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Nceh1 Gene Detail
Summary
  • Symbol
    Nceh1
  • Name
    neutral cholesterol ester hydrolase 1
  • Synonyms
    Aadacl1, B230106I24Rik, CPO-BP, mKIAA1363
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443191
    NCBI Gene: 320024
  • Gene Overview
    MyGene.info: NCEH1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27183004-27245266 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443191
protein coding gene Chr3:27182965-27284608 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027109
protein coding gene Chr3:24492242-24598950 (+)
A/J MGP_AJ_G0027069
protein coding gene Chr3:24311171-24411502 (+)
AKR/J MGP_AKRJ_G0027038
protein coding gene Chr3:24609810-24711022 (+)
BALB/cJ MGP_BALBcJ_G0027081
protein coding gene Chr3:23994862-24094709 (+)
C3H/HeJ MGP_C3HHeJ_G0026822
protein coding gene Chr3:24656746-24770089 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027526
protein coding gene Chr3:25852254-25978738 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024888
protein coding gene Chr3:22332295-22394801 (+)
CAST/EiJ MGP_CASTEiJ_G0026277
protein coding gene Chr3:24489773-24593336 (+)
CBA/J MGP_CBAJ_G0026800
protein coding gene Chr3:26527254-26636028 (+)
DBA/2J MGP_DBA2J_G0026934
protein coding gene Chr3:23867884-23968036 (+)
FVB/NJ MGP_FVBNJ_G0026902
protein coding gene Chr3:23343932-23443098 (+)
LP/J MGP_LPJ_G0027046
protein coding gene Chr3:25169960-25275329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026923
protein coding gene Chr3:29120978-29224073 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027586
protein coding gene Chr3:24336119-24437624 (+)
PWK/PhJ MGP_PWKPhJ_G0026010
protein coding gene Chr3:23323108-23426224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025820
protein coding gene Chr3:23894007-23951638 (+)
WSB/EiJ MGP_WSBEiJ_G0026350
protein coding gene Chr3:24381001-24487867 (+)



Homology
more
  • Human Ortholog
    NCEH1, neutral cholesterol ester hydrolase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NCEH1, neutral cholesterol ester hydrolase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AADACL1, NCEH
  • Links
    NCBI Gene ID: 57552
    neXtProt AC: NX_Q6PIU2
    UniProt: Q6PIU2

  • Chr Location
    3q26.31; chr3:172630645-172711218 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal organophosphorus metabolism and cholesterol homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 320024 NCBI Gene Model | MGI Sequence Detail 62263 C57BL/6J ±  kb
transcript NM_178772 RefSeq | MGI Sequence Detail 4394 C57BL/6  
polypeptide Q8BLF1 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 7
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:215339 Sakai K, et al., Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. J Lipid Res. 2014 Oct;55(10):2033-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory