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Sipa1l1 Gene Detail
Summary
  • Symbol
    Sipa1l1
  • Name
    signal-induced proliferation-associated 1 like 1
  • Synonyms
    4931426N11Rik, mKIAA0440, Spar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443679
    NCBI Gene: 217692
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:82216138-82498560 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 38.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9035 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443679
 protein coding gene Chr12:82216094-82498560 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019909
 protein coding gene Chr12:82709597-82999115 (+)
A/J MGP_AJ_G0019866
 protein coding gene Chr12:79615096-79892371 (+)
AKR/J MGP_AKRJ_G0019842
 protein coding gene Chr12:81766964-82044673 (+)
BALB/cJ MGP_BALBcJ_G0019846
 protein coding gene Chr12:79945690-80227472 (+)
C3H/HeJ MGP_C3HHeJ_G0019652
 protein coding gene Chr12:82240066-82515753 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020298
 protein coding gene Chr12:85112536-85404461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017915
 protein coding gene Chr12:76594534-76869011 (+)
CAST/EiJ MGP_CASTEiJ_G0019201
 protein coding gene Chr12:77154213-77447796 (+)
CBA/J MGP_CBAJ_G0019623
 protein coding gene Chr12:88345586-88645232 (+)
DBA/2J MGP_DBA2J_G0019738
 protein coding gene Chr12:79189320-79466091 (+)
FVB/NJ MGP_FVBNJ_G0019724
 protein coding gene Chr12:78105914-78389190 (+)
LP/J MGP_LPJ_G0019810
 protein coding gene Chr12:82604396-82893878 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019763
 protein coding gene Chr12:91419364-91719190 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020332
 protein coding gene Chr12:81353640-81632705 (+)
PWK/PhJ MGP_PWKPhJ_G0018966
 protein coding gene Chr12:73615118-73897716 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018760
 protein coding gene Chr12:75836646-76126642 (+)
WSB/EiJ MGP_WSBEiJ_G0019253
 protein coding gene Chr12:82002844-82290493 (+)



Homology
more
  • Human Ortholog
    SIPA1L1, signal induced proliferation associated 1 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIPA1L1, signal induced proliferation associated 1 like 1
  • Synonyms
    E6TP1, SPAR1
  • Links
    NCBI Gene ID: 26037
    UniProt: O43166

  • Chr Location
    14q24.2; chr14:71320449-71741229 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele show abnormal G-protein-coupled receptor (GPCR) agonist stimulation and multiple behavioral anomalies related to dysregulated GPCR signaling, including hyperactivity, enhanced anxiety, learning impairment, social interaction deficits, and increased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    79
  • cDNA Data
    124
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 217692 NCBI Gene Model | MGI Sequence Detail 282423 C57BL/6J ±  kb
transcript NM_001407403 RefSeq | MGI Sequence Detail 8159 C57BL/6  
polypeptide Q8C0T5 UniProt | EBI | MGI Sequence Detail 1782 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014881 signal-induced proliferation-associated 1-like protein 1
    (term hierarchy)
  • InterPro Domains
    IPR001478 PDZ domain
    IPR036034 PDZ superfamily
    IPR050989 Rap1/Ran GTPase-activating
    IPR000331 Rap/Ran-GAP domain
    IPR035974 Rap/Ran-GAP superfamily
    IPR021818 Signal-induced proliferation-associated 1-like protein, C-terminal
  • GlyGen
    Q8C0T5 20 sites, 3 N-linked glycans (4 sites), 1 O-linked glycan (13 sites)
Molecular
Reagents
less
  • All nucleic 125
    cDNA 124
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2145019
References
more
  • Summaries
    All 54
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory