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Rbm15 Gene Detail
Summary
  • Symbol
    Rbm15
  • Name
    RNA binding motif protein 15
  • Synonyms
    C230088J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443205
    NCBI Gene: 229700
  • Gene Overview
    MyGene.info: RBM15
Location & Maps
more
  • Sequence Map
    Chr3:107325421-107333673 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8253 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RBM15, RNA binding motif protein 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBM15, RNA binding motif protein 15
    Orthology source: HomoloGene
  • Synonyms
    OTT, OTT1, SPEN
  • Links
    NCBI Gene ID: 64783
    neXtProt AC: NX_Q96T37

  • Chr Location
    1p13; chr1:110338426-110373218 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23383
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RBM15
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Rbm15
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052948 VEGA Gene Model | MGI Sequence Detail 8253 C57BL/6J ±  kb
transcript OTTMUST00000132497 VEGA | MGI Sequence Detail 4343 Not Applicable  
polypeptide OTTMUSP00000070641 VEGA | MGI Sequence Detail 962 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
    IPR012921 Spen paralogue and orthologue SPOC, C-terminal
    IPR010912 Spen paralogue/orthologue C-terminal, metazoa
    IPR016194 SPOC-like, C-terminal domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:185157 Xiao N, et al., Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood. 2012 May 24;119(21):4898-907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory