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Dnajc27 Gene Detail
Summary
  • Symbol
    Dnajc27
  • Name
    DnaJ heat shock protein family (Hsp40) member C27
  • Synonyms
    C330021A05Rik, Rabj, Rbj
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443036
    NCBI Gene: 217378
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4082583-4110606 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 1.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443036
protein coding gene Chr12:4082569-4124140 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019563
protein coding gene Chr12:941021-968999 (+)
A/J MGP_AJ_G0019530
protein coding gene Chr12:961525-993648 (+)
AKR/J MGP_AKRJ_G0019500
protein coding gene Chr12:1114669-1144723 (+)
BALB/cJ MGP_BALBcJ_G0019505
protein coding gene Chr12:989160-1017394 (+)
C3H/HeJ MGP_C3HHeJ_G0019311
protein coding gene Chr12:892327-924944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019954
protein coding gene Chr12:960282-990311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017579
protein coding gene Chr12:869892-902299 (+)
CAST/EiJ MGP_CASTEiJ_G0018866
protein coding gene Chr12:966964-998633 (+)
CBA/J MGP_CBAJ_G0019282
protein coding gene Chr12:1211264-1242233 (+)
DBA/2J MGP_DBA2J_G0019395
protein coding gene Chr12:903320-931927 (+)
FVB/NJ MGP_FVBNJ_G0019385
protein coding gene Chr12:927997-957154 (+)
LP/J MGP_LPJ_G0019466
protein coding gene Chr12:959969-992082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019419
protein coding gene Chr12:1018278-1048651 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019993
protein coding gene Chr12:896509-926532 (+)
PWK/PhJ MGP_PWKPhJ_G0018632
protein coding gene Chr12:925581-954301 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018423
protein coding gene Chr12:966484-996547 (+)
WSB/EiJ MGP_WSBEiJ_G0018918
protein coding gene Chr12:924808-952817 (+)



Homology
more
  • Human Ortholog
    DNAJC27, DnaJ heat shock protein family (Hsp40) member C27
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAJC27, DnaJ heat shock protein family (Hsp40) member C27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RabJS, RBJ
  • Links
    NCBI Gene ID: 51277
    neXtProt AC: NX_Q9NZQ0
    UniProt: Q9NZQ0

  • Chr Location
    2p23.3; chr2:24943636-24972094 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased incidence, multiplicity and tumor burden in an AOM/DSS-induced colonic carcinogenesis model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020657 Ensembl Gene Model | MGI Sequence Detail 28024 C57BL/6J ±  kb
transcript ENSMUST00000020986 Ensembl | MGI Sequence Detail 4698 Not Applicable  
polypeptide ENSMUSP00000020986 Ensembl | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144867
References
more
  • Summaries
    All 31
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:210622 Chen T, et al., Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. Cancer Cell. 2014 May 12;25(5):682-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory