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Mib1 Gene Detail
Summary
  • Symbol
    Mib1
  • Name
    MIB E3 ubiquitin protein ligase 1
  • Synonyms
    E430019M12Rik, Mib, mindbomb, mind bomb-1, skeletrophin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443157
    NCBI Gene: 225164
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:10725548-10818704 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 5.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1905 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443157
 protein coding gene Chr18:10725523-10822969 (+)
129S1/SvImJ ENSMUSG00200024232
 protein coding gene Chr18:7668145-7762085 (+)
A/J ENSMUSG00195008573
 protein coding gene Chr18:7844465-7937624 (+)
AKR/J ENSMUSG00220018911
 protein coding gene Chr18:7835675-7928840 (+)
BALB/cJ ENSMUSG00180005330
 protein coding gene Chr18:8284725-8377918 (+)
C3H/HeJ ENSMUSG00175007284
 protein coding gene Chr18:7820076-7913260 (+)
C57BL/6NJ ENSMUSG00215012632
 protein coding gene Chr18:7562171-7655338 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021996
 protein coding gene Chr18:7287440-7384373 (+)
CAST/EiJ ENSTCUG00005016112
 protein coding gene Chr18:7654165-7748143 (+)
CBA/J ENSMUSG00210021436
 protein coding gene Chr18:7833000-7926187 (+)
DBA/2J ENSMUSG00185028939
 protein coding gene Chr18:7840464-7933624 (+)
FVB/NJ ENSMUSG00205022381
 protein coding gene Chr18:7619681-7712848 (+)
JF1/MsJ ENSUMUG00000024165
 protein coding gene Chr18:7901802-7995748 (+)
LP/J ENSMUSG00230028241
 protein coding gene Chr18:9912534-10017396 (+)
NOD/ShiLtJ ENSMUSG00190009207
 protein coding gene Chr18:7613194-7706352 (+)
NZO/HlLtJ ENSMUSG00225033867
 protein coding gene Chr18:9823895-9917056 (+)
PWK/PhJ ENSLUMG00010008700
 protein coding gene Chr18:8121765-8215724 (+)
SPRET/EiJ ENSMSPG00010011622
 protein coding gene Chr18:7755230-7850050 (+)
WSB/EiJ ENSIUOG00005026070
 protein coding gene Chr18:7693824-7786986 (+)



Homology
more
  • Human Ortholog
    MIB1, MIB E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIB1, MIB E3 ubiquitin protein ligase 1
  • Synonyms
    DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
  • Links
    NCBI Gene ID: 57534
    UniProt: Q86YT6

  • Chr Location
    18q11.2; chr18:21704916-21870953 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MIB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 4 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure of heart looping, impaired angiogenesis and arterial specification, premature neuronal precursor differentiation, posterior truncation, and abnormal somitogenesis with loss of posterior markers. Compound heterozygous global and conditional cardiac KO results in embryonic heart anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    73
  • cDNA Data
    23
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024294 Ensembl Gene Model | MGI Sequence Detail 93157 C57BL/6J ±  kb
    transcript ENSMUST00000052838 Ensembl | MGI Sequence Detail 10231 Not Applicable  
    polypeptide ENSMUSP00000054428 Ensembl | MGI Sequence Detail 1006 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 1
      Other 2
      Antibodies 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 22
      Gene Ontology 13
      Phenotypes 40
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:369665 Santos-Cantador J, et al., Patterning Defects in Mice with Defective Ventricular Wall Maturation and Cardiomyopathy. J Cardiovasc Dev Dis. 2025 Jun 12;12(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory