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Fermt1
Gene Detail
 Symbol
Name
ID
Fermt1
fermitin family homolog 1 (Drosophila)
MGI:2443583
Synonyms 5830467P10Rik, Kindlin-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
64.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:132904389-132945906 bp, - strand
From VEGA annotation of GRCm38

  41518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fermt1

Human
homologs
Human Homolog FERMT1, fermitin family member 1
NCBI Gene ID 55612
neXtProt AC  NX_Q9BQL6
Human Synonyms  C20orf42, DTGCU2, KIND1, UNC112A, URP1
Human Chr (Location)  20p12.3; chr20:6074845-6123544 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FERMT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality within 5 days of birth, dehydration, detachment of colonic epithelial cells, and colonic inflammation.
 
Human Diseases Modeled Using Mouse Fermt1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Fermt1 interacts with 281 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, establishment of epithelial cell polarity, ...
Component cell junction, cell projection, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (51)    Images (21)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 75
Northern blot 14
RT-PCR 29
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000015663 (Evidence)
Ensembl Gene ModelENSMUSG00000027356 (Evidence)
Entrez Gene241639 (Evidence)
UniGene209784
DFCITC1587652, TC1602995, TC1607419
DoTSDT.55196580, DT.91580944, DT.97390231
NIA Mouse Gene IndexU023400
PDB2KMC, 4BBK
Consensus CDS ProjectCCDS38248.1
International Mouse Knockout Project StatusFermt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015663 VEGA Gene Model | MGI Sequence Detail 41518 C57BL/6J ±  kb
transcript OTTMUST00000037213 VEGA | MGI Sequence Detail 4915 Not Applicable 
polypeptide OTTMUSP00000016676 VEGA | MGI Sequence Detail 677 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(364 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000031215 fermitin family homolog 1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:207237 Brahme NN, et al., Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. J Biol Chem. 2013 Dec 6;288(49):35604-16
All references(27)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory