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Map1s Gene Detail
Summary
  • Symbol
    Map1s
  • Name
    microtubule-associated protein 1S
  • Synonyms
    6430517J16Rik, Bpy2ip1, Map8, Mtap1s, VCY2IP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443304
    NCBI Gene: 270058
  • Gene Overview
    MyGene.info: MAP1S
Location & Maps
more
  • Sequence Map
    Chr8:70905974-70917526 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.41 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAP1S, microtubule associated protein 1S
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MAP1S, microtubule associated protein 1S
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPY2IP1, C19orf5, MAP8, VCY2IP1, VCY2IP-1
  • Links
    NCBI Gene ID: 55201
    neXtProt AC: NX_Q66K74

  • Chr Location
    19p13.11; chr19:17719494-17734515 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    3
  • Genomic Mutations
    1 involving Map1s
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit defective biogenesis and degradation of autophagosomes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019261 Ensembl Gene Model | MGI Sequence Detail 11553 C57BL/6J ±  kb
transcript ENSMUST00000019405 Ensembl | MGI Sequence Detail 3271 Not Applicable  
polypeptide ENSMUSP00000019405 Ensembl | MGI Sequence Detail 973 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    171 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010123 microtubule-associated protein 1S
  • InterPro Domains
    IPR001279 Metallo-beta-lactamase
    IPR026074 Microtubule associated protein 1
    IPR027322 Microtubule-associated protein 1S
Molecular
Reagents
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  • All nucleic 50
    Genomic 1
    cDNA 49

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:231330 Li W, et al., Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. Aging Cell. 2016 Apr;15(2):370-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory