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Mat2a Gene Detail
Summary
  • Symbol
    Mat2a
  • Name
    methionine adenosyltransferase 2A
  • Synonyms
    D630045P18Rik, MGC:6545
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443731
    NCBI Gene: 232087
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72409782-72416541 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443731
protein coding gene Chr6:72409779-72416541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030877
protein coding gene Chr6:72984417-72992921 (-)
A/J MGP_AJ_G0030847
protein coding gene Chr6:70155381-70162140 (-)
AKR/J MGP_AKRJ_G0030776
protein coding gene Chr6:72222631-72230006 (-)
BALB/cJ MGP_BALBcJ_G0030858
protein coding gene Chr6:70182848-70190192 (-)
C3H/HeJ MGP_C3HHeJ_G0030854
protein coding gene Chr6:112013047-112020679 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031316
protein coding gene Chr6:74900063-74908772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028505
protein coding gene Chr6:69302346-69308733 (-)
CAST/EiJ MGP_CASTEiJ_G0029966
protein coding gene Chr6:72086095-72093050 (-)
CBA/J MGP_CBAJ_G0030545
protein coding gene Chr6:77950560-77957113 (-)
DBA/2J MGP_DBA2J_G0030697
protein coding gene Chr6:69549929-69556436 (-)
FVB/NJ MGP_FVBNJ_G0030650
protein coding gene Chr6:68940667-68947426 (-)
LP/J MGP_LPJ_G0030776
protein coding gene Chr6:72893284-72901560 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030685
protein coding gene Chr6:81346968-81355416 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031342
protein coding gene Chr6:72033719-72040582 (-)
PWK/PhJ MGP_PWKPhJ_G0029682
protein coding gene Chr6:68461909-68467482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029510
protein coding gene Chr6:70759254-70768623 (-)
WSB/EiJ MGP_WSBEiJ_G0030048
protein coding gene Chr6:72397982-72414843 (-)



Homology
more
  • Human Ortholog
    MAT2A, methionine adenosyltransferase 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAT2A, methionine adenosyltransferase 2A
  • Synonyms
    MATA2, MATII, SAMS2
  • Links
    NCBI Gene ID: 4144
    neXtProt AC: NX_P31153
    UniProt: P31153

  • Chr Location
    2p11.2; chr2:85539168-85545281 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human MAT2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053907 Ensembl Gene Model | MGI Sequence Detail 6760 C57BL/6J ±  kb
transcript ENSMUST00000059472 Ensembl | MGI Sequence Detail 2804 Not Applicable  
polypeptide ENSMUSP00000087118 Ensembl | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000010202 S-adenosylmethionine synthetase isoform type-2
  • EC
  • InterPro Domains
    IPR002133 S-adenosylmethionine synthetase
    IPR022629 S-adenosylmethionine synthetase, central domain
    IPR022631 S-adenosylmethionine synthetase, conserved site
    IPR022630 S-adenosylmethionine synthetase, C-terminal
    IPR022628 S-adenosylmethionine synthetase, N-terminal
    IPR022636 S-adenosylmethionine synthetase superfamily
Molecular
Reagents
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  • All nucleic 23
    cDNA 19
    Primer pair 4

    Microarray probesets 7
References
more
  • Summaries
    All 53
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:342248 Li ML, et al., S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency. Development. 2023 Oct 15;150(20):dev201135

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory