Setx
Gene Detail

Symbol Name ID

Setx senataxin MGI:2443480

Synonyms

A930037J23Rik, Als4

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:29124181-29182471 bp, + strand From VEGA annotation of GRCm38   58291 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41003  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Setx

Human homologs

Human Homolog		SETX, senataxin
NCBI Gene ID		23064
neXtProt AC		NX_Q7Z333
Human Synonyms		ALS4, AOA2, bA479K20.2, SCAR1
Human Chr (Location)		9q34.13; chr9:132261440-132356726 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human SETX

Alleles and phenotypes

All alleles(60) : Chemically induced (ENU)(1) Gene trapped(58) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for an ENU-induced allele exhibit increased IgM IgD expressing B cells.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cellular response to DNA damage stimulus, circadian rhythm, ...
Component	cytoplasm, nucleoplasm, ...
Function	ATP binding, helicase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011825 (Evidence)
Ensembl Gene Model	ENSMUSG00000043535 (Evidence)
Entrez Gene	269254 (Evidence)
DFCI	TC1574546, TC1586776, TC1602401, TC1630654
DoTS	DT.101378888, DT.101736871, DT.91434680, DT.94197853, DT.97410099
NIA Mouse Gene Index	U001556
EC	3.6.4.-
Consensus CDS Project	CCDS38090.1
International Mouse Knockout Project Status	Setx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011825	VEGA Gene Model | MGI Sequence Detail	58291	C57BL/6J
transcript	OTTMUST00000027763	VEGA | MGI Sequence Detail	10970	Not Applicable
polypeptide	OTTMUSP00000012614	VEGA | MGI Sequence Detail	2646	Not Applicable

All sequences(60) RefSeq(14) UniProt(2)

Polymorphisms

SNPs within 2kb(165 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR026121	Probable helicase senataxin
Protein Ontology	PR:000031605	probable helicase senataxin

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
All references(36)

Other accession IDs

MGI:2139292