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Abat
Gene Detail
Symbol

Name
ID
Abat
4-aminobutyrate aminotransferase
MGI:2443582
Synonyms
9630038C02Rik, GABA-T
Feature Type
protein coding gene
Genetic Map
Chromosome 16
4.06 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:8513429-8621568 bp, + strand
From VEGA annotation of GRCm38

  108140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABAT
Protein SuperFamily: Transaminase_4ab_Lys_Orn
Gene Tree: Abat

Human
homologs
ABAT, 4-aminobutyrate aminotransferase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 18
neXtProt AC: NX_P80404

Human Synonyms: GABA-AT, GABAT, NPD009

Human Chr (Location): 16p13.2; chr16:8674587-8784575 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ABAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(68) Targeted(3)
Incidental mutations (data from APF )
Interactions
Abat interacts with 277 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process behavioral response to cocaine, copulation, ...
Component 4-aminobutyrate transaminase complex, extracellular exosome, ...
Function 4-aminobutyrate transaminase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (341)    Tissues (115)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 341
cDNA source data(122)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abat ; ZFIN abat    NEW 
Molecular
reagents
All nucleic(123) cDNA(122) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025937 (Evidence)
Ensembl Gene Model ENSMUSG00000057880 (Evidence)
Entrez Gene 268860 (Evidence)
UniGene 259315
DFCI TC1600266, TC1577881, TC1590610, TC1601472
DoTS DT.97334888, DT.103568298, DT.101738817, DT.101310557, DT.101356611
NIA Mouse Gene Index U043491
EC 2.6.1.22, 2.6.1.19
Consensus CDS Project CCDS27939.1, CCDS49754.1
International Mouse Phenotyping Consortium Status Abat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025937 VEGA Gene Model | MGI Sequence Detail 108140 C57BL/6J ±  kb
transcript OTTMUST00000063947 VEGA | MGI Sequence Detail 4636 Not Applicable 
polypeptide OTTMUSP00000031702 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004631 4-aminobutyrate aminotransferase, eukaryotic
InterPro IPR005814 Aminotransferase class-III
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000003536 4-aminobutyrate aminotransferase, mitochondrial
References
(Earliest) J:115381 Abel MS, et al., GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice. Metab Brain Dis. 1999 Dec;14(4):253-63
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(43)
Other
accession IDs
MGI:1930903, MGI:2146392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory