Ddx11
Gene Detail

Symbol Name ID

Ddx11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 MGI:2443590

Synonyms

4732462I11Rik, CHL1, CHLR1, essa15a, KRG2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:66123520-66152167 bp, + strand From Ensembl annotation of GRCm38   28648 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ddx11

Human homologs

Human Homolog		DDX11, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
NCBI Gene ID		1663
neXtProt AC		NX_Q96FC9
Human Synonyms		CHL1, CHLR1, KRG2, WABS
Human Chr (Location)		12p11; chr12:31226779-31257725 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DDX11

Alleles and phenotypes

All alleles(18) : Targeted(3) Gene trapped(14) Chemically induced(1)
 

Mice homozygous for a null allele exhibit lethality before E11.5 with growth retardation, failure of chorioallantoic fusion, poor placental labyrinth development, and embryonic cell physiology.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell cycle, nucleobase-containing compound metabolic process, ...
Component	midbody, nuclear chromatin, ...
Function	4 iron, 4 sulfur cluster binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (5)    Images (4)
Theiler Stages: 13, 15, 28

Assay Type	Results
RNA in situ	6

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(29) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000035842 (Evidence)
Entrez Gene	320209 (Evidence)
UniGene	259605
DFCI	TC1582172, TC1610307, TC1623044
DoTS	DT.101724100, DT.110557079, DT.481770, DT.94145231
NIA Mouse Gene Index	U043618
EC	3.6.4.13
Consensus CDS Project	CCDS28945.1
International Mouse Knockout Project Status	Ddx11

Sequences

Length	Strain/Species
genomic	ENSMUSG00000035842	Ensembl Gene Model | MGI Sequence Detail	28648	C57BL/6J
transcript	ENSMUST00000163605	Ensembl | MGI Sequence Detail	4149	Not Applicable
polypeptide	ENSMUSP00000130440	Ensembl | MGI Sequence Detail	880	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(111 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006555	ATP-dependent helicase, C-terminal
InterPro	IPR010614	DEAD2
InterPro	IPR013020	DNA helicase (DNA repair), Rad3 type
InterPro	IPR006554	Helicase-like, DEXD box c2 type
InterPro	IPR014013	Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
Protein Ontology	PR:000029382	ATP-dependent RNA helicase DDX11

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185600 Cota CD, et al., The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Dev Dyn. 2012 Aug;241(8):1249-59
All references(35)

Other accession IDs

MGI:3578202