About   Help   FAQ
Nyap2 Gene Detail
Summary
  • Symbol
    Nyap2
  • Name
    neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
  • Synonyms
    9430031J16Rik, Jr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443135
    NCBI Gene: 241134
Location & Maps
more
  • Sequence Map
    Chr1:81076950-81341764 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      264815 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 41.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NYAP2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIAA1486
  • Links
    NCBI Gene ID: 57624
    neXtProt AC: NX_Q9P242

  • Chr Location
    2q36.3; chr2:225399710-225703653 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18239
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NYAP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Nyap2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026706 VEGA Gene Model | MGI Sequence Detail 264815 C57BL/6J ±  kb
transcript OTTMUST00000066075 VEGA | MGI Sequence Detail 4919 Not Applicable  
polypeptide OTTMUSP00000033041 VEGA | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1909 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR026722 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2
    IPR029353 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 1
References
more
  • Summaries
    All 16
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:72903 Boettger-Tong HL, et al., Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1129-35
  • Latest
    J:180006 Yokoyama K, et al., NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J. 2011 Nov 30;30(23):4739-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory