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Bnc2 Gene Detail
Summary
  • Symbol
    Bnc2
  • Name
    basonuclin 2
  • Synonyms
    5031434M05Rik, 8430420F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443805
    NCBI Gene: 242509
  • Gene Overview
    MyGene.info: BNC2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:84275095-84675275 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      400181 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 39.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    BNC2, basonuclin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BNC2, basonuclin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BSN2
  • Links
    NCBI Gene ID: 54796
    neXtProt AC: NX_Q6ZN30
    UniProt: Q6ZN30

  • Chr Location
    9p22.3-p22.2; chr9:16409503-16870838 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18243
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BNC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion die within 24 hrs of birth and display cleft palate, an overall size reduction of the head and tongue, and abnormal craniofacial bone development due to impaired multiplication of embryonic craniofacial mesenchymal cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006757 VEGA Gene Model | MGI Sequence Detail 400181 C57BL/6J ±  kb
    transcript OTTMUST00000015531 VEGA | MGI Sequence Detail 4133 Not Applicable  
    polypeptide OTTMUSP00000007156 VEGA | MGI Sequence Detail 1127 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3030 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 17
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918748
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:231834 Vanhoutteghem A, et al., The importance of basonuclin 2 in adult mice and its relation to basonuclin 1. Mech Dev. 2016 May;140:53-73

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory