Dlx6os1 MGI Mouse Gene Detail - MGI:2443217 - distal-less homeobox 6, opposite strand 1

Symbol

Dlx6os1
Name

distal-less homeobox 6, opposite strand 1
Synonyms

A230055N17Rik, Dlx6as1, Dlx6os1, Evf1, Evf-1, Evf1/2, Evf2, Evf-2, mEvf-1, Shhrs

Feature Type

antisense lncRNA gene

BioType Conflict
IDs

MGI:2443217
NCBI Gene: 320038
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr6:6820543-6871627 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 2.68 cM
Mapping Data

3 experiments

SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443217	antisense lncRNA gene	Chr6:6749740-6871632 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0004230	antisense lncRNA gene	Chr6:3735930-3791804 (-)
A/J	MGP_AJ_G0004208	antisense lncRNA gene	Chr6:3591318-3642891 (-)
AKR/J	MGP_AKRJ_G0004189	antisense lncRNA gene	Chr6:3694125-3748897 (-)
BALB/cJ	MGP_BALBcJ_G0004195	antisense lncRNA gene	Chr6:3542852-3596044 (-)
C3H/HeJ	MGP_C3HHeJ_G0004143	antisense lncRNA gene	Chr6:3630522-3686399 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0004344	antisense lncRNA gene	Chr6:3821772-3879441 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003817	antisense lncRNA gene	Chr6:3213335-3253235 (-)
CAST/EiJ	MGP_CASTEiJ_G0004105	antisense lncRNA gene	Chr6:3649742-3705840 (-)
CBA/J	MGP_CBAJ_G0004137	antisense lncRNA gene	Chr6:3968613-4020941 (-)
DBA/2J	MGP_DBA2J_G0004153	antisense lncRNA gene	Chr6:3531115-3583052 (-)
FVB/NJ	MGP_FVBNJ_G0004169	antisense lncRNA gene	Chr6:3515735-3568762 (-)
LP/J	MGP_LPJ_G0004231	antisense lncRNA gene	Chr6:3683056-3736029 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0004159	antisense lncRNA gene	Chr6:3997044-4054371 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0004341	antisense lncRNA gene	Chr6:3630448-3687555 (-)
PWK/PhJ	MGP_PWKPhJ_G0004058	antisense lncRNA gene	Chr6:3469705-3522431 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0004002	antisense lncRNA gene	Chr6:3689264-3740256 (-)
WSB/EiJ	MGP_WSBEiJ_G0004141	antisense lncRNA gene	Chr6:3629000-3683793 (-)

Human Ortholog

DLX6-AS1, DLX6 antisense RNA 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DLX6-AS1, DLX6 antisense RNA 1
Synonyms

DLX6AS, DLX6-AS, Evf-2, NCRNA00212
Links

HGNC:37151

NCBI Gene ID: 285987
Chr Location

7q21.3; chr7:96955141-97014088 (-) GRCh38

MGI Vertebrate Homology

Dlx6os1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: DLX6-AS1
Gene Tree

Dlx6os1

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Dlx6os1
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in allele exhibit temporary loss of GABAergic interneurons and decreased inhibitory postsynaptic currents.

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

916
Tissues

95
cDNA Data

22
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

3

Ensembl

ENSMUSG00000090063 (Evidence)
NCBI Gene

320038

Representative Sequences				Length	Strain/Species	Flank
	genomic	320038	NCBI Gene Model \| MGI Sequence Detail	51085	C57BL/6J	± kb
	transcript	NR_015388	RefSeq \| MGI Sequence Detail	4266	ZRU/MplStud

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All nucleic 30

cDNA 22

Primer pair 6

Other 2

Microarray probesets 3

Summaries

All 48

Developmental Gene Expression 22

Diseases 1

Gene Ontology 1

Phenotypes 15
Earliest

J:76480 Robledo RF, et al., The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 1;16(9):1089-101
Latest

J:345332 Guo J, et al., Long non-coding RNA DLX6-AS1 is the key mediator of glomerular podocyte injury and albuminuria in diabetic nephropathy by targeting the miR-346/GSK-3beta signaling pathway. Cell Death Dis. 2023 Feb 28;14(2):172

TSS for Dlx6os1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59784	Chr6:6871621-6871635 (-)	-1 bp
Tssr59783	Chr6:6871588-6871589 (-)	38 bp
Tssr59782	Chr6:6871562-6871573 (-)	59 bp
Tssr59781	Chr6:6871533-6871538 (-)	91 bp
Tssr59780	Chr6:6869517-6869539 (-)	2,099 bp
Tssr59779	Chr6:6869489-6869503 (-)	2,131 bp
Tssr59778	Chr6:6869365-6869368 (-)	2,260 bp
Tssr59777	Chr6:6862839-6862856 (-)	8,779 bp
Tssr59776	Chr6:6862828-6862838 (-)	8,794 bp
Tssr59775	Chr6:6861737-6861740 (-)	9,888 bp
Tssr59774	Chr6:6861678-6861685 (-)	9,945 bp
Tssr59773	Chr6:6861642-6861655 (-)	9,978 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23