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Ndufs1 Gene Detail
Summary
  • Symbol
    Ndufs1
  • Name
    NADH:ubiquinone oxidoreductase core subunit S1
  • Synonyms
    5830412M15Rik, 9930026A05Rik, MGC:19199, MGC:7850
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443241
    NCBI Gene: 227197
  • Gene Overview
    MyGene.info: NDUFS1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:63143592-63176822 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443241
protein coding gene Chr1:63143592-63176833 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016085
protein coding gene Chr1:63283109-63319567 (-)
A/J MGP_AJ_G0016068
protein coding gene Chr1:61043131-61076496 (-)
AKR/J MGP_AKRJ_G0016025
protein coding gene Chr1:62723451-62757534 (-)
BALB/cJ MGP_BALBcJ_G0016023
protein coding gene Chr1:61129657-61163382 (-)
C3H/HeJ MGP_C3HHeJ_G0015855
protein coding gene Chr1:63002838-63036207 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016476
protein coding gene Chr1:65715909-65752971 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014197
protein coding gene Chr1:57157643-57194120 (-)
CAST/EiJ MGP_CASTEiJ_G0015438
protein coding gene Chr1:62265926-62301153 (-)
CBA/J MGP_CBAJ_G0015827
protein coding gene Chr1:67812643-67855080 (-)
DBA/2J MGP_DBA2J_G0015928
protein coding gene Chr1:60448685-60491550 (-)
FVB/NJ MGP_FVBNJ_G0015931
protein coding gene Chr1:59751165-59783973 (-)
LP/J MGP_LPJ_G0016000
protein coding gene Chr1:64171831-64204254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015951
protein coding gene Chr1:70709679-70760481 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016523
protein coding gene Chr1:62704039-62741338 (-)
PWK/PhJ MGP_PWKPhJ_G0015225
protein coding gene Chr1:59825599-59861003 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015004
protein coding gene Chr1:62210441-62260616 (-)
WSB/EiJ MGP_WSBEiJ_G0015500
protein coding gene Chr1:62430298-62464810 (-)



Homology
more
  • Human Ortholog
    NDUFS1, NADH:ubiquinone oxidoreductase core subunit S1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDUFS1, NADH:ubiquinone oxidoreductase core subunit S1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CI-75k, CI-75Kd, PRO1304
  • Links
    NCBI Gene ID: 4719
    neXtProt AC: NX_P28331
    UniProt: P28331

  • Chr Location
    2q33.3; chr2:206121971-206159519 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NDUFS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227197 NCBI Gene Model | MGI Sequence Detail 33231 C57BL/6J ±  kb
    transcript NM_001160038 RefSeq | MGI Sequence Detail 2936 C57BL/6  
    polypeptide Q91VD9 UniProt | EBI | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000011096 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    • PDB
    • EC
    • InterPro Domains
      IPR036010 2Fe-2S ferredoxin-like superfamily
      IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
      IPR006656 Molybdopterin oxidoreductase
      IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain
      IPR015405 NADH-quinone oxidoreductase, chain G, C-terminal
      IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
      IPR010228 NADH:ubiquinone oxidoreductase, subunit G
      IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922005
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory