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Fermt1
Gene Detail
Symbol

Name
ID
Fermt1
fermitin family homolog 1 (Drosophila)
MGI:2443583
Synonyms
5830467P10Rik, Kindlin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
64.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:132904389-132945906 bp, - strand
From VEGA annotation of GRCm38

  41518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FERMT1
Gene Tree: Fermt1

Human
homologs
FERMT1, fermitin family member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55612
neXtProt AC: NX_Q9BQL6

Human Synonyms: C20orf42, DTGCU2, KIND1, UNC112A, URP1

Human Chr (Location): 20p12.3; chr20:6074845-6123544 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FERMT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality within 5 days of birth, dehydration, detachment of colonic epithelial cells, and colonic inflammation.
 
Human Diseases Modeled in Mice Using Fermt1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fermt1 interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, establishment of epithelial cell polarity, ...
Component cell junction, cell projection, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (51)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
Northern blot 14
RT-PCR 29
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fermt1 ; ZFIN fermt1    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000015663 (Evidence)
Ensembl Gene Model ENSMUSG00000027356 (Evidence)
Entrez Gene 241639 (Evidence)
UniGene 209784
DFCI TC1602995, TC1587652, TC1607419
DoTS DT.97390231, DT.91580944, DT.55196580
NIA Mouse Gene Index U023400
PDB 4BBK, 2KMC
Consensus CDS Project CCDS38248.1
International Mouse Phenotyping Consortium Status Fermt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015663 VEGA Gene Model | MGI Sequence Detail 41518 C57BL/6J ±  kb
transcript OTTMUST00000037213 VEGA | MGI Sequence Detail 4915 Not Applicable 
polypeptide OTTMUSP00000016676 VEGA | MGI Sequence Detail 677 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(364 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000031215 fermitin family homolog 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:210448 Rognoni E, et al., Kindlin-1 controls Wnt and TGF-beta availability to regulate cutaneous stem cell proliferation. Nat Med. 2014 Apr;20(4):350-9
All references(27)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory