Setx
Gene Detail

Symbol

Name
ID

Setx
senataxin
MGI:2443480

Synonyms

A930037J23Rik, Als4

Feature Type

protein coding gene

Genetic Map

Chromosome 2
19.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:29124181-29182471 bp, + strand From VEGA annotation of GRCm38   58291 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41003  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Setx

Human
homologs

Human Homolog		SETX, senataxin
NCBI Gene ID		23064
neXtProt AC		NX_Q7Z333
Human Synonyms		ALS4, AOA2, bA479K20.2, SCAR1
Human Chr (Location)		9q34.13; chr9:132261440-132356726 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human SETX

Mutations,
alleles, and
phenotypes

All mutations/alleles(60) : Gene trapped(58) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for an ENU-induced allele exhibit increased IgM IgD expressing B cells.

 

Interactions

Setx interacts with 349 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (33 annotations)

Process	cellular response to DNA damage stimulus, cellular response to fibroblast growth factor stimulus, ...
Component	axon, cytoplasm, ...
Function	ATP binding, helicase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(9) cDNA(9)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000011825 (Evidence)
Ensembl Gene Model	ENSMUSG00000043535 (Evidence)
Entrez Gene	269254 (Evidence)
DFCI	TC1574546, TC1586776, TC1602401, TC1630654
DoTS	DT.101736871, DT.97410099, DT.101378888, DT.94197853, DT.91434680
NIA Mouse Gene Index	U001556
EC	3.6.4.-
Consensus CDS Project	CCDS38090.1
International Mouse Knockout Project Status	Setx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011825	VEGA Gene Model | MGI Sequence Detail	58291	C57BL/6J
transcript	OTTMUST00000027763	VEGA | MGI Sequence Detail	10970	Not Applicable
polypeptide	OTTMUSP00000012614	VEGA | MGI Sequence Detail	2646	Not Applicable

All sequences(63) RefSeq(16) UniProt(3)

Polymorphisms

SNPs within 2kb(165 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR026121	Probable helicase senataxin
Protein Ontology	PR:000031605	helicase senataxin

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:215106 Yeo AJ, et al., R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias. PLoS One. 2014;9(3):e90219
All references(38)

Other
accession IDs

MGI:2139292