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Engase Gene Detail
Summary
  • Symbol
    Engase
  • Name
    endo-beta-N-acetylglucosaminidase
  • Synonyms
    D230014K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443788
    NCBI Gene: 217364
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118367655-118380035 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443788
 protein coding gene Chr11:118367635-118380038 (+)
129S1/SvImJ ENSMUSG00200047368
 protein coding gene Chr11:115734280-115746737 (+)
A/J ENSMUSG00195028737
 protein coding gene Chr11:115409113-115421570 (+)
AKR/J ENSMUSG00220027616
 protein coding gene Chr11:115559580-115572037 (+)
BALB/cJ ENSMUSG00180048950
 protein coding gene Chr11:115696194-115708574 (+)
C3H/HeJ ENSMUSG00175033393
 protein coding gene Chr11:115660701-115673158 (+)
C57BL/6NJ ENSMUSG00215045638
 protein coding gene Chr11:115230093-115242473 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017486
 protein coding gene Chr11:114362791-114374919 (+)
CAST/EiJ ENSTCUG00005032607
 protein coding gene Chr11:115086173-115098460 (+)
CBA/J ENSMUSG00210047330
 protein coding gene Chr11:115374831-115387288 (+)
DBA/2J ENSMUSG00185021653
 protein coding gene Chr11:115687912-115700369 (+)
FVB/NJ ENSMUSG00205024532
 protein coding gene Chr11:115536678-115549134 (+)
JF1/MsJ ENSUMUG00000042751
 protein coding gene Chr11:115979138-115991410 (+)
LP/J ENSMUSG00230049941
 protein coding gene Chr11:116753826-116766283 (+)
NOD/ShiLtJ ENSMUSG00190030652
 protein coding gene Chr11:115758285-115770742 (+)
NZO/HlLtJ ENSMUSG00225052956
 protein coding gene Chr11:118901915-118914372 (+)
PWK/PhJ ENSLUMG00010019678
 protein coding gene Chr11:115492061-115504336 (+)
SPRET/EiJ ENSMSPG00010040455
 protein coding gene Chr11:116060538-116072803 (+)
WSB/EiJ ENSIUOG00005039496
 protein coding gene Chr11:115494767-115507225 (+)



Homology
more
  • Human Ortholog
    ENGASE, endo-beta-N-acetylglucosaminidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENGASE, endo-beta-N-acetylglucosaminidase
  • Links
    NCBI Gene ID: 64772
    UniProt: Q8NFI3

  • Chr Location
    17q25.3; chr17:79074824-79088599 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    12 phenotype references
Mice homozgyous for knock-out alleles of this gene and Ngly1 exhibit restored endoplasmic reticulum (ER)-associated degradation (ERAD) process compared with MEFs lacking only Ngly1.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    33
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033857 Ensembl Gene Model | MGI Sequence Detail 12381 C57BL/6J ±  kb
transcript ENSMUST00000135383 Ensembl | MGI Sequence Detail 4064 Not Applicable  
polypeptide ENSMUSP00000117538 Ensembl | MGI Sequence Detail 734 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 33
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory