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Ccdc66
Gene Detail
Symbol

Name
ID
Ccdc66
coiled-coil domain containing 66
MGI:2443639
Synonyms
E230015L20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
16.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:27482412-27508460 bp, - strand
From Ensembl annotation of GRCm38

  26049 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCDC66
Gene Tree: Ccdc66

Human
homologs
CCDC66, coiled-coil domain containing 66
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 285331
neXtProt AC: NX_A2RUB6

Human Chr (Location): 3p14.3; chr3:56557111-56621836 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display slowly progressing photoreceptor degeneration.
 
Human Diseases Modeled in Mice Using Ccdc66 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ccdc66 interacts with 70 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process post-embryonic retina morphogenesis in camera-type eye, retinal rod cell development
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (71)    Tissues (37)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccdc66    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000046753 (Evidence)
Entrez Gene 320234 (Evidence)
DFCI TC1596483, TC1581129, TC1585329
DoTS DT.97393935, DT.99838851, DT.94226106, DT.94129024, DT.101226199
NIA Mouse Gene Index U035342
Consensus CDS Project CCDS36843.1
International Mouse Phenotyping Consortium Status Ccdc66
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046753 Ensembl Gene Model | MGI Sequence Detail 26049 C57BL/6J ±  kb
transcript ENSMUST00000050480 Ensembl | MGI Sequence Detail 2940 Not Applicable 
polypeptide ENSMUSP00000052546 Ensembl | MGI Sequence Detail 935 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000029334 coiled-coil domain-containing protein 66
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:174954 Gerding WM, et al., Ccdc66 null mutation causes retinal degeneration and dysfunction. Hum Mol Genet. 2011 Sep 15;20(18):3620-31
All references(27)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory