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Agps Gene Detail
Summary
  • Symbol
    Agps
  • Name
    alkylglycerone phosphate synthase
  • Synonyms
    9930035G10Rik, ADAPS, bs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443065
    NCBI Gene: 228061
Location & Maps
more
  • Sequence Map
    Chr2:75832177-75931350 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      99174 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AGPS, alkylglycerone phosphate synthase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGPS, alkylglycerone phosphate synthase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY
  • Links
    NCBI Gene ID: 8540
    neXtProt AC: NX_O00116

  • Chr Location
    2q31.2; chr2:177392743-177543836 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2716
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AGPS
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Agps mouse models; 1 with human AGPS associations

Human Disease Mouse Models
       Rhizomelic Chondrodysplasia Punctata, Type 3; RCDP3   OMIM: 600121 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    119
  • Chemically induced (other)
    1
  • Gene trapped
    114
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Agps
  • Incidental Mutations
Mice homozygous for a spontaneous allele exhibit male infertility, azoospermia, microphthalmia, and cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013293 VEGA Gene Model | MGI Sequence Detail 99174 C57BL/6J ±  kb
transcript OTTMUST00000032119 VEGA | MGI Sequence Detail 7359 Not Applicable  
polypeptide OTTMUSP00000014280 VEGA | MGI Sequence Detail 671 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    516 from dbSNP Build 137
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000003842 alkyldihydroxyacetonephosphate synthase, peroxisomal
  • EC
  • InterPro Domains
    IPR025650 Alkyldihydroxyacetonephosphate synthase
    IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    IPR016166 FAD-binding, type 2
    IPR016167 FAD-binding, type 2, subdomain 1
    IPR004113 FAD-linked oxidase, C-terminal
    IPR016164 FAD-linked oxidase-like, C-terminal
    IPR006094 FAD linked oxidase, N-terminal
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 6
Other
Accession IDs
less
MGI:2139316, MGI:3777321
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory