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Rbm15
Gene Detail
 Symbol
Name
ID
Rbm15
RNA binding motif protein 15
MGI:2443205
Synonyms C230088J01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:107326110-107333289 bp, - strand
From NCBI annotation of GRCm38

  7180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rbm15

Human
homologs
Human Homolog RBM15, RNA binding motif protein 15
NCBI Gene ID 64783
neXtProt AC  NX_Q96T37
Human Synonyms  OTT, OTT1, SPEN
Human Chr (Location)  1p13; chr1:110339323-110346681 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes.
 
Interactions
Rbm15 interacts with 79 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of myeloid cell differentiation, negative regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function poly(A) RNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (28)    Images (7)
Theiler Stages: 21, 27
Assay TypeResults
RNA in situ 26
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000048109 (Evidence)
Entrez Gene229700 (Evidence)
DFCITC1597323, TC1655896, TC1679255
DoTSDT.101131754, DT.101355432, DT.94217993
NIA Mouse Gene IndexU024495
Consensus CDS ProjectCCDS38590.1
International Mouse Knockout Project StatusRbm15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 229700 NCBI Gene Model | MGI Sequence Detail 7180 C57BL/6J ±  kb
transcript NM_001045807 RefSeq | MGI Sequence Detail 3270 Not Specified 
polypeptide NP_001039272 RefSeq | MGI Sequence Detail 962 Not Specified 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
InterPro IPR012921 Spen paralogue and orthologue SPOC, C-terminal
InterPro IPR010912 Spen paralogue/orthologue C-terminal, metazoa
InterPro IPR016194 SPOC like C-terminal domain
Protein Ontology PR:000029709 RNA-binding protein 15
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185157 Xiao N, et al., Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood. 2012 May 24;119(21):4898-907
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory