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Arhgap25 Gene Detail
Summary
  • Symbol
    Arhgap25
  • Name
    Rho GTPase activating protein 25
  • Synonyms
    A130039I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443687
    NCBI Gene: 232201
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:87458545-87533259 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74715 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 38.01 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ARHGAP25, Rho GTPase activating protein 25
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP25, Rho GTPase activating protein 25
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-308, KAIA0053
  • Links
    NCBI Gene ID: 9938
    neXtProt AC: NX_P42331
    UniProt: P42331

  • Chr Location
    2p13.3; chr2:68710505-68826833 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered leukocyte transendothelial migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023045 VEGA Gene Model | MGI Sequence Detail 74715 C57BL/6J ±  kb
    transcript OTTMUST00000055535 VEGA | MGI Sequence Detail 3671 Not Applicable  
    polypeptide OTTMUSP00000026601 VEGA | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      570 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 4
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:240521 Csepanyi-Komi R, et al., Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice. J Immunol. 2016 Oct 01;197(7):2807-15

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory