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Ccdc66 Gene Detail
Summary
  • Symbol
    Ccdc66
  • Name
    coiled-coil domain containing 66
  • Synonyms
    E230015L20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443639
    NCBI Gene: 320234
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:27481090-27508460 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443639
protein coding gene Chr14:27480911-27508506 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021093
protein coding gene Chr14:20497155-20523191 (-)
A/J MGP_AJ_G0021041
protein coding gene Chr14:19698272-19724307 (-)
AKR/J MGP_AKRJ_G0021018
protein coding gene Chr14:20756625-20782662 (-)
BALB/cJ MGP_BALBcJ_G0021045
protein coding gene Chr14:19810601-19836622 (-)
C3H/HeJ MGP_C3HHeJ_G0020828
protein coding gene Chr14:20617928-20644709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021477
protein coding gene Chr14:21361531-21388118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019040
protein coding gene Chr14:19821112-19847846 (-)
CAST/EiJ MGP_CASTEiJ_G0020353
protein coding gene Chr14:20262257-20289397 (-)
CBA/J MGP_CBAJ_G0020795
protein coding gene Chr14:22199014-22229552 (-)
DBA/2J MGP_DBA2J_G0020917
protein coding gene Chr14:19770962-19798194 (-)
FVB/NJ MGP_FVBNJ_G0020901
protein coding gene Chr14:19731588-19757601 (-)
LP/J MGP_LPJ_G0020986
protein coding gene Chr14:20811702-20837637 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020927
protein coding gene Chr14:21537345-21564395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021510
protein coding gene Chr14:20514629-20540646 (-)
PWK/PhJ MGP_PWKPhJ_G0020101
protein coding gene Chr14:19193943-19220011 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019925
protein coding gene Chr14:20007811-20034012 (-)
WSB/EiJ MGP_WSBEiJ_G0020408
protein coding gene Chr14:20570274-20596687 (-)



Homology
more
  • Human Ortholog
    CCDC66, coiled-coil domain containing 66
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCDC66, coiled-coil domain containing 66
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 285331
    neXtProt AC: NX_A2RUB6
    UniProt: A2RUB6

  • Chr Location
    3p14.3; chr3:56557125-56621837 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 35309
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CCDC66
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ccdc66 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display slowly progressing photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046753 Ensembl Gene Model | MGI Sequence Detail 27371 C57BL/6J ±  kb
    transcript ENSMUST00000223689 Ensembl | MGI Sequence Detail 4262 Not Applicable  
    polypeptide ENSMUSP00000153023 Ensembl | MGI Sequence Detail 935 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:174954 Gerding WM, et al., Ccdc66 null mutation causes retinal degeneration and dysfunction. Hum Mol Genet. 2011 Sep 15;20(18):3620-31

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory