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Nyap2 Gene Detail
Summary
  • Symbol
    Nyap2
  • Name
    neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
  • Synonyms
    9430031J16Rik, Jr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443135
    NCBI Gene: 241134
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:81076950-81341764 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 41.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1909 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443135
protein coding gene Chr1:81076558-81367705 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016212
protein coding gene Chr1:81933906-82220852 (+)
A/J MGP_AJ_G0016195
protein coding gene Chr1:79035725-79311114 (+)
AKR/J MGP_AKRJ_G0016152
protein coding gene Chr1:81187396-81462888 (+)
BALB/cJ MGP_BALBcJ_G0016150
protein coding gene Chr1:79102432-79383814 (+)
C3H/HeJ MGP_C3HHeJ_G0015980
protein coding gene Chr1:81550660-81840530 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016603
protein coding gene Chr1:85108619-85400364 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014323
protein coding gene Chr1:74322878-74588635 (+)
CAST/EiJ MGP_CASTEiJ_G0015566
protein coding gene Chr1:80937047-81251092 (+)
CBA/J MGP_CBAJ_G0015954
protein coding gene Chr1:87835300-88138457 (+)
DBA/2J MGP_DBA2J_G0016055
protein coding gene Chr1:78327601-78596077 (+)
FVB/NJ MGP_FVBNJ_G0016058
protein coding gene Chr1:77455638-77724111 (+)
LP/J MGP_LPJ_G0016128
protein coding gene Chr1:83068623-83357119 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016078
protein coding gene Chr1:91151029-91489249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016650
protein coding gene Chr1:81349954-81628900 (+)
PWK/PhJ MGP_PWKPhJ_G0015351
protein coding gene Chr1:77756281-78034557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015129
protein coding gene Chr1:80603746-80883723 (+)
WSB/EiJ MGP_WSBEiJ_G0015626
protein coding gene Chr1:81109617-81403918 (+)



Homology
more
  • Human Ortholog
    NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA1486
  • Links
    NCBI Gene ID: 57624
    neXtProt AC: NX_Q9P242
    UniProt: Q9P242

  • Chr Location
    2q36.3; chr2:225399710-225703653 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18239
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NYAP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Nyap2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054976 Ensembl Gene Model | MGI Sequence Detail 264815 C57BL/6J ±  kb
transcript ENSMUST00000068275 Ensembl | MGI Sequence Detail 4919 Not Applicable  
polypeptide ENSMUSP00000065468 Ensembl | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000031028 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
  • InterPro Domains
    IPR026722 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2
    IPR026723 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    IPR029353 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain
    IPR039482 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:239017 Steinmetz CC, et al., Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Rep. 2016 Sep 06;16(10):2711-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory