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Zbtb7c Gene Detail
Summary
  • Symbol
    Zbtb7c
  • Name
    zinc finger and BTB domain containing 7C
  • Synonyms
    B230208J24Rik, Kr-pok, Zbtb36
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443302
    NCBI Gene: 207259
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:75820178-76148564 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 51.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4425 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443302
protein coding gene Chr18:75820178-76148564 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024566
protein coding gene Chr18:76539923-76890420 (+)
A/J MGP_AJ_G0024533
protein coding gene Chr18:73202079-73524318 (+)
AKR/J MGP_AKRJ_G0024504
protein coding gene Chr18:75377972-75699517 (+)
BALB/cJ MGP_BALBcJ_G0024533
protein coding gene Chr18:73402331-73734210 (+)
C3H/HeJ MGP_C3HHeJ_G0024301
protein coding gene Chr18:75487622-75830532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024979
protein coding gene Chr18:78548852-78898980 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022409
protein coding gene Chr18:72262795-72590683 (+)
CAST/EiJ MGP_CASTEiJ_G0023774
protein coding gene Chr18:76039490-76049802 (+)
CBA/J MGP_CBAJ_G0024270
protein coding gene Chr18:81265643-81630226 (+)
DBA/2J MGP_DBA2J_G0024400
protein coding gene Chr18:72784872-73115682 (+)
FVB/NJ MGP_FVBNJ_G0024366
protein coding gene Chr18:72138542-72469583 (+)
LP/J MGP_LPJ_G0024484
protein coding gene Chr18:76419751-76773994 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024396
protein coding gene Chr18:82638901-82990119 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025027
protein coding gene Chr18:75515917-75854067 (+)
PWK/PhJ MGP_PWKPhJ_G0023518
protein coding gene Chr18:73509260-73519748 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023322
protein coding gene Chr18:76009276-76024759 (+)
WSB/EiJ MGP_WSBEiJ_G0023837
protein coding gene Chr18:75461382-75800357 (+)



Homology
more
  • Human Ortholog
    ZBTB7C, zinc finger and BTB domain containing 7C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZBTB7C, zinc finger and BTB domain containing 7C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APM1, APM-1, ZBTB36, ZNF857C
  • Links
    NCBI Gene ID: 201501
    neXtProt AC: NX_A1YPR0
    UniProt: A1YPR0

  • Chr Location
    18q21.1; chr18:48026886-48412639 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17070
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZBTB7C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit decreased proliferation of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 207259 NCBI Gene Model | MGI Sequence Detail 328387 C57BL/6J ±  kb
transcript NM_145356 RefSeq | MGI Sequence Detail 4591 C57BL/6  
polypeptide Q8VCZ7 UniProt | EBI | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:251534 Jeon BN, et al., Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription. Biochim Biophys Acta. 2016 Nov;1859(11):1429-1439

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory