Abat
Gene Detail

Symbol Name ID

Abat 4-aminobutyrate aminotransferase MGI:2443582

Synonyms

9630038C02Rik, GABA-T

Feature Type

protein coding gene

Genetic Map

Chromosome 16

4.06 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:8513429-8621568 bp, + strand From VEGA annotation of GRCm38   108140 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 4-aminobutyrate/lysine/ornithine transaminase
Gene Tree: Abat

Human homologs

Human Homolog		ABAT, 4-aminobutyrate aminotransferase
NCBI Gene ID		18
neXtProt AC		NX_P80404
Human Synonyms		GABA-AT, GABAT, NPD009
Human Chr (Location)		16p13.2; chr16:8768444-8878432 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ABAT

Alleles and phenotypes

All alleles(71) : Targeted(3) Gene trapped(68)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	behavioral response to cocaine, copulation, ...
Component	4-aminobutyrate transaminase complex, mitochondrion, ...
Function	4-aminobutyrate transaminase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (341)    Tissues (115)    Images (42)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	341

cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(125) cDNA(124) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000025937 (Evidence)
Ensembl Gene Model	ENSMUSG00000057880 (Evidence)
Entrez Gene	268860 (Evidence)
UniGene	259315
DFCI	TC1577881, TC1590610, TC1600266, TC1601472
DoTS	DT.101310557, DT.101356611, DT.101738817, DT.103568298, DT.97334888
NIA Mouse Gene Index	U043491
EC	2.6.1.19, 2.6.1.22
Consensus CDS Project	CCDS27939.1, CCDS49754.1
International Mouse Knockout Project Status	Abat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025937	VEGA Gene Model | MGI Sequence Detail	108140	C57BL/6J
transcript	OTTMUST00000063947	VEGA | MGI Sequence Detail	4636	Not Applicable
polypeptide	OTTMUSP00000031702	VEGA | MGI Sequence Detail	500	Not Applicable

All sequences(62) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(318 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004631	4-aminobutyrate aminotransferase, eukaryotic
InterPro	IPR005814	Aminotransferase class-III
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology	PR:000003536	4-aminobutyrate aminotransferase, mitochondrial

References

(Earliest) J:115381 Abel MS, et al., GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice. Metab Brain Dis. 1999 Dec;14(4):253-63
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)

Other accession IDs

MGI:1930903, MGI:2146392