Slc4a5 MGI Mouse Gene Detail - MGI:2443220 - solute carrier family 4, sodium bicarbonate cotransporter, member 5

Symbol

Slc4a5
Name

solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms

C330016K18Rik

Feature Type

protein coding gene
IDs

MGI:2443220
NCBI Gene: 232156
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:83196810-83281927 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

2 experiments

SNPs within 2kb

4153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443220	protein coding gene	Chr6:83184561-83281927 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030927	protein coding gene	Chr6:84229866-84308270 (+)
A/J	MGP_AJ_G0030896	protein coding gene	Chr6:81016099-81098994 (+)
AKR/J	MGP_AKRJ_G0030824	protein coding gene	Chr6:83353535-83450719 (+)
BALB/cJ	MGP_BALBcJ_G0030906	protein coding gene	Chr6:81036928-81122658 (+)
C3H/HeJ	MGP_C3HHeJ_G0030804	protein coding gene	Chr6:100948258-101037013 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031366	protein coding gene	Chr6:86524964-86619937 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028552	protein coding gene	Chr6:79373159-79451059 (+)
CAST/EiJ	MGP_CASTEiJ_G0030015	protein coding gene	Chr6:83361628-83457549 (+)
CBA/J	MGP_CBAJ_G0030593	protein coding gene	Chr6:89943528-90033638 (+)
DBA/2J	MGP_DBA2J_G0030746	protein coding gene	Chr6:80333883-80416909 (+)
FVB/NJ	MGP_FVBNJ_G0030699	protein coding gene	Chr6:79535527-79622764 (+)
LP/J	MGP_LPJ_G0030825	protein coding gene	Chr6:84232981-84315498 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030735	protein coding gene	Chr6:94250671-94336123 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031390	protein coding gene	Chr6:83166541-83253912 (+)
PWK/PhJ	MGP_PWKPhJ_G0029730	protein coding gene	Chr6:79229700-79316827 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029558	protein coding gene	Chr6:82008815-82100505 (+)
WSB/EiJ	MGP_WSBEiJ_G0030096	protein coding gene	Chr6:83594200-83690330 (+)

Human Ortholog

SLC4A5, solute carrier family 4 member 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC4A5, solute carrier family 4 member 5
Synonyms

NBC4, NBCe2
Links

HGNC:18168

NCBI Gene ID: 57835

UniProt: Q9BY07
Chr Location

2p13.1; chr2:74216242-74343416 (-) GRCh38

MGI Vertebrate Homology

Slc4a5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC4A5
Gene Tree

Slc4a5

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Phenotype Summary

31 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

1
Spontaneous

1
Targeted

5
Genomic Mutations

2 involving Slc4a5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit arterial hypertension and renal metabolic acidosis.

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All GO Annotations

37
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

98
cDNA Data

25
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc4a5b

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All Sequences

61
RefSeq

13
UniProt

4
CCDS

CCDS51819.1

Ensembl

ENSMUSG00000068323 (Evidence)
NCBI Gene

232156

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068323	Ensembl Gene Model \| MGI Sequence Detail	85118	C57BL/6J	± kb
transcript	ENSMUST00000113900	Ensembl \| MGI Sequence Detail	3630	Not Applicable
polypeptide	ENSMUSP00000109533	Ensembl \| MGI Sequence Detail	1116	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015161 electrogenic sodium bicarbonate cotransporter 4

(term hierarchy)
InterPro Domains

IPR013769 Band 3 cytoplasmic domain

IPR003020 Bicarbonate transporter, eukaryotic

IPR011531 Bicarbonate transporter-like, transmembrane domain

IPR016152 Phosphotransferase/anion transporter

IPR003024 Sodium bicarbonate cotransporter

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All nucleic 29

Genomic 1

cDNA 25

Primer pair 3

Microarray probesets 2

Summaries

All 53

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 18
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:358138 Morikawa R, et al., The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision. Neuron. 2024 Sep 18;

TSS for Slc4a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57339	Chr6:83214503-83214543 (+)	17,713 bp
Tssr57340	Chr6:83214544-83214562 (+)	17,743 bp
Tssr57341	Chr6:83214631-83214643 (+)	17,827 bp
Tssr57342	Chr6:83216221-83216261 (+)	19,431 bp
Tssr1907	Chr6:83225629-83225631 (+)	28,820 bp
Tssr57343	Chr6:83254337-83254346 (+)	57,532 bp
Tssr57344	Chr6:83254357-83254398 (+)	57,568 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24