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Pou6f2 Gene Detail
Summary
  • Symbol
    Pou6f2
  • Name
    POU domain, class 6, transcription factor 2
  • Synonyms
    D130006K24Rik, RPF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443631
    NCBI Gene: 218030
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr13:18124960-18382044 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1933 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443631
protein coding gene Chr13:18121098-18397686 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020255
protein coding gene Chr13:15202808-15473035 (-)
A/J MGP_AJ_G0020212
protein coding gene Chr13:15006114-15283012 (-)
AKR/J MGP_AKRJ_G0020186
protein coding gene Chr13:15186267-15459385 (-)
BALB/cJ MGP_BALBcJ_G0020198
protein coding gene Chr13:14974472-15363928 (-)
C3H/HeJ MGP_C3HHeJ_G0020001
protein coding gene Chr13:15305701-15695475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020642
protein coding gene Chr13:15886943-16275520 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018249
protein coding gene Chr13:13486651-13754563 (-)
CAST/EiJ MGP_CASTEiJ_G0019536
protein coding gene Chr13:15024469-15320142 (-)
CBA/J MGP_CBAJ_G0019965
protein coding gene Chr13:16411872-16816913 (-)
DBA/2J MGP_DBA2J_G0020084
protein coding gene Chr13:14594194-14855997 (-)
FVB/NJ MGP_FVBNJ_G0020066
protein coding gene Chr13:14296604-14565679 (-)
LP/J MGP_LPJ_G0020155
protein coding gene Chr13:15475560-15756196 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020104
protein coding gene Chr13:16773901-17178784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020671
protein coding gene Chr13:15010630-15278464 (-)
PWK/PhJ MGP_PWKPhJ_G0019299
protein coding gene Chr13:14642566-15036171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019105
protein coding gene Chr13:14146074-14418826 (-)
WSB/EiJ MGP_WSBEiJ_G0019595
protein coding gene Chr13:15031150-15420922 (-)



Homology
more
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
    Orthology source: HGNC
  • Synonyms
    RPF-1, WT5, WTSL
  • Links
    NCBI Gene ID: 11281
    neXtProt AC: NX_P78424
    UniProt: P78424

  • Chr Location
    7p14.1; chr7:38977878-39468601 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 218030 NCBI Gene Model | MGI Sequence Detail 257085 C57BL/6J ±  kb
transcript NM_175006 RefSeq | MGI Sequence Detail 2403 C57BL/6  
polypeptide Q8BJI4 UniProt | EBI | MGI Sequence Detail 691 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 11
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:107704 Xiang M, Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol. 1998 May 15;197(2):155-69
  • Latest
    J:256989 King R, et al., Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. PLoS Genet. 2018 Jan;14(1):e1007145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory