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Arhgap22 Gene Detail
Summary
  • Symbol
    Arhgap22
  • Name
    Rho GTPase activating protein 22
  • Synonyms
    B230341L19Rik, RHOGAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443418
    NCBI Gene: 239027
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33214026-33369934 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1394 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443418
protein coding gene Chr14:33214004-33369936 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021155
protein coding gene Chr14:26511967-26670792 (+)
A/J MGP_AJ_G0021103
protein coding gene Chr14:25494601-25649758 (+)
AKR/J MGP_AKRJ_G0021080
protein coding gene Chr14:26639303-26793277 (+)
BALB/cJ MGP_BALBcJ_G0021107
protein coding gene Chr14:25664112-25817268 (+)
C3H/HeJ MGP_C3HHeJ_G0020890
protein coding gene Chr14:26540277-26702602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021539
protein coding gene Chr14:27531396-27723552 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019101
protein coding gene Chr14:25532192-25686200 (+)
CAST/EiJ MGP_CASTEiJ_G0020415
protein coding gene Chr14:26356881-26674568 (+)
CBA/J MGP_CBAJ_G0020857
protein coding gene Chr14:28584691-28749999 (+)
DBA/2J MGP_DBA2J_G0020979
protein coding gene Chr14:25534696-25687143 (+)
FVB/NJ MGP_FVBNJ_G0020963
protein coding gene Chr14:25479229-25637523 (+)
LP/J MGP_LPJ_G0021048
protein coding gene Chr14:26829380-26987667 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020989
protein coding gene Chr14:27749215-27911924 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021572
protein coding gene Chr14:26455252-26616887 (+)
PWK/PhJ MGP_PWKPhJ_G0020163
protein coding gene Chr14:25000152-25156640 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019987
protein coding gene Chr14:26095407-26251964 (+)
WSB/EiJ MGP_WSBEiJ_G0020470
protein coding gene Chr14:26526929-26683966 (+)



Homology
more
  • Human Ortholog
    ARHGAP22, Rho GTPase activating protein 22
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGAP22, Rho GTPase activating protein 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RhoGAP2, RhoGap22
  • Links
    NCBI Gene ID: 58504
    neXtProt AC: NX_Q7Z5H3
    UniProt: Q7Z5H3

  • Chr Location
    10q11.22-q11.23; chr10:48429831-48656265 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063506 Ensembl Gene Model | MGI Sequence Detail 155909 C57BL/6J ±  kb
transcript ENSMUST00000111956 Ensembl | MGI Sequence Detail 2596 Not Applicable  
polypeptide ENSMUSP00000107587 Ensembl | MGI Sequence Detail 702 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:224836 Hoch RV, et al., OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21;12(3):482-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory