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Mib1 Gene Detail
Summary
  • Symbol
    Mib1
  • Name
    mindbomb E3 ubiquitin protein ligase 1
  • Synonyms
    E430019M12Rik, Mib, mind bomb-1, skeletrophin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443157
    NCBI Gene: 225164
  • Gene Overview
    MyGene.info: MIB1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:10725553-10818578 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 5.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443157
protein coding gene Chr18:10725548-10818704 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024151
protein coding gene Chr18:7665806-7766292 (+)
A/J MGP_AJ_G0024113
protein coding gene Chr18:7616193-7709168 (+)
AKR/J MGP_AKRJ_G0024080
protein coding gene Chr18:7818057-7910992 (+)
BALB/cJ MGP_BALBcJ_G0024112
protein coding gene Chr18:7599594-7694142 (+)
C3H/HeJ MGP_C3HHeJ_G0023879
protein coding gene Chr18:7707256-7804102 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024557
protein coding gene Chr18:8120230-8215707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021996
protein coding gene Chr18:7287440-7384373 (+)
CAST/EiJ MGP_CASTEiJ_G0023356
protein coding gene Chr18:7603798-7704786 (+)
CBA/J MGP_CBAJ_G0023851
protein coding gene Chr18:8181417-8276642 (+)
DBA/2J MGP_DBA2J_G0023980
protein coding gene Chr18:7483675-7576970 (+)
FVB/NJ MGP_FVBNJ_G0023945
protein coding gene Chr18:7430512-7524659 (+)
LP/J MGP_LPJ_G0024063
protein coding gene Chr18:7790599-7890252 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023974
protein coding gene Chr18:8423904-8522265 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024603
protein coding gene Chr18:7645986-7745945 (+)
PWK/PhJ MGP_PWKPhJ_G0023102
protein coding gene Chr18:7514997-7610588 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0023422
protein coding gene Chr18:7621260-7716962 (+)



Homology
more
  • Human Ortholog
    MIB1, mindbomb E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MIB1, mindbomb E3 ubiquitin protein ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIP1, DIP-1, LVNC7, MIB, ZZANK2, ZZZ6
  • Links
    NCBI Gene ID: 57534
    neXtProt AC: NX_Q86YT6
    UniProt: Q86YT6

  • Chr Location
    18q11.2; chr18:21740793-21870957 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10810
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MIB1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 3 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure of heart looping, impaired angiogenesis and arterial specification, premature neuronal precursor differentiation, posterior truncation, and abnormal somitogenesis with loss ofposterior markers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225164 NCBI Gene Model | MGI Sequence Detail 93026 C57BL/6J ±  kb
    transcript NM_144860 RefSeq | MGI Sequence Detail 10154 Not Specified  
    polypeptide Q80SY4 UniProt | EBI | MGI Sequence Detail 1006 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:264144 Eley L, et al., A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory