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Slitrk6 Gene Detail
Summary
  • Symbol
    Slitrk6
  • Name
    SLIT and NTRK-like family, member 6
  • Synonyms
    4832410J21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443198
    NCBI Gene: 239250
  • Gene Overview
    MyGene.info: SLITRK6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:110748580-110755149 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 57.20 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNMYP
  • Links
    NCBI Gene ID: 84189
    neXtProt AC: NX_Q9H5Y7
    UniProt: Q9H5Y7

  • Chr Location
    13q31.1; chr13:85792787-85799348 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slitrk6 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    4 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deficient mice show pronounced reduction in cochlear innervation. Innervation to the posterior crista is variably impaired and a there is a loss of neurons in the spiral and vestibular ganglia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045871 Ensembl Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
    transcript ENSMUST00000078386 Ensembl | MGI Sequence Detail 4240 Not Applicable  
    polypeptide ENSMUSP00000077492 Ensembl | MGI Sequence Detail 840 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      79 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:240687 Park KU, et al., Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017 Feb 01;58(2):1137-1150

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory