Pou6f2
Gene Detail

Symbol Name ID

Pou6f2 POU domain, class 6, transcription factor 2 MGI:2443631

Synonyms

D130006K24Rik, RPF-1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

6.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:18121101-18382041 bp, - strand From VEGA annotation of GRCm38   260941 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5245  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: POU domain class 6 transcription factor 2
Gene Tree: Pou6f2

Human homologs

Human Homolog		POU6F2, POU class 6 homeobox 2
NCBI Gene ID		11281
neXtProt AC		NX_P78424
Human Synonyms		RPF-1, WT5, WTSL
Human Chr (Location)		7p14.1; chr7:39017609-39504390 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human POU6F2

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)
 

Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	regulation of transcription, DNA-dependent, transcription, DNA-dependent
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (130)    Tissues (37)    Images (33)
Theiler Stages: 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	120

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000029195 (Evidence)
Ensembl Gene Model	ENSMUSG00000009734 (Evidence)
Entrez Gene	218030 (Evidence)
UniGene	352263
DFCI	TC1586119, TC1589482, TC1590836
DoTS	DT.101190637, DT.55115207, DT.91332371
NIA Mouse Gene Index	U034538
International Mouse Knockout Project Status	Pou6f2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029195	VEGA Gene Model | MGI Sequence Detail	260941	C57BL/6J
transcript	OTTMUST00000072394	VEGA | MGI Sequence Detail	5974	Not Applicable
polypeptide	OTTMUSP00000037254	VEGA | MGI Sequence Detail	637	Not Applicable

All sequences(46) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(1454 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR010982	Lambda repressor-like, DNA-binding domain
InterPro	IPR013847	POU domain
InterPro	IPR000327	POU-specific
Protein Ontology	PR:000013047	POU domain, class 6, transcription factor 2

References

(Earliest) J:107704 Xiang M, Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol. 1998 May 15;197(2):155-69
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)