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Slc12a8 Gene Detail
Summary
  • Symbol
    Slc12a8
  • Name
    solute carrier family 12 (potassium/chloride transporters), member 8
  • Synonyms
    E330020C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443672
    NCBI Gene: 171286
  • Gene Overview
    MyGene.info: SLC12A8
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:33517333-33664135 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    882 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443672
protein coding gene Chr16:33517328-33664135 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022756
protein coding gene Chr16:31729844-31879451 (+)
A/J MGP_AJ_G0022721
protein coding gene Chr16:30206566-30350595 (+)
AKR/J MGP_AKRJ_G0022694
protein coding gene Chr16:31274471-31421111 (+)
BALB/cJ MGP_BALBcJ_G0022723
protein coding gene Chr16:30315588-30461800 (+)
C3H/HeJ MGP_C3HHeJ_G0022488
protein coding gene Chr16:31398460-31549495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023172
protein coding gene Chr16:32425655-32585204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020690
protein coding gene Chr16:30543417-30695708 (+)
CAST/EiJ MGP_CASTEiJ_G0022016
protein coding gene Chr16:31564468-31727361 (+)
CBA/J MGP_CBAJ_G0022458
protein coding gene Chr16:33725688-33885825 (+)
DBA/2J MGP_DBA2J_G0022591
protein coding gene Chr16:30022476-30175038 (+)
FVB/NJ MGP_FVBNJ_G0022566
protein coding gene Chr16:30016663-30165814 (+)
LP/J MGP_LPJ_G0022658
protein coding gene Chr16:31462575-31613555 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022585
protein coding gene Chr16:33113215-33268823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023184
protein coding gene Chr16:31277141-31428912 (+)
PWK/PhJ MGP_PWKPhJ_G0021757
protein coding gene Chr16:30408833-30548742 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021586
protein coding gene Chr16:31063172-31218420 (+)
WSB/EiJ MGP_WSBEiJ_G0022060
protein coding gene Chr16:31241579-31393629 (+)



Homology
more
  • Human Ortholog
    SLC12A8, solute carrier family 12 member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC12A8, solute carrier family 12 member 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCC9
  • Links
    NCBI Gene ID: 84561
    neXtProt AC: NX_A0AV02
    UniProt: A0AV02

  • Chr Location
    3q21.2; chr3:125082636-125212765 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 171286 NCBI Gene Model | MGI Sequence Detail 146803 C57BL/6J ±  kb
transcript NM_134251 RefSeq | MGI Sequence Detail 3166 C57BL/6  
polypeptide Q8VI23 UniProt | EBI | MGI Sequence Detail 705 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory