Gpr149 MGI Mouse Gene Detail - MGI:2443628 - G protein-coupled receptor 149

Symbol

Gpr149
Name

G protein-coupled receptor 149
Synonyms

9630018L10Rik, Ieda, PGR10, R35

Feature Type

protein coding gene
IDs

MGI:2443628
NCBI Gene: 229357
Alliance

genome feature page

Sequence Map

Chr3:62436851-62512861 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 29.97 cM
Mapping Data

1 experiment

SNPs within 2kb

1974 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443628	protein coding gene	Chr3:62436498-62512861 (-)
129S1/SvImJ	ENSMUSG00200022773	protein coding gene	Chr3:59351965-59428016 (-)
A/J	ENSMUSG00195029930	protein coding gene	Chr3:59297705-59373774 (-)
AKR/J	ENSMUSG00220027711	protein coding gene	Chr3:57305821-57382066 (+)
BALB/cJ	ENSMUSG00180025586	protein coding gene	Chr3:59348934-59425187 (-)
C3H/HeJ	ENSMUSG00175008487	protein coding gene	Chr3:59189034-59265092 (-)
C57BL/6NJ	ENSMUSG00215005682	protein coding gene	Chr3:59630895-59706967 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025033	protein coding gene	Chr3:56224519-56289346 (-)
CAST/EiJ	ENSTCUG00005002314	protein coding gene	Chr3:58955217-59031317 (-)
CBA/J	ENSMUSG00210003451	protein coding gene	Chr3:59298595-59374647 (-)
DBA/2J	ENSMUSG00185026978	protein coding gene	Chr3:59448932-59519892 (-)
FVB/NJ	ENSMUSG00205003130	protein coding gene	Chr3:58424188-58500279 (-)
JF1/MsJ	ENSUMUG00000001333	protein coding gene	Chr3:59159979-59226181 (-)
LP/J	ENSMUSG00230002053	protein coding gene	Chr3:61488676-61564739 (-)
NOD/ShiLtJ	ENSMUSG00190024953	protein coding gene	Chr3:59727398-59803643 (-)
NZO/HlLtJ	ENSMUSG00225002120	protein coding gene	Chr3:64091022-64167082 (-)
PWK/PhJ	ENSLUMG00010005175	protein coding gene	Chr3:58956325-59022464 (-)
SPRET/EiJ	ENSMSPG00010007484	protein coding gene	Chr3:59739638-59823070 (-)
WSB/EiJ	ENSIUOG00005007935	protein coding gene	Chr3:59444169-59520264 (-)

Human Ortholog

GPR149, G protein-coupled receptor 149

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR149, G protein-coupled receptor 149
Synonyms

IEDA, PGR10, R35
Links

HGNC:23627

NCBI Gene ID: 344758

UniProt: Q86SP6
Chr Location

3q25.2; chr3:154334943-154430190 (-) GRCh38

MGI Vertebrate Homology

Gpr149 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPR149
Gene Tree

Gpr149

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Gpr149
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr149

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS17380.1

Ensembl

ENSMUSG00000043441 (Evidence)
NCBI Gene

229357

			Length	Strain/Species	Flank
genomic	229357	NCBI Gene Model \| MGI Sequence Detail	76011	C57BL/6J	± kb
transcript	NM_001356525	RefSeq \| MGI Sequence Detail	4316	C57BL/6
polypeptide	Q3UVY1	UniProt \| EBI \| MGI Sequence Detail	732	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001511 probable G-protein coupled receptor 149

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR059833 G-protein coupled receptor 149, C-terminal domain
GlyGen

Q3UVY1 2 sites

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All nucleic 8

Genomic 2

cDNA 6

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 15
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:340028 Suo N, et al., The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022 Oct;70(10):1992-2008

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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