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Tnni3k Gene Detail
Summary
  • Symbol
    Tnni3k
  • Name
    TNNI3 interacting kinase
  • Synonyms
    Cark, D830019J24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443276
    NCBI Gene: 435766
  • Gene Overview
    MyGene.info: TNNI3K
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:154786291-155055407 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 79.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1771 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443276
protein coding gene Chr3:154786291-155055407 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028006
protein coding gene Chr3:158814352-159086482 (-)
A/J MGP_AJ_G0027965
protein coding gene Chr3:153011613-153291433 (-)
AKR/J MGP_AKRJ_G0027931
protein coding gene Chr3:157104662-157385039 (-)
BALB/cJ MGP_BALBcJ_G0027977
protein coding gene Chr3:152820924-153091304 (-)
C3H/HeJ MGP_C3HHeJ_G0027707
protein coding gene Chr3:157471553-157755838 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028420
protein coding gene Chr3:163982521-164268488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025758
protein coding gene Chr3:147764950-148024603 (-)
CAST/EiJ MGP_CASTEiJ_G0027160
protein coding gene Chr3:157605864-157888830 (-)
CBA/J MGP_CBAJ_G0027682
protein coding gene Chr3:169885770-170173029 (-)
DBA/2J MGP_DBA2J_G0027822
protein coding gene Chr3:152083549-152352304 (-)
FVB/NJ MGP_FVBNJ_G0027789
protein coding gene Chr3:149459913-149727466 (-)
LP/J MGP_LPJ_G0027933
protein coding gene Chr3:160132472-160410220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027822
protein coding gene Chr3:178316012-178596458 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028479
protein coding gene Chr3:156747786-157024558 (-)
PWK/PhJ MGP_PWKPhJ_G0026883
protein coding gene Chr3:152018428-152290721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026711
protein coding gene Chr3:154918544-155213188 (-)
WSB/EiJ MGP_WSBEiJ_G0027240
protein coding gene Chr3:157738421-158007085 (-)



Homology
more
  • Human Ortholog
    TNNI3K, TNNI3 interacting kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNNI3K, TNNI3 interacting kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CARK, CCDD
  • Links
    NCBI Gene ID: 51086
    neXtProt AC: NX_Q59H18
    UniProt: Q59H18

  • Chr Location
    1p31.1; chr1:74235387-74544432 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in cardiac myocytes exhibit decreased response to cardiac ischemic/reperfusion injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 435766 NCBI Gene Model | MGI Sequence Detail 269117 C57BL/6J ±  kb
transcript NM_177066 RefSeq | MGI Sequence Detail 3042 C57BL/6  
polypeptide Q5GIG6 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:249318 Patterson M, et al., Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep;49(9):1346-1353

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory