Ppwd1 MGI Mouse Gene Detail - MGI:2443069 - peptidylprolyl isomerase domain and WD repeat containing 1

Symbol

Ppwd1
Name

peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms

4632422M10Rik, A330090G21Rik

Feature Type

protein coding gene
IDs

MGI:2443069
NCBI Gene: 238831
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:104341632-104365351 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 56.39 cM
Mapping Data

1 experiment

SNPs within 2kb

1328 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443069	protein coding gene	Chr13:104340102-104365378 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020906	protein coding gene	Chr13:106295799-106323644 (-)
A/J	MGP_AJ_G0020857	protein coding gene	Chr13:102160266-102183562 (-)
AKR/J	MGP_AKRJ_G0020832	protein coding gene	Chr13:105270592-105295755 (-)
BALB/cJ	MGP_BALBcJ_G0020857	protein coding gene	Chr13:102869687-102893815 (-)
C3H/HeJ	MGP_C3HHeJ_G0020646	protein coding gene	Chr13:105006148-105029725 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021291	protein coding gene	Chr13:109491067-109516499 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018861	protein coding gene	Chr13:97779559-97803126 (-)
CAST/EiJ	MGP_CASTEiJ_G0020164	protein coding gene	Chr13:104445255-104500248 (-)
CBA/J	MGP_CBAJ_G0020608	protein coding gene	Chr13:113742460-113768100 (-)
DBA/2J	MGP_DBA2J_G0020732	protein coding gene	Chr13:101925849-101949615 (-)
FVB/NJ	MGP_FVBNJ_G0020714	protein coding gene	Chr13:100623615-100647027 (-)
LP/J	MGP_LPJ_G0020806	protein coding gene	Chr13:106321442-106346729 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020742	protein coding gene	Chr13:113932559-113960897 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021330	protein coding gene	Chr13:104744399-104768545 (-)
PWK/PhJ	MGP_PWKPhJ_G0019917	protein coding gene	Chr13:100633812-100685806 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019739	protein coding gene	Chr13:100914557-100967112 (-)
WSB/EiJ	MGP_WSBEiJ_G0020223	protein coding gene	Chr13:105213075-105237854 (-)

Human Ortholog

PPWD1, peptidylprolyl isomerase domain and WD repeat containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPWD1, peptidylprolyl isomerase domain and WD repeat containing 1
Links

HGNC:28954

NCBI Gene ID: 23398

UniProt: Q96BP3
Chr Location

5q12.3; chr5:65563236-65587549 (+) GRCh38

MGI Vertebrate Homology

Ppwd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPWD1
Gene Tree

Ppwd1

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppwd1

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All Sequences

50
RefSeq

15
UniProt

2
CCDS

CCDS26748.1

Ensembl

ENSMUSG00000021713 (Evidence)
NCBI Gene

238831

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021713	Ensembl Gene Model \| MGI Sequence Detail	23720	C57BL/6J	± kb
transcript	ENSMUST00000022226	Ensembl \| MGI Sequence Detail	2342	Not Applicable
polypeptide	ENSMUSP00000022226	Ensembl \| MGI Sequence Detail	646	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013163 peptidylprolyl isomerase domain and WD repeat-containing protein 1

(term hierarchy)
EC

5.2.1.8
InterPro Domains

IPR029000 Cyclophilin-like domain superfamily

IPR044666 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like

IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q8CEC6 1 site

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All nucleic 21

Genomic 2

cDNA 19

Microarray probesets 2

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MGI:2444794

Summaries

All 32

Gene Ontology 10

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Ppwd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123920	Chr13:104365341-104365357 (-)	2 bp
Tssr123919	Chr13:104365310-104365336 (-)	28 bp
Tssr123918	Chr13:104341849-104341853 (-)	23,500 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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