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Tmem74 Gene Detail
Summary
  • Symbol
    Tmem74
  • Name
    transmembrane protein 74
  • Synonyms
    B230382K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443417
    NCBI Gene: 239408
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43728042-43733432 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443417
protein coding gene Chr15:43726741-43733462 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021827
protein coding gene Chr15:42463320-42466632 (-)
A/J MGP_AJ_G0021787
protein coding gene Chr15:40847711-40851081 (-)
AKR/J MGP_AKRJ_G0021768
protein coding gene Chr15:42041790-42045484 (-)
BALB/cJ MGP_BALBcJ_G0021794
protein coding gene Chr15:40929901-40933235 (-)
C3H/HeJ MGP_C3HHeJ_G0021568
protein coding gene Chr15:41957993-41961325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022233
protein coding gene Chr15:44107261-44110753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019770
protein coding gene Chr15:38402721-38406023 (-)
CAST/EiJ MGP_CASTEiJ_G0021085
protein coding gene Chr15:42488906-42492250 (-)
CBA/J MGP_CBAJ_G0021537
protein coding gene Chr15:45639064-45642404 (-)
DBA/2J MGP_DBA2J_G0021661
protein coding gene Chr15:40659882-40663212 (-)
FVB/NJ MGP_FVBNJ_G0021639
protein coding gene Chr15:39965310-39968662 (-)
LP/J MGP_LPJ_G0021731
protein coding gene Chr15:42239717-42243045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021663
protein coding gene Chr15:48988034-48991348 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022256
protein coding gene Chr15:42243932-42247262 (-)
PWK/PhJ MGP_PWKPhJ_G0020830
protein coding gene Chr15:40695459-40698841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020667
protein coding gene Chr15:41895520-41898840 (-)
WSB/EiJ MGP_WSBEiJ_G0021140
protein coding gene Chr15:42138909-42142231 (-)



Homology
more
  • Human Ortholog
    TMEM74, transmembrane protein 74
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM74, transmembrane protein 74
  • Synonyms
    NET36
  • Links
    NCBI Gene ID: 157753
    neXtProt AC: NX_Q96NL1
    UniProt: Q96NL1

  • Chr Location
    8q23.1; chr8:108606850-108787594 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects basolateral amygdaloid nucleus (BLA) pyramidal neuron electrophysiology, leading to increased anxiety-like behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054409 Ensembl Gene Model | MGI Sequence Detail 5391 C57BL/6J ±  kb
    transcript ENSMUST00000067469 Ensembl | MGI Sequence Detail 3528 Not Applicable  
    polypeptide ENSMUSP00000070748 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3034807
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory