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Osbpl8 Gene Detail
Summary
  • Symbol
    Osbpl8
  • Name
    oxysterol binding protein-like 8
  • Synonyms
    D330025H14Rik, ORP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443807
    NCBI Gene: 237542
  • Gene Overview
    MyGene.info: OSBPL8
Location & Maps
more
  • Sequence Map
    Chr10:111164802-111297247 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      132446 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 58.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OSBPL8, oxysterol binding protein like 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OSBPL8, oxysterol binding protein like 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MST120, MSTP120, ORP8, OSBP10
  • Links
    NCBI Gene ID: 114882
    neXtProt AC: NX_Q9BZF1

  • Chr Location
    12q14; chr12:76351797-76559809 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    2
  • Genomic Mutations
    1 involving Osbpl8
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit elevated of HDL and gender-specific alterations in lipid metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020189 Ensembl Gene Model | MGI Sequence Detail 132446 C57BL/6J ±  kb
transcript ENSMUST00000105275 Ensembl | MGI Sequence Detail 7152 Not Applicable  
polypeptide ENSMUSP00000100911 Ensembl | MGI Sequence Detail 889 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1705 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012053 oxysterol-binding protein-related protein 8
  • InterPro Domains
    IPR000648 Oxysterol-binding protein
    IPR018494 Oxysterol-binding protein, conserved site
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2143486, MGI:2143487, MGI:2443126
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:78568 Anniss AM, et al., An oxysterol-binding protein family identified in the mouse. DNA Cell Biol. 2002 Aug;21(8):571-80
  • Latest
    J:223099 van Kampen E, et al., Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice. PLoS One. 2014;9(10):e109024

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory