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Pou6f2
Gene Detail
Symbol

Name
ID
Pou6f2
POU domain, class 6, transcription factor 2
MGI:2443631
Synonyms
D130006K24Rik, RPF-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
6.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:18121101-18382041 bp, - strand
From VEGA annotation of GRCm38

  260941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HCOP human homology predictions: POU6F2
Protein SuperFamily: POU domain class 6 transcription factor 2
Gene Tree: Pou6f2
Human
homologs
POU6F2, POU class 6 homeobox 2
Orthology source: HGNC

IDs:
NCBI Gene ID: 11281
neXtProt AC: NX_P78424

Human Synonyms: RPF-1, WT5, WTSL

Human Chr (Location): 7p14.1; chr7:38977904-39468601 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human POU6F2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Radiation induced(1) Targeted(3)
Genomic Mutations involving Pou6f2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.
 
Interactions
Pou6f2 interacts with 454 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (130)    Tissues (37)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 120
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA POU6F2 ; Xenbase pou6f2 ; ZFIN pou6f2    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000029195 (Evidence)
Ensembl Gene Model ENSMUSG00000009734 (Evidence)
Entrez Gene 218030 (Evidence)
UniGene 352263
DFCI TC1589482, TC1586119, TC1590836
DoTS DT.91332371, DT.55115207, DT.101190637
NIA Mouse Gene Index U034538
International Mouse Phenotyping Consortium Status Pou6f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029195 VEGA Gene Model | MGI Sequence Detail 260941 C57BL/6J ±  kb
transcript OTTMUST00000072394 VEGA | MGI Sequence Detail 5974 Not Applicable 
polypeptide OTTMUSP00000037254 VEGA | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(1975 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1979)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013047 POU domain, class 6, transcription factor 2
References
(Earliest) J:107704 Xiang M, Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol. 1998 May 15;197(2):155-69
(Latest) J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory