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Ddx11 Gene Detail
Summary
  • Symbol
    Ddx11
  • Name
    DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
  • Synonyms
    4732462I11Rik, CHL1, CHLR1, essa15a, KRG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443590
    NCBI Gene: 320209
  • Gene Overview
    MyGene.info: DDX11
Location & Maps
more
  • Sequence Map
    Chr17:66123520-66152167 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28648 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DDX11, DEAD/H-box helicase 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX11, DEAD/H-box helicase 11
    Orthology source: HomoloGene
  • Synonyms
    CHL1, CHLR1, KRG2, WABS
  • Links
    NCBI Gene ID: 1663
    neXtProt AC: NX_Q96FC9

  • Chr Location
    12p11; chr12:31073581-31104799 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68973
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DDX11
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DDX11 associations

Human Disease Mouse Models
       Warsaw Breakage Syndrome; WABS   OMIM: 613398
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Gene trapped
    14
  • Targeted
    3
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit lethality before E11.5 with growth retardation, failure of chorioallantoic fusion, poor placental labyrinth development, and embryonic cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035842 Ensembl Gene Model | MGI Sequence Detail 28648 C57BL/6J ±  kb
transcript ENSMUST00000163605 Ensembl | MGI Sequence Detail 4149 Not Applicable  
polypeptide ENSMUSP00000130440 Ensembl | MGI Sequence Detail 880 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    150 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029382 ATP-dependent DNA helicase DDX11
  • EC
  • InterPro Domains
    IPR006555 ATP-dependent helicase, C-terminal
    IPR010614 DEAD2
    IPR013020 DNA helicase (DNA repair), Rad3 type
    IPR006554 Helicase-like, DEXD box c2 type
    IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 30
    cDNA 29
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:3578202
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:185600 Cota CD, et al., The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Dev Dyn. 2012 Aug;241(8):1249-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory