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Tmem203 Gene Detail
Summary
  • Symbol
    Tmem203
  • Name
    transmembrane protein 203
  • Synonyms
    C730025P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443597
    NCBI Gene: 227615
Location & Maps
more
  • Genetic Map
    Chromosome 2, 17.11 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    TMEM203, transmembrane protein 203
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEM203, transmembrane protein 203
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HBEBP1
  • Links
    NCBI Gene ID: 94107
    neXtProt AC: NX_Q969S6

  • Chr Location
    9q34.3; chr9:137204082-137205638 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit reduced body weight, abnormal calcium homeostasis, arreasted spermiation, azoospermia, male infertility and reduced total litter numbers in female mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011903 VEGA Gene Model | MGI Sequence Detail 854 C57BL/6J ±  kb
transcript OTTMUST00000028084 VEGA | MGI Sequence Detail 854 Not Applicable  
polypeptide OTTMUSP00000012724 VEGA | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032381 transmembrane protein 203
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:222925 Shambharkar PB, et al., TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS One. 2015;10(5):e0127480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory