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Slc4a5
Gene Detail
 Symbol
Name
ID
Slc4a5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
MGI:2443220
Synonyms C330016K18Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:83219828-83304945 bp, + strand
From VEGA annotation of GRCm38

  85118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31125  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc4a5

Human
homologs
Human Homolog SLC4A5, solute carrier family 4 (sodium bicarbonate cotransporter), member 5
NCBI Gene ID 57835
neXtProt AC  NX_Q9BY07
Human Synonyms  NBC4
Human Chr (Location)  2p13; chr2:74216242-74343407 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit arterial hypertension and renal metabolic acidosis.
 
Interactions
Slc4a5 interacts with 213 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cerebrospinal fluid secretion, epithelial cell development, ...
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (126)    Tissues (97)    Images (21)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 126
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(25) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000022619 (Evidence)
Ensembl Gene ModelENSMUSG00000068323 (Evidence)
Entrez Gene232156 (Evidence)
UniGene333189
DFCITC1606581, TC1609897, TC1621002, TC1628066, TC1632789
DoTSDT.101359813, DT.102548164, DT.103561799, DT.55226310
NIA Mouse Gene IndexU007081
Consensus CDS ProjectCCDS51819.1
International Mouse Knockout Project StatusSlc4a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022619 VEGA Gene Model | MGI Sequence Detail 85118 C57BL/6J ±  kb
transcript OTTMUST00000054185 VEGA | MGI Sequence Detail 3630 Not Applicable 
polypeptide OTTMUSP00000025825 VEGA | MGI Sequence Detail 1116 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(15) UniProt(4)
Polymorphisms SNPs within 2kb(721 from dbSNP Build 137)    SNPs within 2kb including multiple locations(723)
Protein-related
information
ResourceIDDescription
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015161 electrogenic sodium bicarbonate cotransporter 4
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory