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Cpeb3 Gene Detail
Summary
  • Symbol
    Cpeb3
  • Name
    cytoplasmic polyadenylation element binding protein 3
  • Synonyms
    4831444O18Rik, mKIAA0940
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443075
    NCBI Gene: 208922
Location & Maps
more
  • Sequence Map
    Chr19:37021291-37208601 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      187311 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CPEB3, cytoplasmic polyadenylation element binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPEB3, cytoplasmic polyadenylation element binding protein 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 22849
    neXtProt AC: NX_Q8NE35

  • Chr Location
    10q23.32; chr10:92048638-92291118 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40992
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CPEB3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced female fertility, increased anxiety-related response, enhanced contextual conditioning behavior, abnormal spatial reference memory, hypoactivity and abnormal hippocampus pyramidal cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033003 VEGA Gene Model | MGI Sequence Detail 187311 C57BL/6J ±  kb
transcript OTTMUST00000082317 VEGA | MGI Sequence Detail 5899 Not Applicable  
polypeptide OTTMUSP00000044106 VEGA | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    706 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 7
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:223363 Fioriti L, et al., The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron. 2015 Jun 17;86(6):1433-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory