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Slc4a9 Gene Detail
Summary
  • Symbol
    Slc4a9
  • Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 9
  • Synonyms
    AE4, D630024F24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443384
    NCBI Gene: 240215
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36528147-36556273 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443384
protein coding gene Chr18:36528063-36556273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024279
protein coding gene Chr18:34926548-34939661 (+)
A/J MGP_AJ_G0024245
protein coding gene Chr18:33696794-33709925 (+)
AKR/J MGP_AKRJ_G0024213
protein coding gene Chr18:34639212-34653890 (+)
BALB/cJ MGP_BALBcJ_G0024245
protein coding gene Chr18:33747777-33760904 (+)
C3H/HeJ MGP_C3HHeJ_G0024012
protein coding gene Chr18:34705424-34718539 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024686
protein coding gene Chr18:36151956-36165060 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022126
protein coding gene Chr18:33792884-33809778 (+)
CAST/EiJ MGP_CASTEiJ_G0023487
protein coding gene Chr18:34708291-34739029 (+)
CBA/J MGP_CBAJ_G0023980
protein coding gene Chr18:37225802-37238931 (+)
DBA/2J MGP_DBA2J_G0024112
protein coding gene Chr18:33320929-33334040 (+)
FVB/NJ MGP_FVBNJ_G0024079
protein coding gene Chr18:33027173-33040299 (+)
LP/J MGP_LPJ_G0024194
protein coding gene Chr18:34950092-34965988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024107
protein coding gene Chr18:38439442-38452547 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024735
protein coding gene Chr18:34513389-34526486 (+)
PWK/PhJ MGP_PWKPhJ_G0023231
protein coding gene Chr18:33568265-33586081 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023038
protein coding gene Chr18:34761755-34774927 (+)
WSB/EiJ MGP_WSBEiJ_G0023550
protein coding gene Chr18:34432050-34450444 (+)



Homology
more
  • Human Ortholog
    SLC4A9, solute carrier family 4 member 9
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC4A9, solute carrier family 4 member 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AE4
  • Links
    NCBI Gene ID: 83697
    neXtProt AC: NX_Q96Q91
    UniProt: Q96Q91

  • Chr Location
    5q31.3; chr5:140359645-140375177 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered ion exchange in intestinal epithelia and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024485 Ensembl Gene Model | MGI Sequence Detail 28127 C57BL/6J ±  kb
transcript ENSMUST00000236124 Ensembl | MGI Sequence Detail 3152 Not Applicable  
polypeptide ENSMUSP00000157862 Ensembl | MGI Sequence Detail 952 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR013769 Band 3 cytoplasmic domain
    IPR011531 Bicarbonate transporter, C-terminal
    IPR003020 Bicarbonate transporter, eukaryotic
    IPR016152 Phosphotransferase/anion transporter
    IPR003024 Sodium bicarbonate cotransporter
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:249431 Honda K, et al., Molecular architecture underlying fluid absorption by the developing inner ear. Elife. 2017 Oct 10;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory