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Ndufs1 Gene Detail
Summary
  • Symbol
    Ndufs1
  • Name
    NADH:ubiquinone oxidoreductase core subunit S1
  • Synonyms
    5830412M15Rik, 9930026A05Rik, MGC:19199, MGC:7850
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443241
    NCBI Gene: 227197
  • Gene Overview
    MyGene.info: NDUFS1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:63143596-63176833 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33238 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.29 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NDUFS1, NADH:ubiquinone oxidoreductase core subunit S1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDUFS1, NADH:ubiquinone oxidoreductase core subunit S1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CI-75k, CI-75Kd, PRO1304
  • Links
    NCBI Gene ID: 4719
    neXtProt AC: NX_P28331
    UniProt: P28331

  • Chr Location
    2q33.3; chr2:206121971-206159519 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NDUFS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002613 VEGA Gene Model | MGI Sequence Detail 33238 C57BL/6J ±  kb
    transcript OTTMUST00000005068 VEGA | MGI Sequence Detail 2661 Not Applicable  
    polypeptide OTTMUSP00000002422 VEGA | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      79 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000011096 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    • EC
    • InterPro Domains
      IPR036010 2Fe-2S ferredoxin-like superfamily
      IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
      IPR006656 Molybdopterin oxidoreductase
      IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain
      IPR015405 NADH-quinone oxidoreductase, chain G, C-terminal
      IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
      IPR010228 NADH:ubiquinone oxidoreductase, subunit G
      IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922005
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory