Plekhm3 Gene Detail

Summary

• Symbol
  Plekhm3
• Name
  pleckstrin homology domain containing, family M, member 3
• Synonyms
  9430067K14Rik, A230102O09Rik, Plekhm1l

• Feature Type
  protein coding gene
• IDs
  MGI:2443627
  NCBI Gene: 241075
• Alliance
  gene page
• Transcription Start Sites
  14 TSS

Location &
Maps

• Sequence Map
  Chr1:64828279-64995983 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 32.76 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  4507 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443627	protein coding gene	Chr1:64825142-64995983 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016099	protein coding gene	Chr1:64971533-65140654 (-)
A/J	MGP_AJ_G0016082	protein coding gene	Chr1:62683509-62851716 (-)
AKR/J	MGP_AKRJ_G0016039	protein coding gene	Chr1:64444274-64619499 (-)
BALB/cJ	MGP_BALBcJ_G0016037	protein coding gene	Chr1:62778907-62950423 (-)
C3H/HeJ	MGP_C3HHeJ_G0015869	protein coding gene	Chr1:64713840-64886159 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016490	protein coding gene	Chr1:67484036-67658902 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014211	protein coding gene	Chr1:58740487-58912661 (-)
CAST/EiJ	MGP_CASTEiJ_G0015452	protein coding gene	Chr1:63978896-64154101 (-)
CBA/J	MGP_CBAJ_G0015841	protein coding gene	Chr1:69680959-69864914 (-)
DBA/2J	MGP_DBA2J_G0015942	protein coding gene	Chr1:62086886-62258079 (-)
FVB/NJ	MGP_FVBNJ_G0015945	protein coding gene	Chr1:61363340-61532509 (-)
LP/J	MGP_LPJ_G0016014	protein coding gene	Chr1:65876282-66049311 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015965	protein coding gene	Chr1:72541018-72718916 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016537	protein coding gene	Chr1:64424545-64594434 (-)
PWK/PhJ	MGP_PWKPhJ_G0015239	protein coding gene	Chr1:61480373-61651983 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015018	protein coding gene	Chr1:63906888-64081383 (-)
WSB/EiJ	MGP_WSBEiJ_G0015514	protein coding gene	Chr1:64129754-64304160 (-)

Homology

• Human Ortholog
  PLEKHM3, pleckstrin homology domain containing M3

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PLEKHM3, pleckstrin homology domain containing M3
  
• Synonyms
  DAPR, PLEKHM1L
• Links
  HGNC:34006

  NCBI Gene ID: 389072

  UniProt: Q6ZWE6

  
  
• Chr Location
  2q33.3; chr2:207821288-208025527 (-)  GRCh38

---

• MGI Vertebrate Homology
  Plekhm3 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: PLEKHM3
• Gene Tree
  Plekhm3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Gene trapped
  2
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Plekhm3
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  34 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  10

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase plekhm3

Sequences &
Gene Models

• All Sequences
  49
• RefSeq
  7
• UniProt
  2
• CCDS
  CCDS15009.1

• Ensembl
  ENSMUSG00000051344 (Evidence)
• NCBI Gene
  241075

Representative Sequences			Length	Strain/Species
genomic	241075	NCBI Gene Model | MGI Sequence Detail	167705	C57BL/6J
transcript	NM_001431259	RefSeq | MGI Sequence Detail	8563	C57BL/6
polypeptide	Q8BM47	UniProt | EBI | MGI Sequence Detail	761	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000029679 pleckstrin homology domain-containing family M member 3
  (term hierarchy)
• InterPro Domains
  IPR051366 Differentially Expressed in FDCP 8 Homolog
  IPR011993 PH-like domain superfamily
  IPR001849 Pleckstrin homology domain
  IPR037812 PLEKHM3, PH domain 1
  IPR025258 Rubicon Homology Domain

Molecular
Reagents

• All nucleic 10

  cDNA 10

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:2138249

References

• Summaries
  All 27

  Phenotypes 8
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:261835 Virtanen C, et al., Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. J Biol Chem. 2009 Jan 16;284(3):1636-43

TSS for Plekhm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11948	Chr1:64995982-64995994 (-)	-5 bp
Tssr11947	Chr1:64995966-64995977 (-)	11 bp
Tssr11946	Chr1:64995890-64995941 (-)	67 bp
Tssr11945	Chr1:64995870-64995884 (-)	106 bp
Tssr11944	Chr1:64976983-64976995 (-)	18,994 bp
Tssr11943	Chr1:64976967-64976980 (-)	19,009 bp
Tssr11942	Chr1:64967801-64967805 (-)	28,180 bp
Tssr11941	Chr1:64967271-64967274 (-)	28,710 bp
Tssr11940	Chr1:64967235-64967255 (-)	28,738 bp
Tssr11939	Chr1:64967220-64967225 (-)	28,760 bp
Tssr11938	Chr1:64966658-64966699 (-)	29,304 bp
Tssr11937	Chr1:64964102-64964109 (-)	31,877 bp
Tssr11936	Chr1:64855834-64855849 (-)	140,141 bp
Tssr11935	Chr1:64852125-64852152 (-)	143,844 bp