Agfg2 MGI Mouse Gene Detail - MGI:2443267

Symbol

Agfg2
Name

ArfGAP with FG repeats 2
Synonyms

A630095P14Rik, Hrbl, MGC:61203, MGC:7148

Feature Type

protein coding gene
IDs

MGI:2443267
NCBI Gene: 231801
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:137648725-137682988 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 76.59 cM
Mapping Data

1 experiment

SNPs within 2kb

1092 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443267	protein coding gene	Chr5:137648725-137683068 (-)
129S1/SvImJ	ENSMUSG00200044343	protein coding gene	Chr5:131444334-131479748 (-)
A/J	ENSMUSG00195047521	protein coding gene	Chr5:130946926-130981204 (-)
AKR/J	ENSMUSG00220045545	protein coding gene	Chr5:130422198-130457638 (-)
BALB/cJ	ENSMUSG00180041011	protein coding gene	Chr5:131043489-131077760 (-)
C3H/HeJ	ENSMUSG00175047642	protein coding gene	Chr5:132971003-133005275 (-)
C57BL/6NJ	ENSMUSG00215045195	protein coding gene	Chr5:131092338-131126615 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027888	protein coding gene	Chr5:130459504-130493567 (-)
CAST/EiJ	ENSTCUG00005009790	protein coding gene	Chr5:130314642-130349655 (-)
CBA/J	ENSMUSG00210023338	protein coding gene	Chr5:131788569-131822844 (-)
DBA/2J	ENSMUSG00185053455	protein coding gene	Chr5:134803936-134838202 (-)
FVB/NJ	ENSMUSG00205048481	protein coding gene	Chr5:130687681-130721962 (-)
JF1/MsJ	ENSUMUG00000046311	protein coding gene	Chr5:137699510-137735296 (-)
LP/J	ENSMUSG00230042579	protein coding gene	Chr5:138917401-138951667 (-)
NOD/ShiLtJ	ENSMUSG00190036281	protein coding gene	Chr5:130743224-130777482 (-)
NZO/HlLtJ	ENSMUSG00225023586	protein coding gene	Chr5:146592321-146627720 (-)
PWK/PhJ	ENSLUMG00010017646	protein coding gene	Chr5:129552995-129589265 (-)
SPRET/EiJ	ENSMSPG00010035947	protein coding gene	Chr5:132951898-132985538 (-)
WSB/EiJ	ENSIUOG00005035848	protein coding gene	Chr5:133394029-133429429 (-)

Human Ortholog

AGFG2, ArfGAP with FG repeats 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGFG2, ArfGAP with FG repeats 2
Synonyms

HRBL, RABR
Links

HGNC:5177

NCBI Gene ID: 3268

UniProt: O95081
Chr Location

7q22.1; chr7:100539190-100568220 (+) GRCh38

MGI Vertebrate Homology

Agfg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGFG2
Gene Tree

Agfg2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

677
Tissues

6
cDNA Data

43
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN agfg2

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All Sequences

56
RefSeq

10
UniProt

6
CCDS

CCDS19774.1, CCDS80443.1

Ensembl

ENSMUSG00000029722 (Evidence)
NCBI Gene

231801

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029722	Ensembl Gene Model \| MGI Sequence Detail	34264	C57BL/6J	± kb
transcript	ENSMUST00000100544	Ensembl \| MGI Sequence Detail	2858	Not Applicable
polypeptide	ENSMUSP00000098112	Ensembl \| MGI Sequence Detail	490	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000029263 Arf-GAP domain and FG repeat-containing protein 2

(term hierarchy)
InterPro Domains

IPR052248 Arf-GAP domain and FG repeat-containing protein

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like, zinc finger superfamily

IPR001164 Arf GTPase activating protein
GlyGen

Q80WC7 11 sites, 1 O-linked glycan (8 sites)

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All nucleic 43

cDNA 43

Microarray probesets 4

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:113837 Coda L, et al., Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. J Biol Chem. 1998 Jan 30;273(5):3003-12
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Agfg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54025	Chr5:137683009-137683019 (-)	-26 bp
Tssr54024	Chr5:137682927-137682991 (-)	29 bp
Tssr54023	Chr5:137682850-137682865 (-)	130 bp
Tssr54022	Chr5:137667833-137667837 (-)	15,153 bp
Tssr54021	Chr5:137648825-137648827 (-)	34,162 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24