Plekhm3 MGI Mouse Gene Detail - MGI:2443627 - pleckstrin homology domain containing, family M, member 3

Symbol

Plekhm3
Name

pleckstrin homology domain containing, family M, member 3
Synonyms

9430067K14Rik, A230102O09Rik, Plekhm1l

Feature Type

protein coding gene
IDs

MGI:2443627
NCBI Gene: 241075
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:64789120-64956824 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.76 cM
Mapping Data

2 experiments

SNPs within 2kb

972 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443627	protein coding gene	Chr1:64785983-64956824 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016099	protein coding gene	Chr1:64971533-65140654 (-)
A/J	MGP_AJ_G0016082	protein coding gene	Chr1:62683509-62851716 (-)
AKR/J	MGP_AKRJ_G0016039	protein coding gene	Chr1:64444274-64619499 (-)
BALB/cJ	MGP_BALBcJ_G0016037	protein coding gene	Chr1:62778907-62950423 (-)
C3H/HeJ	MGP_C3HHeJ_G0015869	protein coding gene	Chr1:64713840-64886159 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016490	protein coding gene	Chr1:67484036-67658902 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014211	protein coding gene	Chr1:58740487-58912661 (-)
CAST/EiJ	MGP_CASTEiJ_G0015452	protein coding gene	Chr1:63978896-64154101 (-)
CBA/J	MGP_CBAJ_G0015841	protein coding gene	Chr1:69680959-69864914 (-)
DBA/2J	MGP_DBA2J_G0015942	protein coding gene	Chr1:62086886-62258079 (-)
FVB/NJ	MGP_FVBNJ_G0015945	protein coding gene	Chr1:61363340-61532509 (-)
LP/J	MGP_LPJ_G0016014	protein coding gene	Chr1:65876282-66049311 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015965	protein coding gene	Chr1:72541018-72718916 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016537	protein coding gene	Chr1:64424545-64594434 (-)
PWK/PhJ	MGP_PWKPhJ_G0015239	protein coding gene	Chr1:61480373-61651983 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015018	protein coding gene	Chr1:63906888-64081383 (-)
WSB/EiJ	MGP_WSBEiJ_G0015514	protein coding gene	Chr1:64129754-64304160 (-)

Human Ortholog

PLEKHM3, pleckstrin homology domain containing M3

Vertebrate Orthologs

9

Human Ortholog

PLEKHM3, pleckstrin homology domain containing M3
Orthology source: HomoloGene, HGNC
Synonyms

DAPR, PLEKHM1L
Links

HGNC:34006

NCBI Gene ID: 389072

neXtProt AC: NX_Q6ZWE6

UniProt: Q6ZWE6
Chr Location

2q33.3; chr2:207821288-208025675 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 18459
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PLEKHM3
Gene Tree

Plekhm3

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Plekhm3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

7
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plekhm3

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Plekhm3 interacts with 508 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

48
RefSeq

6
UniProt

2
CCDS

CCDS15009.1

Ensembl

ENSMUSG00000051344 (Evidence)
NCBI Gene

241075

			Length	Strain/Species	Flank
genomic	241075	NCBI Gene Model \| MGI Sequence Detail	167705	C57BL/6J	± kb
transcript	NM_001039493	RefSeq \| MGI Sequence Detail	8562	Not Specified
polypeptide	Q8BM47	UniProt \| EBI \| MGI Sequence Detail	761	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029679 pleckstrin homology domain-containing family M member 3

(term hierarchy)
InterPro Domains

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR037812 PLEKHM3, PH domain 1

IPR025258 Putative zinc-RING and/or ribbon

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All nucleic 10

cDNA 10

Microarray probesets 5

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MGI:2138249

Summaries

All 28

Gene Ontology 2

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:261835 Virtanen C, et al., Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. J Biol Chem. 2009 Jan 16;284(3):1636-43

TSS for Plekhm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11948	Chr1:64956823-64956835 (-)	-5 bp
Tssr11947	Chr1:64956807-64956818 (-)	11 bp
Tssr11946	Chr1:64956731-64956782 (-)	67 bp
Tssr11945	Chr1:64956711-64956725 (-)	106 bp
Tssr11941	Chr1:64928112-64928115 (-)	28,710 bp
Tssr11940	Chr1:64928076-64928096 (-)	28,738 bp
Tssr11939	Chr1:64928061-64928066 (-)	28,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16