Sipa1l1 MGI Mouse Gene Detail - MGI:2443679 - signal-induced proliferation-associated 1 like 1

Symbol

Sipa1l1
Name

signal-induced proliferation-associated 1 like 1
Synonyms

4931426N11Rik, mKIAA0440, Spar

Feature Type

protein coding gene
IDs

MGI:2443679
NCBI Gene: 217692
Gene Overview

MyGene.info: SIPA1L1
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:82169377-82451786 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.14 cM
Mapping Data

2 experiments

SNPs within 2kb

1788 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443679	protein coding gene	Chr12:82169320-82451786 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019909	protein coding gene	Chr12:82709597-82999115 (+)
A/J	MGP_AJ_G0019866	protein coding gene	Chr12:79615096-79892371 (+)
AKR/J	MGP_AKRJ_G0019842	protein coding gene	Chr12:81766964-82044673 (+)
BALB/cJ	MGP_BALBcJ_G0019846	protein coding gene	Chr12:79945690-80227472 (+)
C3H/HeJ	MGP_C3HHeJ_G0019652	protein coding gene	Chr12:82240066-82515753 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020298	protein coding gene	Chr12:85112536-85404461 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017915	protein coding gene	Chr12:76594534-76869011 (+)
CAST/EiJ	MGP_CASTEiJ_G0019201	protein coding gene	Chr12:77154213-77447796 (+)
CBA/J	MGP_CBAJ_G0019623	protein coding gene	Chr12:88345586-88645232 (+)
DBA/2J	MGP_DBA2J_G0019738	protein coding gene	Chr12:79189320-79466091 (+)
FVB/NJ	MGP_FVBNJ_G0019724	protein coding gene	Chr12:78105914-78389190 (+)
LP/J	MGP_LPJ_G0019810	protein coding gene	Chr12:82604396-82893878 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019763	protein coding gene	Chr12:91419364-91719190 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020332	protein coding gene	Chr12:81353640-81632705 (+)
PWK/PhJ	MGP_PWKPhJ_G0018966	protein coding gene	Chr12:73615118-73897716 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018760	protein coding gene	Chr12:75836646-76126642 (+)
WSB/EiJ	MGP_WSBEiJ_G0019253	protein coding gene	Chr12:82002844-82290493 (+)

Human Ortholog

SIPA1L1, signal induced proliferation associated 1 like 1

Vertebrate Orthologs

10

Human Ortholog

SIPA1L1, signal induced proliferation associated 1 like 1
Orthology source: HomoloGene, HGNC
Synonyms

E6TP1, SPAR1
Links

HGNC:20284

NCBI Gene ID: 26037

neXtProt AC: NX_O43166

UniProt: O43166
Chr Location

14q24.2; chr14:71320418-71741229 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9189
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SIPA1L1
Gene Tree

Sipa1l1

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Gene trapped

68
Targeted

2
Genomic Mutations

1 involving Sipa1l1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

less

All GO Annotations

30
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

38
Tissues

35
cDNA Data

124
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sipa1l1

ZFIN sipa1l1

less

Sipa1l1 interacts with 334 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

less

All Sequences

110
RefSeq

44
UniProt

4
CCDS

CCDS26026.1, CCDS49105.1
UniGene

261333

Ensembl

ENSMUSG00000042700 (Evidence)
NCBI Gene

217692

			Length	Strain/Species	Flank
genomic	217692	NCBI Gene Model \| MGI Sequence Detail	282410	C57BL/6J	± kb
transcript	NM_001167983	RefSeq \| MGI Sequence Detail	7717	C57BL/6
polypeptide	Q8C0T5	UniProt \| EBI \| MGI Sequence Detail	1782	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000014881 signal-induced proliferation-associated 1-like protein 1

(term hierarchy)
InterPro Domains

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR000331 Rap GTPase activating protein domain

IPR035974 Rap/Ran-GAP superfamily

IPR030770 Signal-induced proliferation-associated 1-like protein 1

IPR021818 Signal-induced proliferation-associated 1-like protein, C-terminal

less

All nucleic 124

cDNA 124

Microarray probesets 8

less

MGI:2145019

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 14
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Sipa1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114214	Chr12:82169419-82169443 (+)	54 bp
Tssr114215	Chr12:82169459-82169484 (+)	95 bp
Tssr114216	Chr12:82170146-82170173 (+)	783 bp
Tssr114217	Chr12:82170247-82170304 (+)	899 bp
Tssr114218	Chr12:82170313-82170341 (+)	950 bp
Tssr114228	Chr12:82256576-82256585 (+)	87,204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/18/2020 MGI 6.14