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Uggt1 Gene Detail
Summary
  • Symbol
    Uggt1
  • Name
    UDP-glucose glycoprotein glucosyltransferase 1
  • Synonyms
    0910001L17Rik, A930007H10Rik, C820010P03Rik, Ugcgl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443162
    NCBI Gene: 320011
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36140028-36244320 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1025 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443162
protein coding gene Chr1:36140027-36244720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015918
protein coding gene Chr1:34642932-34751186 (-)
A/J MGP_AJ_G0015902
protein coding gene Chr1:33725094-33831333 (-)
AKR/J MGP_AKRJ_G0015857
protein coding gene Chr1:34209333-34316975 (-)
BALB/cJ MGP_BALBcJ_G0015856
protein coding gene Chr1:33421681-33526818 (-)
C3H/HeJ MGP_C3HHeJ_G0015689
protein coding gene Chr1:34394993-34500142 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016309
protein coding gene Chr1:36224100-36334266 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014031
protein coding gene Chr1:30788460-30895832 (-)
CAST/EiJ MGP_CASTEiJ_G0015270
protein coding gene Chr1:34276928-34385957 (-)
CBA/J MGP_CBAJ_G0015661
protein coding gene Chr1:37154259-37279047 (-)
DBA/2J MGP_DBA2J_G0015762
protein coding gene Chr1:33066092-33174652 (-)
FVB/NJ MGP_FVBNJ_G0015764
protein coding gene Chr1:32583640-32690833 (-)
LP/J MGP_LPJ_G0015832
protein coding gene Chr1:35015329-35126229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015784
protein coding gene Chr1:39411144-39520843 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016356
protein coding gene Chr1:34208504-34325508 (-)
PWK/PhJ MGP_PWKPhJ_G0015053
protein coding gene Chr1:32807436-32912858 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014835
protein coding gene Chr1:34186390-34293896 (-)
WSB/EiJ MGP_WSBEiJ_G0015332
protein coding gene Chr1:34182839-34287252 (-)



Homology
more
  • Human Ortholog
    UGGT1, UDP-glucose glycoprotein glucosyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UGGT1, UDP-glucose glycoprotein glucosyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUGT1, UGCGL1, UGT1
  • Links
    NCBI Gene ID: 56886
    neXtProt AC: NX_Q9NYU2
    UniProt: Q9NYU2

  • Chr Location
    2q14.3; chr2:128091180-128195677 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Heterozygous KO reduces susceptibility to and morbidity of RNA virus infection. Homozygous KO is embryonic lethal. The peptide is a folding sensor for glycoproteins in the ER.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 320011 NCBI Gene Model | MGI Sequence Detail 104293 C57BL/6J ±  kb
transcript NM_198899 RefSeq | MGI Sequence Detail 9045 C57BL/6  
polypeptide Q6P5E4 UniProt | EBI | MGI Sequence Detail 1551 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000017044 UDP-glucose:glycoprotein glucosyltransferase 1
  • EC
  • InterPro Domains
    IPR040497 Glucosyltransferase 24, catalytic domain
    IPR029044 Nucleotide-diphospho-sugar transferases
    IPR009448 UDP-glucose:Glycoprotein Glucosyltransferase
    IPR040525 UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4
    IPR040693 UGGT, thioredoxin-like domain 1
    IPR040694 UGGT, thioredoxin-like domain 2
    IPR040692 UGGT, thioredoxin-like domain 3
Molecular
Reagents
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  • All nucleic 251
    cDNA 251

    Microarray probesets 4
Other
Accession IDs
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MGI:1915668, MGI:2138118, MGI:2138223, MGI:2138245
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:244058 Huang PN, et al., UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication. PLoS Pathog. 2017 May;13(5):e1006375

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory