Fermt1
Gene Detail

Symbol Name ID

Fermt1 fermitin family homolog 1 (Drosophila) MGI:2443583

Synonyms

5830467P10Rik, Kindlin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

64.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:132904389-132945906 bp, - strand From VEGA annotation of GRCm38   41518 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fermt1

Human homologs

Human Homolog		FERMT1, fermitin family member 1
NCBI Gene ID		55612
neXtProt AC		NX_Q9BQL6
Human Synonyms		C20orf42, DTGCU2, KIND1, UNC112A, URP1
Human Chr (Location)		20p12.3; chr20:6055492-6104191 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FERMT1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a null allele exhibit postnatal lethality within 5 days of birth, dehydration, detachment of colonic epithelial cells, and colonic inflammation.

 
Human Diseases Modeled Using Mouse Fermt1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell adhesion, establishment of epithelial cell polarity, ...
Component	cell junction, cell projection, ...
Function	phospholipid binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (51)    Images (21)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	75
Northern blot	14
RT-PCR	29

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000015663 (Evidence)
Ensembl Gene Model	ENSMUSG00000027356 (Evidence)
Entrez Gene	241639 (Evidence)
UniGene	209784
DFCI	TC1587652, TC1602995, TC1607419
DoTS	DT.55196580, DT.91580944, DT.97390231
NIA Mouse Gene Index	U023400
PDB	2KMC
Consensus CDS Project	CCDS38248.1
International Mouse Knockout Project Status	Fermt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015663	VEGA Gene Model | MGI Sequence Detail	41518	C57BL/6J
transcript	OTTMUST00000037213	VEGA | MGI Sequence Detail	4915	Not Applicable
polypeptide	OTTMUSP00000016676	VEGA | MGI Sequence Detail	677	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(293 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR014352	FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro	IPR019748	FERM central domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000031215	fermitin family homolog 1

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(26)