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Cntln Gene Detail
Summary
  • Symbol
    Cntln
  • Name
    centlein, centrosomal protein
  • Synonyms
    B430108F07Rik, D530005L17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443104
    NCBI Gene: 338349
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:84802546-85050158 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 40.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1394 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443104
protein coding gene Chr4:84800024-85050160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028407
protein coding gene Chr4:84529537-84811064 (+)
A/J MGP_AJ_G0028368
protein coding gene Chr4:81610015-81857252 (+)
AKR/J MGP_AKRJ_G0028317
protein coding gene Chr4:83707973-83958091 (+)
BALB/cJ MGP_BALBcJ_G0028388
protein coding gene Chr4:81829858-82073172 (+)
C3H/HeJ MGP_C3HHeJ_G0028103
protein coding gene Chr4:84335132-84590486 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028827
protein coding gene Chr4:87834167-88109719 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026127
protein coding gene Chr4:77542277-77778518 (+)
CAST/EiJ MGP_CASTEiJ_G0027544
protein coding gene Chr4:82238680-82502320 (+)
CBA/J MGP_CBAJ_G0028072
protein coding gene Chr4:90522436-90795628 (+)
DBA/2J MGP_DBA2J_G0028221
protein coding gene Chr4:81386256-81648788 (+)
FVB/NJ MGP_FVBNJ_G0028187
protein coding gene Chr4:80381375-80629962 (+)
LP/J MGP_LPJ_G0028321
protein coding gene Chr4:84890494-85156209 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028216
protein coding gene Chr4:95628061-95906486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028864
protein coding gene Chr4:83771435-84030588 (+)
PWK/PhJ MGP_PWKPhJ_G0027267
protein coding gene Chr4:79736403-79989154 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027092
protein coding gene Chr4:81336539-81606556 (+)
WSB/EiJ MGP_WSBEiJ_G0027620
protein coding gene Chr4:83941717-84204592 (+)



Homology
more
  • Human Ortholog
    CNTLN, centlein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTLN, centlein
  • Synonyms
    bA340N12.1, C9orf101, C9orf39
  • Links
    NCBI Gene ID: 54875
    neXtProt AC: NX_Q9NXG0
    UniProt: Q9NXG0

  • Chr Location
    9p22.2; chr9:17134991-17510019 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele exhibit infertility due to impaired head to tail anchorage of spermatids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038070 Ensembl Gene Model | MGI Sequence Detail 247613 C57BL/6J ±  kb
    transcript ENSMUST00000047023 Ensembl | MGI Sequence Detail 5528 Not Applicable  
    polypeptide ENSMUSP00000044138 Ensembl | MGI Sequence Detail 1397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925769, MGI:2140280
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:324173 Zhang Y, et al., The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus. Nat Commun. 2021 Aug 13;12(1):4926

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/26/2022
    MGI 6.22
    The Jackson Laboratory