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Fa2h
Gene Detail
Symbol

Name
ID
Fa2h
fatty acid 2-hydroxylase
MGI:2443327
Synonyms
Faxdc1, G630055L08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:111345135-111393824 bp, - strand
From VEGA annotation of GRCm38

  48690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FA2H
Protein SuperFamily: inositolphosphorylceramide-B hydroxylase
Gene Tree: Fa2h

Human
homologs
FA2H, fatty acid 2-hydroxylase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 79152
neXtProt AC: NX_Q7L5A8

Human Synonyms: FAAH, FAH1, FAXDC1, SCS7, SPG35

Human Chr (Location): 16q23; chr16:74712955-74774831 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FA2H

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this marker experience late onset axon and myelin degeneration.
 
Human Diseases Modeled in Mice Using Fa2h (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fa2h interacts with 235 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FA2H ; Xenbase fa2h ; ZFIN fa2h    NEW 
Molecular
reagents
All nucleic(33) cDNA(33)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027478 (Evidence)
Ensembl Gene Model ENSMUSG00000033579 (Evidence)
Entrez Gene 338521 (Evidence)
UniGene 41083
DFCI TC1580906, TC1616840, TC1620257
DoTS DT.482229, DT.91290696, DT.101717793, DT.110860606
NIA Mouse Gene Index U030263
EC 1.-.-.-
Consensus CDS Project CCDS22674.1
International Mouse Phenotyping Consortium Status Fa2h
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027478 VEGA Gene Model | MGI Sequence Detail 48690 C57BL/6J ±  kb
transcript OTTMUST00000068006 VEGA | MGI Sequence Detail 2492 Not Applicable 
polypeptide OTTMUSP00000034302 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018506 Cytochrome b5, heme-binding site
InterPro IPR001199 Cytochrome b5-like heme/steroid binding domain
InterPro IPR006694 Fatty acid hydroxylase
InterPro IPR014430 Inositolphosphorylceramide-B hydroxylase
Protein Ontology PR:000007304 fatty acid 2-hydroxylase
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
All references(33)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory