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Dse Gene Detail
Summary
  • Symbol
    Dse
  • Name
    dermatan sulfate epimerase
  • Synonyms
    B130024B19Rik, DS-epi1, Sart2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443455
    NCBI Gene: 212898
  • Gene Overview
    MyGene.info: DSE
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:34151393-34207715 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 18.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    510 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443455
protein coding gene Chr10:34151386-34208277 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017137
protein coding gene Chr10:32489675-32547702 (-)
A/J MGP_AJ_G0017114
protein coding gene Chr10:31637964-31698610 (-)
AKR/J MGP_AKRJ_G0017074
protein coding gene Chr10:32007079-32064405 (-)
BALB/cJ MGP_BALBcJ_G0017077
protein coding gene Chr10:31585627-31642194 (-)
C3H/HeJ MGP_C3HHeJ_G0016897
protein coding gene Chr10:32305051-32362355 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017535
protein coding gene Chr10:33417773-33475069 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015232
protein coding gene Chr10:29977922-30033027 (-)
CAST/EiJ MGP_CASTEiJ_G0016476
protein coding gene Chr10:32429298-32492201 (-)
CBA/J MGP_CBAJ_G0016871
protein coding gene Chr10:35035391-35091815 (-)
DBA/2J MGP_DBA2J_G0016976
protein coding gene Chr10:31218209-31274626 (-)
FVB/NJ MGP_FVBNJ_G0016971
protein coding gene Chr10:30722545-30779101 (-)
LP/J MGP_LPJ_G0017053
protein coding gene Chr10:32482734-32540827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017001
protein coding gene Chr10:35518906-35580114 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017571
protein coding gene Chr10:31959920-32018143 (-)
PWK/PhJ MGP_PWKPhJ_G0016257
protein coding gene Chr10:30979642-31037686 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016041
protein coding gene Chr10:31837306-31897502 (-)
WSB/EiJ MGP_WSBEiJ_G0016539
protein coding gene Chr10:32169392-32232486 (-)



Homology
more
  • Human Ortholog
    DSE, dermatan sulfate epimerase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DSE, dermatan sulfate epimerase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DSEP, DSEPI, DS-epi1, EDSMC2, SART2, SART-2
  • Links
    NCBI Gene ID: 29940
    neXtProt AC: NX_Q9UL01
    UniProt: Q9UL01

  • Chr Location
    6q22.1; chr6:116254152-116441261 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight and length with altered skin morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039497 Ensembl Gene Model | MGI Sequence Detail 56323 C57BL/6J ±  kb
transcript ENSMUST00000048010 Ensembl | MGI Sequence Detail 4389 Not Applicable  
polypeptide ENSMUSP00000040074 Ensembl | MGI Sequence Detail 958 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143625
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:244896 Stachtea XN, et al., Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. PLoS One. 2015;10(10):e0140279

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory