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Large2 Gene Detail
Summary
  • Symbol
    Large2
  • Name
    LARGE xylosyl- and glucuronyltransferase 2
  • Synonyms
    5730485C17Rik, Gyltl1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443769
    NCBI Gene: 228366
  • Gene Overview
    MyGene.info: LARGE2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92365046-92371755 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443769
protein coding gene Chr2:92365046-92374869 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026164
protein coding gene Chr2:93795710-93805533 (-)
A/J MGP_AJ_G0026125
protein coding gene Chr2:89998676-90008497 (-)
AKR/J MGP_AKRJ_G0026106
protein coding gene Chr2:92486187-92497777 (-)
BALB/cJ MGP_BALBcJ_G0026134
protein coding gene Chr2:90183048-90192868 (-)
C3H/HeJ MGP_C3HHeJ_G0025885
protein coding gene Chr2:92793523-92803715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026585
protein coding gene Chr2:97010608-97020815 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023976
protein coding gene Chr2:86490217-86500815 (-)
CAST/EiJ MGP_CASTEiJ_G0025350
protein coding gene Chr2:93340045-93349883 (-)
CBA/J MGP_CBAJ_G0025863
protein coding gene Chr2:100396975-100406798 (-)
DBA/2J MGP_DBA2J_G0025999
protein coding gene Chr2:89591738-89601560 (-)
FVB/NJ MGP_FVBNJ_G0025962
protein coding gene Chr2:88702000-88712368 (-)
LP/J MGP_LPJ_G0026103
protein coding gene Chr2:93991775-94001596 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025988
protein coding gene Chr2:103355424-103365247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026639
protein coding gene Chr2:92571509-92581331 (-)
PWK/PhJ MGP_PWKPhJ_G0025085
protein coding gene Chr2:89337280-89347183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024886
protein coding gene Chr2:92140971-92151516 (-)
WSB/EiJ MGP_WSBEiJ_G0025417
protein coding gene Chr2:93189557-93199378 (-)



Homology
more
  • Human Ortholog
    LARGE2, LARGE xylosyl- and glucuronyltransferase 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LARGE2, LARGE xylosyl- and glucuronyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GYLTL1B, PP5656
  • Links
    NCBI Gene ID: 120071
    neXtProt AC: NX_Q8N3Y3
    UniProt: Q8N3Y3

  • Chr Location
    11p11.2; chr11:45921621-45929096 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Null mutant mice are healthy and are indistinguishable from control littermates with respect to body weight and life span when aged up to one year. No increased spontaneous tumor load was observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228366 NCBI Gene Model | MGI Sequence Detail 6710 C57BL/6J ±  kb
transcript NM_001290775 RefSeq | MGI Sequence Detail 2673 C57BL/6  
polypeptide Q5XPT3 UniProt | EBI | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 1
    cDNA 42
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2139110
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory