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Rbm15 Gene Detail
Summary
  • Symbol
    Rbm15
  • Name
    RNA binding motif protein 15
  • Synonyms
    C230088J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443205
    NCBI Gene: 229700
  • Gene Overview
    MyGene.info: RBM15
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107325421-107333673 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443205
protein coding gene Chr3:107305511-107334967 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027747
protein coding gene Chr3:108805643-108814873 (-)
A/J MGP_AJ_G0027707
protein coding gene Chr3:105361087-105369352 (-)
AKR/J MGP_AKRJ_G0027672
protein coding gene Chr3:107936926-107945160 (-)
BALB/cJ MGP_BALBcJ_G0027719
protein coding gene Chr3:105059833-105068359 (-)
C3H/HeJ MGP_C3HHeJ_G0027449
protein coding gene Chr3:108277310-108285586 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028163
protein coding gene Chr3:112885810-112894097 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025501
protein coding gene Chr3:101524322-101532555 (-)
CAST/EiJ MGP_CASTEiJ_G0026905
protein coding gene Chr3:107655590-107664842 (-)
CBA/J MGP_CBAJ_G0027424
protein coding gene Chr3:116702683-116710909 (-)
DBA/2J MGP_DBA2J_G0027566
protein coding gene Chr3:104563736-104571988 (-)
FVB/NJ MGP_FVBNJ_G0027534
protein coding gene Chr3:102443760-102452635 (-)
LP/J MGP_LPJ_G0027673
protein coding gene Chr3:110224828-110233068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027564
protein coding gene Chr3:122830094-122840799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028218
protein coding gene Chr3:107529744-107537969 (-)
PWK/PhJ MGP_PWKPhJ_G0026631
protein coding gene Chr3:104290933-104299206 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026451
protein coding gene Chr3:105661409-105669630 (-)
WSB/EiJ MGP_WSBEiJ_G0026985
protein coding gene Chr3:108051757-108062887 (-)



Homology
more
  • Human Ortholog
    RBM15, RNA binding motif protein 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBM15, RNA binding motif protein 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OTT, OTT1, SPEN
  • Links
    NCBI Gene ID: 64783
    neXtProt AC: NX_Q96T37
    UniProt: Q96T37

  • Chr Location
    1p13.3; chr1:110338426-110373005 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23383
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RBM15
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048109 Ensembl Gene Model | MGI Sequence Detail 8253 C57BL/6J ±  kb
    transcript ENSMUST00000061772 Ensembl | MGI Sequence Detail 4343 Not Applicable  
    polypeptide ENSMUSP00000054424 Ensembl | MGI Sequence Detail 962 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034470 RBM15, RNA recognition motif 1
      IPR034472 RBM15, RNA recognition motif 2
      IPR034473 RBM15, RNA recognition motif 3
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR012921 Spen paralogue and orthologue SPOC, C-terminal
      IPR010912 Spen paralogue/orthologue C-terminal, metazoa
      IPR016194 SPOC-like, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:261836 Xiao N, et al., Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl. Blood. 2015 Feb 5;125(6):941-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory