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Mib1
Gene Detail
 Symbol
Name
ID
Mib1
mindbomb homolog 1 (Drosophila)
MGI:2443157
Synonyms E430019M12Rik, Mib, mind bomb-1, skeletrophin
Feature Type protein coding gene
Genetic Map
Chromosome 18
5.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:10725548-10818704 bp, + strand
From VEGA annotation of GRCm38

  93157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mib1

Human
homologs
Human Homolog MIB1, mindbomb E3 ubiquitin protein ligase 1
NCBI Gene ID 57534
neXtProt AC  NX_Q86YT6
Human Synonyms  DIP1, DIP-1, LVNC7, MIB, ZZANK2, ZZZ6
Human Chr (Location)  18q11.2; chr18:21741329-21870957 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MIB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality during organogenesis, failure of heart looping, impaired angiogenesis and arterial specification, premature neuronal precursor differentiation, posterior truncation, and abnormal somitogenesis with loss of posterior markers.
 
Interactions
Mib1 interacts with 520 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process blood vessel development, heart development, ...
Component centrosome, cytoplasm, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (169)    Tissues (60)    Images (38)
Theiler Stages: 6, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 130
Northern blot 30
Western blot 3
RT-PCR 2
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(21) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000028579 (Evidence)
Ensembl Gene ModelENSMUSG00000024294 (Evidence)
Entrez Gene225164 (Evidence)
DFCITC1576637, TC1584694, TC1601824, TC1607184, TC1608987, TC1610778, TC1685363
DoTSDT.101736417, DT.101736418, DT.492473, DT.91335938, DT.91573580, DT.97369359
EC6.3.2.-
Consensus CDS ProjectCCDS29058.1
International Mouse Knockout Project StatusMib1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028579 VEGA Gene Model | MGI Sequence Detail 93157 C57BL/6J ±  kb
transcript OTTMUST00000070815 VEGA | MGI Sequence Detail 10231 Not Applicable 
polypeptide OTTMUSP00000036148 VEGA | MGI Sequence Detail 1006 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(268 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR010606 Mib-herc2
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000010396 E3 ubiquitin-protein ligase MIB1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:203926 Lee H, et al., The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways. Exp Neurol. 2013 Nov;249:83-94
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory