Slc4a5
Gene Detail

Symbol Name ID

Slc4a5 solute carrier family 4, sodium bicarbonate cotransporter, member 5 MGI:2443220

Synonyms

C330016K18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:83219828-83304945 bp, + strand From VEGA annotation of GRCm38   85118 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31125  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Slc4a5

Human homologs

Human Homolog		SLC4A5, solute carrier family 4 (sodium bicarbonate cotransporter), member 5
NCBI Gene ID		57835
neXtProt AC		NX_Q9BY07
Human Synonyms		NBC4
Human Chr (Location)		2p13; chr2:74216242-74343407 (-)  GRCh38

Alleles and phenotypes

All alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit arterial hypertension and renal metabolic acidosis.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cerebrospinal fluid secretion, epithelial cell development, ...
Component	cellular_component
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (126)    Tissues (97)    Images (21)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	126

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(25) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000022619 (Evidence)
Ensembl Gene Model	ENSMUSG00000068323 (Evidence)
Entrez Gene	232156 (Evidence)
UniGene	333189
DFCI	TC1606581, TC1609897, TC1621002, TC1628066, TC1632789
DoTS	DT.101359813, DT.102548164, DT.103561799, DT.55226310
NIA Mouse Gene Index	U007081
Consensus CDS Project	CCDS51819.1
International Mouse Knockout Project Status	Slc4a5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022619	VEGA Gene Model | MGI Sequence Detail	85118	C57BL/6J
transcript	OTTMUST00000054185	VEGA | MGI Sequence Detail	3630	Not Applicable
polypeptide	OTTMUSP00000025825	VEGA | MGI Sequence Detail	1116	Not Applicable

All sequences(65) RefSeq(15) UniProt(4)

Polymorphisms

SNPs within 2kb(721 from dbSNP Build 137)    SNPs within 2kb including multiple locations(723)

Protein-related information

Resource	ID	Description
InterPro	IPR013769	Band 3 cytoplasmic domain
InterPro	IPR011531	Bicarbonate transporter, C-terminal
InterPro	IPR003020	Bicarbonate transporter, eukaryotic
InterPro	IPR016152	Phosphotransferase/anion transporter
InterPro	IPR003024	Sodium bicarbonate cotransporter
Protein Ontology	PR:000015161	electrogenic sodium bicarbonate cotransporter 4

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(31)