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Setx
Gene Detail
Symbol

Name
ID
Setx
senataxin
MGI:2443480
Synonyms
A930037J23Rik, Als4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:29124181-29182471 bp, + strand
From VEGA annotation of GRCm38

  58291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41003  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Setx

Human
homologs
Human Homolog SETX, senataxin
NCBI Gene ID 23064
neXtProt AC  NX_Q7Z333
Human Synonyms  ALS4, AOA2, bA479K20.2, SCAR1
Human Chr (Location)  9q34.13; chr9:132261440-132356726 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SETX
Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(58) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit increased IgM IgD expressing B cells.
 
Interactions
Setx interacts with 349 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular response to DNA damage stimulus, cellular response to fibroblast growth factor stimulus, ...
Component axon, cytoplasm, ...
Function ATP binding, helicase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011825 (Evidence)
Ensembl Gene ModelENSMUSG00000043535 (Evidence)
Entrez Gene269254 (Evidence)
DFCITC1630654, TC1586776, TC1602401, TC1574546
DoTSDT.94197853, DT.97410099, DT.91434680, DT.101736871, DT.101378888
NIA Mouse Gene IndexU001556
EC3.6.4.-
Consensus CDS ProjectCCDS38090.1
International Mouse Knockout Project StatusSetx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011825 VEGA Gene Model | MGI Sequence Detail 58291 C57BL/6J ±  kb
transcript OTTMUST00000027763 VEGA | MGI Sequence Detail 10970 Not Applicable 
polypeptide OTTMUSP00000012614 VEGA | MGI Sequence Detail 2646 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR026121 Probable helicase senataxin
Protein Ontology PR:000031605 helicase senataxin
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
All references(37)
Other
accession IDs
MGI:2139292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory