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Lrp12 Gene Detail
Summary
  • Symbol
    Lrp12
  • Name
    low density lipoprotein-related protein 12
  • Synonyms
    C820005L12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443132
    NCBI Gene: 239393
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:39870602-39943994 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    636 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443132
protein coding gene Chr15:39870589-39943994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021818
protein coding gene Chr15:38332282-38406977 (-)
A/J MGP_AJ_G0021778
protein coding gene Chr15:36828231-36907455 (-)
AKR/J MGP_AKRJ_G0021759
protein coding gene Chr15:37926373-38001122 (-)
BALB/cJ MGP_BALBcJ_G0021785
protein coding gene Chr15:36892291-36965522 (-)
C3H/HeJ MGP_C3HHeJ_G0021559
protein coding gene Chr15:37854181-37933609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022224
protein coding gene Chr15:39787909-39873714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019761
protein coding gene Chr15:34587021-34660402 (-)
CAST/EiJ MGP_CASTEiJ_G0021076
protein coding gene Chr15:38312089-38391381 (-)
CBA/J MGP_CBAJ_G0021528
protein coding gene Chr15:41213637-41287330 (-)
DBA/2J MGP_DBA2J_G0021652
protein coding gene Chr15:36678115-36754617 (-)
FVB/NJ MGP_FVBNJ_G0021630
protein coding gene Chr15:36057169-36131902 (-)
LP/J MGP_LPJ_G0021722
protein coding gene Chr15:38142798-38215963 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021654
protein coding gene Chr15:44200619-44276306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022247
protein coding gene Chr15:38102129-38176365 (-)
PWK/PhJ MGP_PWKPhJ_G0020821
protein coding gene Chr15:36734067-36806653 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020658
protein coding gene Chr15:37762391-37836247 (-)
WSB/EiJ MGP_WSBEiJ_G0021131
protein coding gene Chr15:38006942-38088875 (-)



Homology
more
  • Human Ortholog
    LRP12, LDL receptor related protein 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRP12, LDL receptor related protein 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MIG13A, ST7
  • Links
    NCBI Gene ID: 29967
    neXtProt AC: NX_Q9Y561
    UniProt: Q9Y561

  • Chr Location
    8q22.3; chr8:104489231-104589024 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8385
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRP12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 239393 NCBI Gene Model | MGI Sequence Detail 73393 C57BL/6J ±  kb
transcript NM_172814 RefSeq | MGI Sequence Detail 4315 C57BL/6  
polypeptide Q8BUJ9 UniProt | EBI | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009919 low-density lipoprotein receptor-related protein 12
  • InterPro Domains
    IPR000859 CUB domain
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR035914 Spermadhesin, CUB domain superfamily
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146083
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:230897 Grote A, et al., LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Neurobiol Dis. 2016 Feb;86:170-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory