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Unc45b Gene Detail
Summary
  • Symbol
    Unc45b
  • Name
    unc-45 myosin chaperone B
  • Synonyms
    Cmya4, D230041A13Rik, UNC45
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443377
    NCBI Gene: 217012
Location & Maps
more
  • Sequence Map
    Chr11:82910550-82943403 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32854 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UNC45B, unc-45 myosin chaperone B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC45B, unc-45 myosin chaperone B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMYA4, CTRCT43, SMUNC45, UNC45, UNC-45B
  • Links
    NCBI Gene ID: 146862
    neXtProt AC: NX_Q8IWX7

  • Chr Location
    17q12; chr17:35147798-35189345 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human UNC45B associations

Human Disease Mouse Models
       Cataract 43; CTRCT43   OMIM: 616279
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    2 involving Unc45b
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E9 without placental abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000930 VEGA Gene Model | MGI Sequence Detail 32854 C57BL/6J ±  kb
transcript OTTMUST00000001814 VEGA | MGI Sequence Detail 4152 Not Applicable  
polypeptide OTTMUSP00000000874 VEGA | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    264 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 12
    cDNA 9
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGI:2671016
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:79580 Le Bras S, et al., Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome. Gene. 2002 Aug 21;296(1-2):75
  • Latest
    J:222450 Uribe V, et al., Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory