Nyap2 MGI Mouse Gene Detail - MGI:2443135 - neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

Sequence Map

Chr1:81054667-81319479 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443135	protein coding gene	Chr1:81054239-81345438 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016212	protein coding gene	Chr1:81933906-82220852 (+)
A/J	MGP_AJ_G0016195	protein coding gene	Chr1:79035725-79311114 (+)
AKR/J	MGP_AKRJ_G0016152	protein coding gene	Chr1:81187396-81462888 (+)
BALB/cJ	MGP_BALBcJ_G0016150	protein coding gene	Chr1:79102432-79383814 (+)
C3H/HeJ	MGP_C3HHeJ_G0015980	protein coding gene	Chr1:81550660-81840530 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016603	protein coding gene	Chr1:85108619-85400364 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014323	protein coding gene	Chr1:74322878-74588635 (+)
CAST/EiJ	MGP_CASTEiJ_G0015566	protein coding gene	Chr1:80937047-81251092 (+)
CBA/J	MGP_CBAJ_G0015954	protein coding gene	Chr1:87835300-88138457 (+)
DBA/2J	MGP_DBA2J_G0016055	protein coding gene	Chr1:78327601-78596077 (+)
FVB/NJ	MGP_FVBNJ_G0016058	protein coding gene	Chr1:77455638-77724111 (+)
LP/J	MGP_LPJ_G0016128	protein coding gene	Chr1:83068623-83357119 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016078	protein coding gene	Chr1:91151029-91489249 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016650	protein coding gene	Chr1:81349954-81628900 (+)
PWK/PhJ	MGP_PWKPhJ_G0015351	protein coding gene	Chr1:77756281-78034557 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015129	protein coding gene	Chr1:80603746-80883723 (+)
WSB/EiJ	MGP_WSBEiJ_G0015626	protein coding gene	Chr1:81109617-81403918 (+)

Human Ortholog

NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
Synonyms

KIAA1486
Links

HGNC:29291

NCBI Gene ID: 57624

neXtProt AC: NX_Q9P242

UniProt: Q9P242
Chr Location

2q36.3; chr2:225397939-225729887 (+) GRCh38

MGI Vertebrate Homology

Nyap2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NYAP2
Gene Tree

Nyap2

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Phenotype Summary

3 phenotypes from multigenic genotypes
8 phenotype references

Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons.

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Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

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			Length	Strain/Species	Flank
genomic	ENSMUSG00000054976	Ensembl Gene Model \| MGI Sequence Detail	264813	C57BL/6J	± kb
transcript	ENSMUST00000068275	Ensembl \| MGI Sequence Detail	4919	Not Applicable
polypeptide	ENSMUSP00000065468	Ensembl \| MGI Sequence Detail	737	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031028 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

(term hierarchy)
InterPro Domains

IPR026722 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2

IPR029353 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain

IPR039482 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal

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Summaries

All 26

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:322321 Catela C, et al., Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife. 2022 Mar 22;11:e70766

TSS for Nyap2:

(View these features in JBrowse)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23