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Emc1 Gene Detail
Summary
  • Symbol
    Emc1
  • Name
    ER membrane protein complex subunit 1
  • Synonyms
    C230096C10Rik, mKIAA0090
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443696
    NCBI Gene: 230866
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:139352587-139378730 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443696
protein coding gene Chr4:139352587-139378735 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029017
protein coding gene Chr4:142184767-142211051 (+)
A/J MGP_AJ_G0028976
protein coding gene Chr4:136071319-136097014 (+)
AKR/J MGP_AKRJ_G0028928
protein coding gene Chr4:139970017-139997109 (+)
BALB/cJ MGP_BALBcJ_G0029000
protein coding gene Chr4:136743215-136773201 (+)
C3H/HeJ MGP_C3HHeJ_G0028714
protein coding gene Chr4:140348416-140376817 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029441
protein coding gene Chr4:147216183-147247005 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026712
protein coding gene Chr4:129026139-129052035 (+)
CAST/EiJ MGP_CASTEiJ_G0028146
protein coding gene Chr4:138533168-138559115 (+)
CBA/J MGP_CBAJ_G0028678
protein coding gene Chr4:151470084-151499524 (+)
DBA/2J MGP_DBA2J_G0028828
protein coding gene Chr4:136465617-136493464 (+)
FVB/NJ MGP_FVBNJ_G0028795
protein coding gene Chr4:135493401-135520038 (+)
LP/J MGP_LPJ_G0028927
protein coding gene Chr4:142258513-142285469 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028821
protein coding gene Chr4:155372825-155399534 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029479
protein coding gene Chr4:140498835-140526065 (+)
PWK/PhJ MGP_PWKPhJ_G0027867
protein coding gene Chr4:133315370-133341859 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027692
protein coding gene Chr4:136275557-136302968 (+)
WSB/EiJ MGP_WSBEiJ_G0028224
protein coding gene Chr4:140751558-140782049 (+)



Homology
more
  • Human Ortholog
    EMC1, ER membrane protein complex subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMC1, ER membrane protein complex subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAVIPMR, KIAA0090
  • Links
    NCBI Gene ID: 23065
    neXtProt AC: NX_Q8N766
    UniProt: Q8N766

  • Chr Location
    1p36.13; chr1:19215664-19251559 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9002
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EMC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078517 Ensembl Gene Model | MGI Sequence Detail 26144 C57BL/6J ±  kb
transcript ENSMUST00000179784 Ensembl | MGI Sequence Detail 6232 Not Applicable  
polypeptide ENSMUSP00000137103 Ensembl | MGI Sequence Detail 997 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030474 ER membrane protein complex subunit 1
  • InterPro Domains
    IPR026895 ER membrane protein complex subunit 1
    IPR011678 ER membrane protein complex subunit 1, C-terminal
    IPR002372 Pyrrolo-quinoline quinone repeat
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265020 Tang X, et al., EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory