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Abat
Gene Detail
 Symbol
Name
ID
Abat
4-aminobutyrate aminotransferase
MGI:2443582
Synonyms 9630038C02Rik, GABA-T
Feature Type protein coding gene
Genetic Map
Chromosome 16
4.06 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:8513429-8621568 bp, + strand
From VEGA annotation of GRCm38

  108140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Transaminase_4ab_Lys_Orn
Gene Tree: Abat

Human
homologs
Human Homolog ABAT, 4-aminobutyrate aminotransferase
NCBI Gene ID 18
neXtProt AC  NX_P80404
Human Synonyms  GABA-AT, GABAT, NPD009
Human Chr (Location)  16p13.2; chr16:8674587-8784575 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ABAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(68) Targeted(3)
Incidental mutations (data from APF )
Interactions
Abat interacts with 277 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process behavioral response to cocaine, copulation, ...
Component 4-aminobutyrate transaminase complex, extracellular vesicular exosome, ...
Function 4-aminobutyrate transaminase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (341)    Tissues (115)    Images (42)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 341
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) cDNA(122) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025937 (Evidence)
Ensembl Gene ModelENSMUSG00000057880 (Evidence)
Entrez Gene268860 (Evidence)
UniGene259315
DFCITC1577881, TC1590610, TC1600266, TC1601472
DoTSDT.101310557, DT.101356611, DT.101738817, DT.103568298, DT.97334888
NIA Mouse Gene IndexU043491
EC2.6.1.19, 2.6.1.22
Consensus CDS ProjectCCDS27939.1, CCDS49754.1
International Mouse Knockout Project StatusAbat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025937 VEGA Gene Model | MGI Sequence Detail 108140 C57BL/6J ±  kb
transcript OTTMUST00000063947 VEGA | MGI Sequence Detail 4636 Not Applicable 
polypeptide OTTMUSP00000031702 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004631 4-aminobutyrate aminotransferase, eukaryotic
InterPro IPR005814 Aminotransferase class-III
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000003536 4-aminobutyrate aminotransferase, mitochondrial
References (Earliest) J:115381 Abel MS, et al., GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice. Metab Brain Dis. 1999 Dec;14(4):253-63
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(45)
Other
accession IDs
MGI:1930903, MGI:2146392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory