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Slc4a5 Gene Detail
Summary
  • Symbol
    Slc4a5
  • Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 5
  • Synonyms
    C330016K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443220
    NCBI Gene: 232156
  • Gene Overview
    MyGene.info: SLC4A5
Location & Maps
more
  • Sequence Map
    Chr6:83219828-83304945 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      85118 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC4A5, solute carrier family 4 member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC4A5, solute carrier family 4 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NBC4, NBCe2
  • Links
    NCBI Gene ID: 57835
    neXtProt AC: NX_Q9BY07

  • Chr Location
    2p13; chr2:74216242-74343407 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Slc4a5
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a knock-out allele exhibit arterial hypertension and renal metabolic acidosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    126
  • Tissues
    97
  • cDNA Data
    25
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022619 VEGA Gene Model | MGI Sequence Detail 85118 C57BL/6J ±  kb
transcript OTTMUST00000054185 VEGA | MGI Sequence Detail 3630 Not Applicable  
polypeptide OTTMUSP00000025825 VEGA | MGI Sequence Detail 1116 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    733 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR013769 Band 3 cytoplasmic domain
    IPR011531 Bicarbonate transporter, C-terminal
    IPR003020 Bicarbonate transporter, eukaryotic
    IPR016152 Phosphotransferase/anion transporter
    IPR003024 Sodium bicarbonate cotransporter
Molecular
Reagents
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  • All nucleic 27
    cDNA 25
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory