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Pou6f2 Gene Detail
Summary
  • Symbol
    Pou6f2
  • Name
    POU domain, class 6, transcription factor 2
  • Synonyms
    D130006K24Rik, RPF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443631
    NCBI Gene: 218030
Location & Maps
more
  • Sequence Map
    Chr13:18121101-18382041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      260941 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
    Orthology source: HGNC
  • Synonyms
    RPF-1, WT5, WTSL
  • Links
    NCBI Gene ID: 11281
    neXtProt AC: NX_P78424

  • Chr Location
    7p14.1; chr7:38977904-39468601 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human POU6F2 associations

Human Disease Mouse Models
       Wilms Tumor 5; WT5   OMIM: 601583
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
  • All Mutations and Alleles
    7
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Pou6f2
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029195 VEGA Gene Model | MGI Sequence Detail 260941 C57BL/6J ±  kb
transcript OTTMUST00000072394 VEGA | MGI Sequence Detail 5974 Not Applicable  
polypeptide OTTMUSP00000037254 VEGA | MGI Sequence Detail 637 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1952 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 8
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:107704 Xiang M, Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol. 1998 May 15;197(2):155-69
  • Latest
    J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory