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Zfp384 Gene Detail
Summary
  • Symbol
    Zfp384
  • Name
    zinc finger protein 384
  • Synonyms
    C130073D16Rik, Ciz, Nmp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443203
    NCBI Gene: 269800
  • Gene Overview
    MyGene.info: ZNF384
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125009162-125037870 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443203
protein coding gene Chr6:125009145-125037870 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031281
protein coding gene Chr6:128324682-128362072 (+)
A/J MGP_AJ_G0031251
protein coding gene Chr6:123490573-123519989 (+)
AKR/J MGP_AKRJ_G0031179
protein coding gene Chr6:126862724-126895775 (+)
BALB/cJ MGP_BALBcJ_G0031259
protein coding gene Chr6:123088451-123117331 (+)
C3H/HeJ MGP_C3HHeJ_G0030982
protein coding gene Chr6:126920630-126950584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031715
protein coding gene Chr6:131709511-131741637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028865
protein coding gene Chr6:120695652-120725901 (+)
CAST/EiJ MGP_CASTEiJ_G0030363
protein coding gene Chr6:127127181-127155868 (+)
CBA/J MGP_CBAJ_G0030943
protein coding gene Chr6:136746560-136781378 (+)
DBA/2J MGP_DBA2J_G0031099
protein coding gene Chr6:122418337-122452008 (+)
FVB/NJ MGP_FVBNJ_G0031049
protein coding gene Chr6:121321664-121358188 (+)
LP/J MGP_LPJ_G0031179
protein coding gene Chr6:128495150-128525071 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031087
protein coding gene Chr6:140795866-140829613 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031750
protein coding gene Chr6:126757083-126787423 (+)
PWK/PhJ MGP_PWKPhJ_G0030078
protein coding gene Chr6:120655736-120683010 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029907
protein coding gene Chr6:124838233-124868446 (+)
WSB/EiJ MGP_WSBEiJ_G0030448
protein coding gene Chr6:127123062-127153338 (+)



Homology
more
  • Human Ortholog
    ZNF384, zinc finger protein 384
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ZNF384, zinc finger protein 384
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAGH1, CAGH1A, CIZ, ERDA2, NMP4, NP, TNRC1
  • Links
    NCBI Gene ID: 171017
    neXtProt AC: NX_Q8TF68
    UniProt: Q8TF68

  • Chr Location
    chr12:6666477-6689572 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15849
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNF384
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice are small and males have a small testis. Some males develop infertility and exhibit variable degrees of spermatogenic cell degeneration within the seminiferous tubules and increased apoptosis of spermatogenic cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269800 NCBI Gene Model | MGI Sequence Detail 28709 C57BL/6J ±  kb
    transcript NM_175557 RefSeq | MGI Sequence Detail 3198 C57BL/6  
    polypeptide NP_780766 RefSeq | MGI Sequence Detail 584 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 38
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1927291, MGI:2141735
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:75532 Alvarez MB, et al., Assignment of Nmp4 to mouse chromosome 6 band F1 flanked by D6Mit134 and D6Mit255 using radiation hybrid mapping and fluorescence in situ hybridization. Cytogenet Cell Genet. 2001;94(3-4):244-5
    • Latest
      J:246406 Shao Y, et al., Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism. Endocrinology. 2017 Sep 01;158(9):2722-2740

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory