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Slitrk6 Gene Detail
Summary
  • Symbol
    Slitrk6
  • Name
    SLIT and NTRK-like family, member 6
  • Synonyms
    4832410J21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443198
    NCBI Gene: 239250
  • Gene Overview
    MyGene.info: SLITRK6
Location & Maps
more
  • Sequence Map
    Chr14:110748578-110755149 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6572 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 57.20 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DFNMYP
  • Links
    NCBI Gene ID: 84189
    neXtProt AC: NX_Q9H5Y7

  • Chr Location
    13q31.1; chr13:85792787-85799348 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLITRK6 associations

Human Disease Mouse Models
       Deafness and Myopia; DFNMYP   OMIM: 221200
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Slitrk6
  • Incidental Mutations
Homozygous deficient mice show pronounced reduction in cochlear innervation. Innervation to the posterior crista is variably impaired and a there is a loss of neurons in the spiral and vestibular ganglia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045871 Ensembl Gene Model | MGI Sequence Detail 6572 C57BL/6J ±  kb
transcript ENSMUST00000078386 Ensembl | MGI Sequence Detail 4242 Not Applicable  
polypeptide ENSMUSP00000077492 Ensembl | MGI Sequence Detail 840 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015242 SLIT and NTRK-like protein 6
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 20
    cDNA 17
    Primer pair 1
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:225736 Payne S, et al., A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015 Sep 1;405(1):82-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory