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Dse
Gene Detail
Symbol

Name
ID
Dse
dermatan sulfate epimerase
MGI:2443455
Synonyms
B130024B19Rik, DS-epi1, Sart2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
18.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:34151394-34207551 bp, - strand
From Ensembl annotation of GRCm38

  56158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: DSE
Protein SuperFamily: chondroitin-glucuronate C5-epimerase
Gene Tree: Dse

Human
homologs
DSE, dermatan sulfate epimerase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29940
neXtProt AC: NX_Q9UL01

Human Synonyms: DSEP, DSEPI, EDSMC2, SART2, SART-2

Human Chr (Location): 6q22; chr6:116280120-116443475 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DSE

Mutations,
alleles, and
phenotypes
All mutations/alleles(121) : Gene trapped(118) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased body weight and length with altered skin morphology and physiology.
 
Interactions
Dse interacts with 173 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process dermatan sulfate biosynthetic process
Component endoplasmic reticulum, Golgi apparatus, ...
Function chondroitin-glucuronate 5-epimerase activity, isomerase activity
External Resources: FuncBase
Expression
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dse ; ZFIN dse    NEW 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039497 (Evidence)
Entrez Gene 212898 (Evidence)
UniGene 34557
DFCI TC1576024
DoTS DT.485708
NIA Mouse Gene Index U031682
EC 5.1.3.19
Consensus CDS Project CCDS23776.1
International Mouse Phenotyping Consortium Status Dse
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039497 Ensembl Gene Model | MGI Sequence Detail 56158 C57BL/6J ±  kb
transcript ENSMUST00000048010 Ensembl | MGI Sequence Detail 4224 Not Applicable 
polypeptide ENSMUSP00000040074 Ensembl | MGI Sequence Detail 958 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(510 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008929 Chondroitin AC/alginate lyase
Protein Ontology PR:000006704 dermatan-sulfate epimerase
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:213094 Thelin MA, et al., Biological functions of iduronic acid in chondroitin/dermatan sulfate. FEBS J. 2013 May;280(10):2431-46
All references(31)
Other
accession IDs
MGI:2143625

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory