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Mia3
Gene Detail
 Symbol
Name
ID
Mia3
melanoma inhibitory activity 3
MGI:2443183
Synonyms 9130229H14Rik, A930039G15Rik, B230399H06Rik, LOC385255, Tango
Feature Type protein coding gene
Genetic Map
Chromosome 1
Syntenic

Mapping data(2)
Sequence Map
Chr1:183326725-183369529 bp, - strand
From Ensembl annotation of GRCm38

  42805 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:85165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mia3

Human
homologs
Human Homolog MIA3, melanoma inhibitory activity family, member 3
NCBI Gene ID 375056
neXtProt AC  NX_Q5JRA6
Human Synonyms  ARNT, D320, TANGO, TANGO1, UNQ6077
Human Chr (Location)  1q41; chr1:222618102-222668009 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
 
Mice homozygous null for the large isoform display complete perinatal lethality with impaired collagen secretion, intracellular collagen aggregates, short limbed dwarfism, and arrest of chondrocyte maturation.
 
Interactions
Mia3 interacts with 327 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chondrocyte development, collagen fibril organization, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (118)    Images (28)
Theiler Stages: 12, 14, 18, 19, 20, 22, 23
Assay TypeResults
RNA in situ 140
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000056050 (Evidence)
Entrez Gene338366 (Evidence)
DFCITC1584627, TC1607274, TC1645043, TC1647272
DoTSDT.101712515, DT.103577350, DT.111179357, DT.55172275, DT.91433201, DT.94165971, DT.97340318
NIA Mouse Gene IndexU062618
International Mouse Knockout Project StatusMia3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056050 Ensembl Gene Model | MGI Sequence Detail 42805 C57BL/6J ±  kb
transcript ENSMUST00000069922 Ensembl | MGI Sequence Detail 6417 Not Applicable 
polypeptide ENSMUSP00000064801 Ensembl | MGI Sequence Detail 1565 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000010395 melanoma inhibitory activity protein 3
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:172737 Wilson DG, et al., Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J Cell Biol. 2011 May 30;193(5):935-51
All references(35)
Other
accession IDs
MGI:2138470, MGI:2138687, MGI:2686371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory