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Engase Gene Detail
Summary
  • Symbol
    Engase
  • Name
    endo-beta-N-acetylglucosaminidase
  • Synonyms
    D230014K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443788
    NCBI Gene: 217364
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118476829-118489209 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443788
protein coding gene Chr11:118476066-118489209 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019469
protein coding gene Chr11:122801746-122814236 (+)
A/J MGP_AJ_G0019437
protein coding gene Chr11:117364083-117376557 (+)
AKR/J MGP_AKRJ_G0019407
protein coding gene Chr11:120922790-120935013 (+)
BALB/cJ MGP_BALBcJ_G0019412
protein coding gene Chr11:117725893-117738071 (+)
C3H/HeJ MGP_C3HHeJ_G0019218
protein coding gene Chr11:121229776-121242962 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019861
protein coding gene Chr11:126564729-126577004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017486
protein coding gene Chr11:114362791-114374919 (+)
CAST/EiJ MGP_CASTEiJ_G0018772
protein coding gene Chr11:122657155-122669289 (+)
CBA/J MGP_CBAJ_G0019189
protein coding gene Chr11:131476435-131491154 (+)
DBA/2J MGP_DBA2J_G0019301
protein coding gene Chr11:116744929-116757173 (+)
FVB/NJ MGP_FVBNJ_G0019293
protein coding gene Chr11:116393140-116406098 (+)
LP/J MGP_LPJ_G0019371
protein coding gene Chr11:123123717-123136981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019326
protein coding gene Chr11:130471422-130483767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019900
protein coding gene Chr11:121585939-121598322 (+)
PWK/PhJ MGP_PWKPhJ_G0018538
protein coding gene Chr11:118133521-118145748 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018330
protein coding gene Chr11:121305684-121317877 (+)
WSB/EiJ MGP_WSBEiJ_G0018824
protein coding gene Chr11:121540932-121554197 (+)



Homology
more
  • Human Ortholog
    ENGASE, endo-beta-N-acetylglucosaminidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ENGASE, endo-beta-N-acetylglucosaminidase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64772
    neXtProt AC: NX_Q8NFI3
    UniProt: Q8NFI3

  • Chr Location
    17q25.3; chr17:79074812-79088603 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozgyous for knock-out alleles of this gene and Ngly1 exhibit restored endoplasmic reticulum (ER)-associated degradation (ERAD) process compared with MEFs lacking only Ngly1.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033857 Ensembl Gene Model | MGI Sequence Detail 12381 C57BL/6J ±  kb
transcript ENSMUST00000135383 Ensembl | MGI Sequence Detail 4064 Not Applicable  
polypeptide ENSMUSP00000117538 Ensembl | MGI Sequence Detail 734 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 33
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:258809 Fujihira H, et al., Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. PLoS Genet. 2017 Apr;13(4):e1006696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory