Tmem260 MGI Mouse Gene Detail - MGI:2443219

Symbol

Tmem260
Name

transmembrane protein 260
Synonyms

6720456H20Rik

Feature Type

protein coding gene
IDs

MGI:2443219
NCBI Gene: 218989
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:48683581-48761703 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 25.06 cM
Mapping Data

2 experiments

SNPs within 2kb

4370 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443219	protein coding gene	Chr14:48683580-48797640 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021226	protein coding gene	Chr14:42288618-42362161 (+)
A/J	MGP_AJ_G0021175	protein coding gene	Chr14:40969527-41039295 (+)
AKR/J	MGP_AKRJ_G0021153	protein coding gene	Chr14:42572125-42640447 (+)
BALB/cJ	MGP_BALBcJ_G0021178	protein coding gene	Chr14:41026118-41095912 (+)
C3H/HeJ	MGP_C3HHeJ_G0020961	protein coding gene	Chr14:42355732-42426543 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021613	protein coding gene	Chr14:44048746-44117236 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019172	protein coding gene	Chr14:40301896-40369871 (+)
CAST/EiJ	MGP_CASTEiJ_G0020487	protein coding gene	Chr14:39496058-39562970 (+)
CBA/J	MGP_CBAJ_G0020928	protein coding gene	Chr14:45466791-45539003 (+)
DBA/2J	MGP_DBA2J_G0021051	protein coding gene	Chr14:40854926-40923456 (+)
FVB/NJ	MGP_FVBNJ_G0021036	protein coding gene	Chr14:40599681-40668406 (+)
LP/J	MGP_LPJ_G0021120	protein coding gene	Chr14:42538036-42608207 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021061	protein coding gene	Chr14:44783315-44854261 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021646	protein coding gene	Chr14:42113647-42183075 (+)
PWK/PhJ	MGP_PWKPhJ_G0020235	protein coding gene	Chr14:37744453-37816096 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020060	protein coding gene	Chr14:38246393-38314767 (+)
WSB/EiJ	MGP_WSBEiJ_G0020543	protein coding gene	Chr14:42214278-42285560 (+)

Human Ortholog

TMEM260, transmembrane protein 260

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM260, transmembrane protein 260
Synonyms

C14orf101, SHDRA
Links

HGNC:20185

NCBI Gene ID: 54916

UniProt: Q9NX78
Chr Location

14q22.3; chr14:56488354-56663165 (+) GRCh38

MGI Vertebrate Homology

Tmem260 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM260
Gene Tree

Tmem260

Diseases

3 with human TMEM260 associations

				Human Disease	Mouse Models
				non-Hodgkin lymphoma IDs non-Hodgkin lymphoma DOID:0060060 ICD10CM:C85.9 MESH:D008228 NCI:C3211 OMIM:605027 ORDO:547 UMLS_CUI:C0024305
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423
				T-cell non-Hodgkin lymphoma IDs T-cell non-Hodgkin lymphoma DOID:0081312 MESH:D016399 NCI:C3466 UMLS_CUI:C0079772

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Tmem260
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

54

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem260

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All Sequences

80
RefSeq

14
UniProt

6
CCDS

CCDS26993.2, CCDS79318.1

Ensembl

ENSMUSG00000036339 (Evidence)
NCBI Gene

218989

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036339	Ensembl Gene Model \| MGI Sequence Detail	78123	C57BL/6J	± kb
transcript	ENSMUST00000226422	Ensembl \| MGI Sequence Detail	6333	Not Applicable
polypeptide	ENSMUSP00000154083	Ensembl \| MGI Sequence Detail	712	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000060120 protein O-mannosyl-transferase TMEM260

(term hierarchy)
EC

2.4.1.109
InterPro Domains

IPR052724 Glycosyltransferase 117 domain-containing protein

IPR021280 Protein O-mannosyl-transferase TMEM260-like
GlyGen

Q8BMD6 2 sites

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All nucleic 54

cDNA 54

Microarray probesets 2

Summaries

All 30

Gene Ontology 5

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem260:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125340	Chr14:48683722-48683733 (+)	147 bp
Tssr125341	Chr14:48683797-48683886 (+)	261 bp
Tssr125342	Chr14:48701639-48701641 (+)	18,059 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24