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Tmem203 Gene Detail
Summary
  • Symbol
    Tmem203
  • Name
    transmembrane protein 203
  • Synonyms
    C730025P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443597
    NCBI Gene: 227615
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25255439-25256292 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443597
protein coding gene Chr2:25255439-25256352 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025432
protein coding gene Chr2:23123237-23124090 (+)
A/J MGP_AJ_G0025409
protein coding gene Chr2:22234828-22235681 (+)
AKR/J MGP_AKRJ_G0025379
protein coding gene Chr2:22976727-22977580 (+)
BALB/cJ MGP_BALBcJ_G0025405
protein coding gene Chr2:22344678-22345531 (+)
C3H/HeJ MGP_C3HHeJ_G0025166
protein coding gene Chr2:22904947-22905800 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025849
protein coding gene Chr2:23854863-23855716 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023260
protein coding gene Chr2:21152943-21153794 (+)
CAST/EiJ MGP_CASTEiJ_G0024629
protein coding gene Chr2:22787831-22788676 (+)
CBA/J MGP_CBAJ_G0025144
protein coding gene Chr2:24694720-24695573 (+)
DBA/2J MGP_DBA2J_G0025277
protein coding gene Chr2:22077446-22078299 (+)
FVB/NJ MGP_FVBNJ_G0025239
protein coding gene Chr2:21817332-21818185 (+)
LP/J MGP_LPJ_G0025363
protein coding gene Chr2:23066290-23067143 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025270
protein coding gene Chr2:24896807-24897660 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025908
protein coding gene Chr2:22924851-22925704 (+)
PWK/PhJ MGP_PWKPhJ_G0024377
protein coding gene Chr2:21888822-21889673 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024177
protein coding gene Chr2:23080486-23081337 (+)
WSB/EiJ MGP_WSBEiJ_G0024698
protein coding gene Chr2:22994562-22995415 (+)



Homology
more
  • Human Ortholog
    TMEM203, transmembrane protein 203
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEM203, transmembrane protein 203
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HBEBP1
  • Links
    NCBI Gene ID: 94107
    neXtProt AC: NX_Q969S6
    UniProt: Q969S6

  • Chr Location
    9q34.3; chr9:137204082-137205638 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, abnormal calcium homeostasis, arreasted spermiation, azoospermia, male infertility and reduced total litter numbers in female mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078201 Ensembl Gene Model | MGI Sequence Detail 854 C57BL/6J ±  kb
transcript ENSMUST00000104998 Ensembl | MGI Sequence Detail 854 Not Applicable  
polypeptide ENSMUSP00000100614 Ensembl | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 25
    cDNA 25

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:222925 Shambharkar PB, et al., TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS One. 2015;10(5):e0127480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory