Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes.
|Process||negative regulation of myeloid cell differentiation, negative regulation of transcription from RNA polymerase II promoter, ...|
|Function||poly(A) RNA binding, protein binding|
|InterPro||IPR012677||Nucleotide-binding, alpha-beta plait|
|InterPro||IPR000504||RNA recognition motif domain|
|InterPro||IPR012921||Spen paralogue and orthologue SPOC, C-terminal|
|InterPro||IPR010912||Spen paralogue/orthologue C-terminal, metazoa|
|InterPro||IPR016194||SPOC like C-terminal domain|
|Protein Ontology||PR:000029709||RNA-binding protein 15|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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