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Dse Gene Detail
Summary
  • Symbol
    Dse
  • Name
    dermatan sulfate epimerase
  • Synonyms
    B130024B19Rik, DS-epi1, Sart2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443455
    NCBI Gene: 212898
  • Gene Overview
    MyGene.info: DSE
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:34151393-34207715 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56323 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 18.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DSE, dermatan sulfate epimerase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DSE, dermatan sulfate epimerase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DSEP, DSEPI, DS-epi1, EDSMC2, SART2, SART-2
  • Links
    NCBI Gene ID: 29940
    neXtProt AC: NX_Q9UL01
    UniProt: Q9UL01

  • Chr Location
    6q22.1; chr6:116254152-116441261 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight and length with altered skin morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039497 Ensembl Gene Model | MGI Sequence Detail 56323 C57BL/6J ±  kb
transcript ENSMUST00000048010 Ensembl | MGI Sequence Detail 4389 Not Applicable  
polypeptide ENSMUSP00000040074 Ensembl | MGI Sequence Detail 958 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    510 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143625
References
more
  • Summaries
    All 36
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:244896 Stachtea XN, et al., Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. PLoS One. 2015;10(10):e0140279

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory