Ndufs1
Gene Detail

Symbol Name ID

Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 MGI:2443241

Synonyms

5830412M15Rik, 9930026A05Rik, MGC:19199, MGC:7850

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:63143596-63176822 bp, - strand From VEGA annotation of GRCm38   33227 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NADH dehydrogenase (ubiquinone) chain 11
Gene Tree: Ndufs1

Human homologs

Human Homolog		NDUFS1, NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NCBI Gene ID		4719
neXtProt AC		NX_P28331
Human Synonyms		CI-75k, CI-75Kd, PRO1304
Human Chr (Location)		2q33-q34; chr2:206987803-207024243 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NDUFS1

Alleles and phenotypes

All alleles(39) : Targeted(2) Gene trapped(37)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	apoptotic mitochondrial changes, ATP metabolic process, ...
Component	membrane, mitochondrial inner membrane, ...
Function	2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (294)    Tissues (121)    Images (39)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	294

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002613 (Evidence)
Ensembl Gene Model	ENSMUSG00000025968 (Evidence)
Entrez Gene	227197 (Evidence)
DFCI	TC1571978, TC1604077, TC1610588, TC1617209, TC1698878
DoTS	DT.101225518, DT.497069, DT.55194182, DT.91441875, DT.97363356, DT.97363364, DT.97365497, DT.99868375
NIA Mouse Gene Index	U021392
EC	1.6.5.3, 1.6.99.3
Consensus CDS Project	CCDS14996.1
International Mouse Knockout Project Status	Ndufs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002613	VEGA Gene Model | MGI Sequence Detail	33227	C57BL/6J
transcript	OTTMUST00000005068	VEGA | MGI Sequence Detail	2661	Not Applicable
polypeptide	OTTMUSP00000002422	VEGA | MGI Sequence Detail	727	Not Applicable

All sequences(59) RefSeq(8) UniProt(3)

Polymorphisms

SNPs(66 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001041	2Fe-2S ferredoxin-type domain
InterPro	IPR012675	Beta-grasp domain
InterPro	IPR006656	Molybdopterin oxidoreductase
InterPro	IPR015405	NADH-quinone oxidoreductase, chain G, C-terminal
InterPro	IPR000283	NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
InterPro	IPR010228	NADH:ubiquinone oxidoreductase, subunit G
InterPro	IPR019574	NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Protein Ontology	PR:000011096	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:172853 Kohr MJ, et al., Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35
All references(42)

Other accession IDs

MGI:1922005