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Ndufs1
Gene Detail
 Symbol
Name
ID
Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
MGI:2443241
Synonyms 5830412M15Rik, 9930026A05Rik, MGC:19199, MGC:7850
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:63143596-63176822 bp, - strand
From VEGA annotation of GRCm38

  33227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NADH dehydrogenase (ubiquinone) chain 11
Gene Tree: Ndufs1

Human
homologs
Human Homolog NDUFS1, NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NCBI Gene ID 4719
neXtProt AC  NX_P28331
Human Synonyms  CI-75k, CI-75Kd, PRO1304
Human Chr (Location)  2q33-q34; chr2:206123079-206159519 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NDUFS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(37) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ndufs1 interacts with 61 markers (Mir1b, Mir19a, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process apoptotic mitochondrial changes, ATP metabolic process, ...
Component membrane, mitochondrial inner membrane, ...
Function 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (294)    Tissues (121)    Images (39)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 294
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002613 (Evidence)
Ensembl Gene ModelENSMUSG00000025968 (Evidence)
Entrez Gene227197 (Evidence)
DFCITC1571978, TC1604077, TC1610588, TC1617209, TC1698878
DoTSDT.101225518, DT.497069, DT.55194182, DT.91441875, DT.97363356, DT.97363364, DT.97365497, DT.99868375
NIA Mouse Gene IndexU021392
EC1.6.5.3, 1.6.99.3
Consensus CDS ProjectCCDS14996.1
International Mouse Knockout Project StatusNdufs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002613 VEGA Gene Model | MGI Sequence Detail 33227 C57BL/6J ±  kb
transcript OTTMUST00000005068 VEGA | MGI Sequence Detail 2661 Not Applicable 
polypeptide OTTMUSP00000002422 VEGA | MGI Sequence Detail 727 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001041 2Fe-2S ferredoxin-type domain
InterPro IPR012675 Beta-grasp domain
InterPro IPR006656 Molybdopterin oxidoreductase
InterPro IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain
InterPro IPR015405 NADH-quinone oxidoreductase, chain G, C-terminal
InterPro IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
InterPro IPR010228 NADH:ubiquinone oxidoreductase, subunit G
InterPro IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Protein Ontology PR:000011096 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:172853 Kohr MJ, et al., Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35
All references(44)
Other
accession IDs
MGI:1922005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory