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Agps Gene Detail
Summary
  • Symbol
    Agps
  • Name
    alkylglycerone phosphate synthase
  • Synonyms
    9930035G10Rik, ADAPS, bs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443065
    NCBI Gene: 228061
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:75832177-75931350 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443065
protein coding gene Chr2:75832177-75931350 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025859
protein coding gene Chr2:76214134-76318597 (+)
A/J MGP_AJ_G0025836
protein coding gene Chr2:73226688-73325748 (+)
AKR/J MGP_AKRJ_G0025804
protein coding gene Chr2:75203246-75304269 (+)
BALB/cJ MGP_BALBcJ_G0025830
protein coding gene Chr2:73414076-73513137 (+)
C3H/HeJ MGP_C3HHeJ_G0025590
protein coding gene Chr2:75408572-75517402 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026277
protein coding gene Chr2:78480675-78581451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023680
protein coding gene Chr2:70644606-70744684 (+)
CAST/EiJ MGP_CASTEiJ_G0025054
protein coding gene Chr2:75731663-75838079 (+)
CBA/J MGP_CBAJ_G0025571
protein coding gene Chr2:81359029-81468761 (+)
DBA/2J MGP_DBA2J_G0025702
protein coding gene Chr2:72822469-72921421 (+)
FVB/NJ MGP_FVBNJ_G0025664
protein coding gene Chr2:72208997-72307163 (+)
LP/J MGP_LPJ_G0025790
protein coding gene Chr2:76063972-76174265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025695
protein coding gene Chr2:83231120-83342572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026334
protein coding gene Chr2:75340585-75443078 (+)
PWK/PhJ MGP_PWKPhJ_G0024795
protein coding gene Chr2:72781572-72883018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024603
protein coding gene Chr2:75566997-75671447 (+)
WSB/EiJ MGP_WSBEiJ_G0025122
protein coding gene Chr2:75787586-75893234 (+)



Homology
more
  • Human Ortholog
    AGPS, alkylglycerone phosphate synthase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGPS, alkylglycerone phosphate synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY, RCDP3
  • Links
    NCBI Gene ID: 8540
    neXtProt AC: NX_O00116
    UniProt: O00116

  • Chr Location
    2q31.2; chr2:177392743-177543836 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2716
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGPS
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Agps mouse models; 1 with human AGPS associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit male infertility, azoospermia, microphthalmia, and cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228061 NCBI Gene Model | MGI Sequence Detail 99174 C57BL/6J ±  kb
    transcript NM_172666 RefSeq | MGI Sequence Detail 7375 C57BL/6  
    polypeptide Q8C0I1 UniProt | EBI | MGI Sequence Detail 645 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • EC
    • InterPro Domains
      IPR025650 Alkyldihydroxyacetonephosphate synthase
      IPR016166 FAD-binding domain, PCMH-type
      IPR036318 FAD-binding, type PCMH-like superfamily
      IPR016167 FAD-binding, type PCMH, subdomain 1
      IPR004113 FAD-linked oxidase, C-terminal
      IPR016164 FAD-linked oxidase-like, C-terminal
      IPR006094 FAD linked oxidase, N-terminal
      IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139316, MGI:3777321
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory