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Mia3 Gene Detail
Summary
  • Symbol
    Mia3
  • Name
    MIA SH3 domain ER export factor 3
  • Synonyms
    9130229H14Rik, A930039G15Rik, B230399H06Rik, LOC385255, Tango
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443183
    NCBI Gene: 338366
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:183107682-183150894 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1062 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443183
 protein coding gene Chr1:183107091-183151091 (-)
129S1/SvImJ ENSMUSG00200021829
 protein coding gene Chr1:180875604-180918798 (-)
A/J ENSMUSG00195038947
 protein coding gene Chr1:180460843-180504041 (-)
AKR/J ENSMUSG00220019564
 protein coding gene Chr1:179706253-179749597 (-)
BALB/cJ ENSMUSG00180036316
 protein coding gene Chr1:180527028-180570228 (-)
C3H/HeJ ENSMUSG00175038219
 protein coding gene Chr1:180702641-180745837 (-)
C57BL/6NJ ENSMUSG00215014181
 protein coding gene Chr1:179922238-179965464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015010
 protein coding gene Chr1:173270361-173313617 (-)
CAST/EiJ ENSTCUG00005041450
 protein coding gene Chr1:178447708-178490966 (-)
CBA/J ENSMUSG00210018671
 protein coding gene Chr1:180353236-180396520 (-)
DBA/2J ENSMUSG00185033068
 protein coding gene Chr1:184972662-185015946 (-)
FVB/NJ ENSMUSG00205031453
 protein coding gene Chr1:179397174-179440513 (-)
JF1/MsJ ENSUMUG00000005075
 protein coding gene Chr1:183982120-184025045 (-)
LP/J ENSMUSG00230020952
 protein coding gene Chr1:184534773-184577965 (-)
NOD/ShiLtJ ENSMUSG00190024163
 protein coding gene Chr1:180377162-180420354 (-)
NZO/HlLtJ ENSMUSG00225009894
 protein coding gene Chr1:188281272-188324632 (-)
PWK/PhJ ENSLUMG00010016547
 protein coding gene Chr1:179228190-179271475 (-)
SPRET/EiJ ENSMSPG00010028103
 protein coding gene Chr1:182720708-182763761 (-)
WSB/EiJ ENSIUOG00005011329
 protein coding gene Chr1:179567845-179611120 (-)



Homology
more
  • Human Ortholog
    MIA3, MIA SH3 domain ER export factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIA3, MIA SH3 domain ER export factor 3
  • Synonyms
    D320, ODCD2, TANGO, TANGO1, UNQ6077
  • Links
    NCBI Gene ID: 375056
    UniProt: Q5JRA6

  • Chr Location
    1q41; chr1:222618090-222668007 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous null for the large isoform display complete perinatal lethality with impaired collagen secretion, intracellular collagen aggregates, short limbed dwarfism, and arrest of chondrocyte maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    119
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      65
    • RefSeq
      16
    • UniProt
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056050 Ensembl Gene Model | MGI Sequence Detail 43213 C57BL/6J ±  kb
    transcript ENSMUST00000194543 Ensembl | MGI Sequence Detail 6330 Not Applicable  
    polypeptide ENSMUSP00000141268 Ensembl | MGI Sequence Detail 1930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138470, MGI:2138687, MGI:2686371
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:291566 Chang J, et al., Circadian control of the secretory pathway maintains collagen homeostasis. Nat Cell Biol. 2020 Jan;22(1):74-86
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory