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Mylk3
Gene Detail
 Symbol
Name
ID
Mylk3
myosin light chain kinase 3
MGI:2443063
Synonyms D830007F02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:85324303-85386345 bp, - strand
From VEGA annotation of GRCm38

  62043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mylk3

Human
homologs
Human Homolog MYLK3, myosin light chain kinase 3
NCBI Gene ID 91807
neXtProt AC  NX_Q32MK0
Human Synonyms  caMLCK, MLCK, MLCK2
Human Chr (Location)  16q11.2; chr16:46702282-46763287 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit cardiac hypertrophy, reduced cardiac function and increased response of heart to induced stress.
 
Phenotype Images(1)
Interactions
Mylk3 interacts with 167 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cardiac myofibril assembly, cellular response to interleukin-1, ...
Component actin cytoskeleton, cytoplasm, ...
Function ATP binding, calmodulin-dependent protein kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (68)    Tissues (4)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 68
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000031870 (Evidence)
Ensembl Gene ModelENSMUSG00000031698 (Evidence)
Entrez Gene213435 (Evidence)
UniGene32804
DFCITC1584596, TC1592751, TC1626273, TC1690351
DoTSDT.101722944, DT.91319108, DT.99863365
NIA Mouse Gene IndexU030054
EC2.7.11.18
Consensus CDS ProjectCCDS40422.1
International Mouse Knockout Project StatusMylk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031870 VEGA Gene Model | MGI Sequence Detail 62043 C57BL/6J ±  kb
transcript OTTMUST00000079019 VEGA | MGI Sequence Detail 3696 Not Applicable 
polypeptide OTTMUSP00000042108 VEGA | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(892 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000029126 myosin light chain kinase 3
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:204224 Chang AN, et al., The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. PLoS One. 2013;8(6):e66720
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory