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Slitrk6 Gene Detail
Summary
  • Symbol
    Slitrk6
  • Name
    SLIT and NTRK-like family, member 6
  • Synonyms
    4832410J21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443198
    NCBI Gene: 239250
  • Gene Overview
    MyGene.info: SLITRK6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:110748580-110755149 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 57.20 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443198
protein coding gene Chr14:110748041-110755206 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021642
protein coding gene Chr14:107678469-107685006 (-)
A/J MGP_AJ_G0021601
protein coding gene Chr14:103977570-103984121 (-)
AKR/J MGP_AKRJ_G0021577
protein coding gene Chr14:107057023-107063553 (-)
BALB/cJ MGP_BALBcJ_G0021607
protein coding gene Chr14:104438493-104445014 (-)
C3H/HeJ MGP_C3HHeJ_G0021385
protein coding gene Chr14:107118478-107124991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022046
protein coding gene Chr14:112081096-112087603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019586
protein coding gene Chr14:100365057-100371637 (-)
CAST/EiJ MGP_CASTEiJ_G0020901
protein coding gene Chr14:104539410-104545932 (-)
CBA/J MGP_CBAJ_G0021353
protein coding gene Chr14:116106227-116112755 (-)
DBA/2J MGP_DBA2J_G0021476
protein coding gene Chr14:103560794-103567339 (-)
FVB/NJ MGP_FVBNJ_G0021454
protein coding gene Chr14:102333298-102339819 (-)
LP/J MGP_LPJ_G0021544
protein coding gene Chr14:108617543-108624068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021480
protein coding gene Chr14:120213010-120219563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022070
protein coding gene Chr14:106690344-106696853 (-)
PWK/PhJ MGP_PWKPhJ_G0020645
protein coding gene Chr14:100501969-100508563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020483
protein coding gene Chr14:102736016-102742568 (-)
WSB/EiJ MGP_WSBEiJ_G0020955
protein coding gene Chr14:107342065-107348582 (-)



Homology
more
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLITRK6, SLIT and NTRK like family member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNMYP
  • Links
    NCBI Gene ID: 84189
    neXtProt AC: NX_Q9H5Y7
    UniProt: Q9H5Y7

  • Chr Location
    13q31.1; chr13:85792787-85799348 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slitrk6 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    4 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous deficient mice show pronounced reduction in cochlear innervation. Innervation to the posterior crista is variably impaired and a there is a loss of neurons in the spiral and vestibular ganglia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045871 Ensembl Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
    transcript ENSMUST00000078386 Ensembl | MGI Sequence Detail 4240 Not Applicable  
    polypeptide ENSMUSP00000077492 Ensembl | MGI Sequence Detail 840 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory