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Rbm15
Gene Detail
Symbol

Name
ID
Rbm15
RNA binding motif protein 15
MGI:2443205
Synonyms
C230088J01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:107325421-107333673 bp, - strand
From VEGA annotation of GRCm38

  8253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RBM15
Gene Tree: Rbm15

Human
homologs
RBM15, RNA binding motif protein 15
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64783
neXtProt AC: NX_Q96T37

Human Synonyms: OTT, OTT1, SPEN

Human Chr (Location): 1p13; chr1:110338426-110373218 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes.
 
Interactions
Rbm15 interacts with 79 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mRNA splicing, via spliceosome, negative regulation of myeloid cell differentiation, ...
Component nucleoplasm, nucleus
Function nucleic acid binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (28)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 2
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rbm15    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000052948 (Evidence)
Ensembl Gene Model ENSMUSG00000048109 (Evidence)
Entrez Gene 229700 (Evidence)
DFCI TC1597323, TC1655896, TC1679255
DoTS DT.101131754, DT.101355432, DT.94217993
NIA Mouse Gene Index U024495
Consensus CDS Project CCDS38590.1
International Mouse Phenotyping Consortium Status Rbm15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052948 VEGA Gene Model | MGI Sequence Detail 8253 C57BL/6J ±  kb
transcript OTTMUST00000132497 VEGA | MGI Sequence Detail 4343 Not Applicable 
polypeptide OTTMUSP00000070641 VEGA | MGI Sequence Detail 962 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding alpha-beta plait domain
InterPro IPR000504 RNA recognition motif domain
InterPro IPR012921 Spen paralogue and orthologue SPOC, C-terminal
InterPro IPR010912 Spen paralogue/orthologue C-terminal, metazoa
InterPro IPR016194 SPOC-like, C-terminal domain
Protein Ontology PR:000029709 RNA-binding protein 15
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185157 Xiao N, et al., Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood. 2012 May 24;119(21):4898-907
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory