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Mia3
Gene Detail
Symbol

Name
ID
Mia3
melanoma inhibitory activity 3
MGI:2443183
Synonyms
9130229H14Rik, A930039G15Rik, B230399H06Rik, LOC385255, Tango
Feature Type
protein coding gene
Genetic Map
Chromosome 1
Syntenic

Mapping data(2)
Sequence Map
Chr1:183326827-183369553 bp, - strand
From VEGA annotation of GRCm38

  42727 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:85165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MIA3
Gene Tree: Mia3

Human
homologs
MIA3, melanoma inhibitory activity family, member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 375056
neXtProt AC: NX_Q5JRA6

Human Synonyms: ARNT, D320, TANGO, TANGO1, UNQ6077

Human Chr (Location): 1q41; chr1:222618102-222668012 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
 
Mice homozygous null for the large isoform display complete perinatal lethality with impaired collagen secretion, intracellular collagen aggregates, short limbed dwarfism, and arrest of chondrocyte maturation.
 
Interactions
Mia3 interacts with 326 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process chondrocyte development, collagen fibril organization, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (118)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MIA3 ; Xenbase mia3    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000050580 (Evidence)
Ensembl Gene Model ENSMUSG00000056050 (Evidence)
Entrez Gene 338366 (Evidence)
DFCI TC1584627, TC1607274, TC1647272, TC1645043
DoTS DT.97340318, DT.94165971, DT.91433201, DT.111179357, DT.103577350, DT.55172275, DT.101712515
NIA Mouse Gene Index U062618
International Mouse Phenotyping Consortium Status Mia3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050580 VEGA Gene Model | MGI Sequence Detail 42727 C57BL/6J ±  kb
transcript OTTMUST00000131201 VEGA | MGI Sequence Detail 1904 Not Applicable 
polypeptide OTTMUSP00000070211 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000010395 melanoma inhibitory activity protein 3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:172737 Wilson DG, et al., Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J Cell Biol. 2011 May 30;193(5):935-51
All references(34)
Other
accession IDs
MGI:2138470, MGI:2138687, MGI:2686371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory