About   Help   FAQ
Slc2a6 Gene Detail
Summary
  • Symbol
    Slc2a6
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 6
  • Synonyms
    F630103L12Rik, Glut6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443286
    NCBI Gene: 227659
  • Gene Overview
    MyGene.info: SLC2A6
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27021363-27027998 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443286
protein coding gene Chr2:27021363-27027998 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025507
protein coding gene Chr2:24992211-24998846 (-)
A/J MGP_AJ_G0025484
protein coding gene Chr2:24045579-24052214 (-)
AKR/J MGP_AKRJ_G0025454
protein coding gene Chr2:24838546-24845181 (-)
BALB/cJ MGP_BALBcJ_G0025480
protein coding gene Chr2:24165496-24172131 (-)
C3H/HeJ MGP_C3HHeJ_G0025241
protein coding gene Chr2:24773160-24781427 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025924
protein coding gene Chr2:25841969-25848604 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023335
protein coding gene Chr2:22880797-22887417 (-)
CAST/EiJ MGP_CASTEiJ_G0024704
protein coding gene Chr2:24648549-24655190 (-)
CBA/J MGP_CBAJ_G0025219
protein coding gene Chr2:26735817-26742452 (-)
DBA/2J MGP_DBA2J_G0025352
protein coding gene Chr2:23865253-23871888 (-)
FVB/NJ MGP_FVBNJ_G0025314
protein coding gene Chr2:23622063-23628692 (-)
LP/J MGP_LPJ_G0025438
protein coding gene Chr2:24937599-24944234 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025345
protein coding gene Chr2:26784752-26791387 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025983
protein coding gene Chr2:24775701-24782336 (-)
PWK/PhJ MGP_PWKPhJ_G0024452
protein coding gene Chr2:23656687-23663336 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024252
protein coding gene Chr2:24920488-24927129 (-)
WSB/EiJ MGP_WSBEiJ_G0024773
protein coding gene Chr2:24889408-24896043 (-)



Homology
more
  • Human Ortholog
    SLC2A6, solute carrier family 2 member 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC2A6, solute carrier family 2 member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUT6, GLUT9, HSA011372
  • Links
    NCBI Gene ID: 11182
    neXtProt AC: NX_Q9UGQ3
    UniProt: Q9UGQ3

  • Chr Location
    9q34.2; chr9:133471094-133479154 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null females fed a Western diet exhibit decreased adiposity and females fed a chow diet, but not Western diet, show lower respiratory exchange ratio.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227659 NCBI Gene Model | MGI Sequence Detail 6636 C57BL/6J ±  kb
    transcript NM_172659 RefSeq | MGI Sequence Detail 2136 C57BL/6  
    polypeptide Q3UDF0 UniProt | EBI | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:4901 Fan YS, et al., Assignment of genes encoding three human glucose transporter/transporter-like proteins (GLUT4, GLUT5 and GLUT6) to chromosomes 17, 1 and 5 respectively. Cytogenet Cell Genet. 1989;51:997
    • Latest
      J:270487 Maedera S, et al., GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages. FEBS Lett. 2019 Jan;593(2):195-208

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory