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Ddx11
Gene Detail
 Symbol
Name
ID
Ddx11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
MGI:2443590
Synonyms 4732462I11Rik, CHL1, CHLR1, essa15a, KRG2
Feature Type protein coding gene
Genetic Map
Chromosome 17
35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:66123520-66152167 bp, + strand
From Ensembl annotation of GRCm38

  28648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ddx11

Human
homologs
Human Homolog DDX11, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
NCBI Gene ID 1663
neXtProt AC  NX_Q96FC9
Human Synonyms  CHL1, CHLR1, KRG2, WABS
Human Chr (Location)  12p11; chr12:31073845-31104799 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DDX11
Alleles
and
phenotypes
All alleles(18) : Targeted(3) Gene trapped(14) Chemically induced(1)
 
Mice homozygous for a null allele exhibit lethality before E11.5 with growth retardation, failure of chorioallantoic fusion, poor placental labyrinth development, and embryonic cell physiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process ATP catabolic process, cell cycle, ...
Component midbody, nuclear chromatin, ...
Function 4 iron, 4 sulfur cluster binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (5)    Images (4)
Theiler Stages: 13, 15, 28
Assay TypeResults
RNA in situ 6
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(30) cDNA(29) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000035842 (Evidence)
Entrez Gene320209 (Evidence)
UniGene259605
DFCITC1582172, TC1610307, TC1623044
DoTSDT.101724100, DT.110557079, DT.481770, DT.94145231
NIA Mouse Gene IndexU043618
EC3.6.4.13
Consensus CDS ProjectCCDS28945.1
International Mouse Knockout Project StatusDdx11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035842 Ensembl Gene Model | MGI Sequence Detail 28648 C57BL/6J ±  kb
transcript ENSMUST00000163605 Ensembl | MGI Sequence Detail 4149 Not Applicable 
polypeptide ENSMUSP00000130440 Ensembl | MGI Sequence Detail 880 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(11) UniProt(2)
Polymorphisms SNPs within 2kb(151 from dbSNP Build 137)    SNPs within 2kb including multiple locations(169)
Protein-related
information
ResourceIDDescription
InterPro IPR006555 ATP-dependent helicase, C-terminal
InterPro IPR010614 DEAD2
InterPro IPR013020 DNA helicase (DNA repair), Rad3 type
InterPro IPR006554 Helicase-like, DEXD box c2 type
InterPro IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000029382 ATP-dependent RNA helicase DDX11
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185600 Cota CD, et al., The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Dev Dyn. 2012 Aug;241(8):1249-59
All references(35)
Other
accession IDs
MGI:3578202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory