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Tmem74 Gene Detail
Summary
  • Symbol
    Tmem74
  • Name
    transmembrane protein 74
  • Synonyms
    B230382K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443417
    NCBI Gene: 239408
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43866695-43870614 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443417
protein coding gene Chr15:43864646-43870614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021827
protein coding gene Chr15:42463320-42466632 (-)
A/J MGP_AJ_G0021787
protein coding gene Chr15:40847711-40851081 (-)
AKR/J MGP_AKRJ_G0021768
protein coding gene Chr15:42041790-42045484 (-)
BALB/cJ MGP_BALBcJ_G0021794
protein coding gene Chr15:40929901-40933235 (-)
C3H/HeJ MGP_C3HHeJ_G0021568
protein coding gene Chr15:41957993-41961325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022233
protein coding gene Chr15:44107261-44110753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019770
protein coding gene Chr15:38402721-38406023 (-)
CAST/EiJ MGP_CASTEiJ_G0021085
protein coding gene Chr15:42488906-42492250 (-)
CBA/J MGP_CBAJ_G0021537
protein coding gene Chr15:45639064-45642404 (-)
DBA/2J MGP_DBA2J_G0021661
protein coding gene Chr15:40659882-40663212 (-)
FVB/NJ MGP_FVBNJ_G0021639
protein coding gene Chr15:39965310-39968662 (-)
LP/J MGP_LPJ_G0021731
protein coding gene Chr15:42239717-42243045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021663
protein coding gene Chr15:48988034-48991348 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022256
protein coding gene Chr15:42243932-42247262 (-)
PWK/PhJ MGP_PWKPhJ_G0020830
protein coding gene Chr15:40695459-40698841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020667
protein coding gene Chr15:41895520-41898840 (-)
WSB/EiJ MGP_WSBEiJ_G0021140
protein coding gene Chr15:42138909-42142231 (-)



Homology
more
  • Human Ortholog
    TMEM74, transmembrane protein 74
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM74, transmembrane protein 74
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NET36
  • Links
    NCBI Gene ID: 157753
    neXtProt AC: NX_Q96NL1
    UniProt: Q96NL1

  • Chr Location
    8q23.1; chr8:108606850-108787615 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17684
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TMEM74
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 239408 NCBI Gene Model | MGI Sequence Detail 3920 C57BL/6J ±  kb
transcript NM_175502 RefSeq | MGI Sequence Detail 1472 C57BL/6  
polypeptide Q8BQU7 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:3034807
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory