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Ythdc1 Gene Detail
Summary
  • Symbol
    Ythdc1
  • Name
    YTH domain containing 1
  • Synonyms
    A730098D12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443713
    NCBI Gene: 231386
  • Gene Overview
    MyGene.info: YTHDC1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:86804221-86836659 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443713
protein coding gene Chr5:86803980-86836659 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029674
protein coding gene Chr5:87655457-87690687 (+)
A/J MGP_AJ_G0029642
protein coding gene Chr5:84069412-84103352 (+)
AKR/J MGP_AKRJ_G0029590
protein coding gene Chr5:86860409-86893537 (+)
BALB/cJ MGP_BALBcJ_G0029651
protein coding gene Chr5:84985335-85017627 (+)
C3H/HeJ MGP_C3HHeJ_G0029374
protein coding gene Chr5:87325989-87361196 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030105
protein coding gene Chr5:91259769-91310926 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027347
protein coding gene Chr5:79875173-79908538 (+)
CAST/EiJ MGP_CASTEiJ_G0028782
protein coding gene Chr5:86621764-86655138 (+)
CBA/J MGP_CBAJ_G0029343
protein coding gene Chr5:94194067-94233734 (+)
DBA/2J MGP_DBA2J_G0029488
protein coding gene Chr5:84262449-84295669 (+)
FVB/NJ MGP_FVBNJ_G0029449
protein coding gene Chr5:83184778-83220045 (+)
LP/J MGP_LPJ_G0029575
protein coding gene Chr5:88076396-88125866 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029477
protein coding gene Chr5:99081732-99114892 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030138
protein coding gene Chr5:86426557-86461071 (+)
PWK/PhJ MGP_PWKPhJ_G0028506
protein coding gene Chr5:83221236-83256087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028339
protein coding gene Chr5:85786868-85822654 (+)
WSB/EiJ MGP_WSBEiJ_G0028863
protein coding gene Chr5:86809040-86842716 (+)



Homology
more
  • Human Ortholog
    YTHDC1, YTH domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    YTHDC1, YTH domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    YT521, YT521-B
  • Links
    NCBI Gene ID: 91746
    neXtProt AC: NX_Q96MU7
    UniProt: Q96MU7

  • Chr Location
    4q13.2; chr4:68310387-68350106 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die between E8.5 and E11.5. Mice homozygous for a cconditional allele activated after embryonic development exhibit infertility with defects in spermatogenesis and oogenesis associated with RNA granules and altered transcription in oocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035851 Ensembl Gene Model | MGI Sequence Detail 32439 C57BL/6J ±  kb
transcript ENSMUST00000038384 Ensembl | MGI Sequence Detail 2960 Not Applicable  
polypeptide ENSMUSP00000039133 Ensembl | MGI Sequence Detail 736 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory