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Pou6f2 Gene Detail
Summary
  • Symbol
    Pou6f2
  • Name
    POU domain, class 6, transcription factor 2
  • Synonyms
    D130006K24Rik, RPF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443631
    NCBI Gene: 218030
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:18121101-18382041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      260941 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
    Orthology source: HGNC
  • Synonyms
    RPF-1, WT5, WTSL
  • Links
    NCBI Gene ID: 11281
    neXtProt AC: NX_P78424
    UniProt: P78424

  • Chr Location
    7p14.1; chr7:38977878-39468601 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029195 VEGA Gene Model | MGI Sequence Detail 260941 C57BL/6J ±  kb
transcript OTTMUST00000072394 VEGA | MGI Sequence Detail 5974 Not Applicable  
polypeptide OTTMUSP00000037254 VEGA | MGI Sequence Detail 637 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1952 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR001356 Homeobox domain
    IPR009057 Homeobox-like domain superfamily
    IPR010982 Lambda repressor-like, DNA-binding domain superfamily
    IPR013847 POU domain
    IPR033056 POU domain, class 6, transcription factor 2
    IPR000327 POU-specific domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 11
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:107704 Xiang M, Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol. 1998 May 15;197(2):155-69
  • Latest
    J:256989 King R, et al., Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. PLoS Genet. 2018 Jan;14(1):e1007145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory