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Stxbp5l Gene Detail
Summary
  • Symbol
    Stxbp5l
  • Name
    syntaxin binding protein 5-like
  • Synonyms
    A830015P08Rik, insulin level locus 1, LLGL4, T2dm1, t2md1, tomosyn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443815
    NCBI Gene: 207227
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:37114942-37384962 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    949 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443815
protein coding gene Chr16:37107075-37384984 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022799
protein coding gene Chr16:35544330-35846480 (-)
A/J MGP_AJ_G0022764
protein coding gene Chr16:33793939-34059944 (-)
AKR/J MGP_AKRJ_G0022736
protein coding gene Chr16:35079634-35354263 (-)
BALB/cJ MGP_BALBcJ_G0022765
protein coding gene Chr16:33891794-34178575 (-)
C3H/HeJ MGP_C3HHeJ_G0022529
protein coding gene Chr16:35203915-35481677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023212
protein coding gene Chr16:36384951-36686265 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020726
protein coding gene Chr16:34152135-34450306 (-)
CAST/EiJ MGP_CASTEiJ_G0022055
protein coding gene Chr16:35326330-35617242 (-)
CBA/J MGP_CBAJ_G0022500
protein coding gene Chr16:37970974-38280590 (-)
DBA/2J MGP_DBA2J_G0022632
protein coding gene Chr16:33689048-33957106 (-)
FVB/NJ MGP_FVBNJ_G0022607
protein coding gene Chr16:33722095-33984898 (-)
LP/J MGP_LPJ_G0022700
protein coding gene Chr16:35255853-35541369 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022626
protein coding gene Chr16:37035724-37413804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023227
protein coding gene Chr16:35036516-35324937 (-)
PWK/PhJ MGP_PWKPhJ_G0021795
protein coding gene Chr16:34085669-34348073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021626
protein coding gene Chr16:34952327-35235283 (-)
WSB/EiJ MGP_WSBEiJ_G0022099
protein coding gene Chr16:35094799-35397470 (-)



Homology
more
  • Human Ortholog
    STXBP5L, syntaxin binding protein 5 like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STXBP5L, syntaxin binding protein 5 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LLGL4
  • Links
    NCBI Gene ID: 9515
    neXtProt AC: NX_Q9Y2K9
    UniProt: Q9Y2K9

  • Chr Location
    3q13.33; chr3:120908203-121424761 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit background sensitive embryonic/postnatal lethality, altered motor performance and impaired NMJ neurotransmission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022829 Ensembl Gene Model | MGI Sequence Detail 270021 C57BL/6J ±  kb
    transcript ENSMUST00000114787 Ensembl | MGI Sequence Detail 4394 Not Applicable  
    polypeptide ENSMUSP00000110435 Ensembl | MGI Sequence Detail 1185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2152040
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65486 Stoehr JP, et al., Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes. 2000 Nov;49(11):1946-54
    • Latest
      J:245234 Geerts CJ, et al., Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains. PLoS One. 2017;12(7):e0180912

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory