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Ndufs1 Gene Detail
Summary
  • Symbol
    Ndufs1
  • Name
    NADH dehydrogenase (ubiquinone) Fe-S protein 1
  • Synonyms
    5830412M15Rik, 9930026A05Rik, MGC:19199, MGC:7850
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443241
    NCBI Gene: 227197
  • Gene Overview
    MyGene.info: NDUFS1
Location & Maps
more
  • Sequence Map
    Chr1:63143596-63176833 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33238 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.29 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NDUFS1, NADH:ubiquinone oxidoreductase core subunit S1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDUFS1, NADH:ubiquinone oxidoreductase core subunit S1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CI-75k, CI-75Kd, PRO1304
  • Links
    NCBI Gene ID: 4719
    neXtProt AC: NX_P28331

  • Chr Location
    2q33-q34; chr2:206123079-206159519 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NDUFS1 associations

Human Disease Mouse Models
       Mitochondrial Complex I Deficiency   OMIM: 252010
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    1
  • Gene trapped
    37
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ndufs1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002613 VEGA Gene Model | MGI Sequence Detail 33238 C57BL/6J ±  kb
transcript OTTMUST00000005068 VEGA | MGI Sequence Detail 2661 Not Applicable  
polypeptide OTTMUSP00000002422 VEGA | MGI Sequence Detail 727 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000011096 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
  • EC
  • InterPro Domains
    IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
    IPR012675 Beta-grasp domain
    IPR006656 Molybdopterin oxidoreductase
    IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain
    IPR015405 NADH-quinone oxidoreductase, chain G, C-terminal
    IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
    IPR010228 NADH:ubiquinone oxidoreductase, subunit G
    IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1922005
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory